[cid:image005.jpg@01D92A50.1D4B3A80] BME MONDAY ROUNDTABLE JANUARY 16, 2023 HEADS NOTE Hello everyone! Here's the official roundtable for the week. We just sent an update from Dr. Luis Solorio, Chair of the BME DEI committee about events happening across Purdue this week. We also have a prospective BME faculty member seminar this Weds at 9:30! Be sure to attend and hear from Dr. Jacob Rosenstein about integrated semiconductors for life sciences. Have a great week! UPCOMING IMPORTANT DATES Week of January 16 Tues. Jan. 17 - Fri., Jan. 20: ACE Campus Food Pantry food drive. Need to clean out your home pantry? The ACE Campus Food Pantry will be having a food drive this week. See the article below for dates and locations of collection sites. ACE is a student-run food pantry that provides fresh produce, hygiene products and a large selection of dried foods and snacks for Purdue community members so they have what they need to thrive while at Purdue. All you need to be a client is a Purdue ID. Help support your fellow Boilermakers! Wed., Jan. 18: BME PhD Preliminary Exam announcement for Alexa Petrucciani (E. Pienaar, advisor), 8:00 a.m., MJIS 2001 and via Zoom. Title of presentation: Agent-Based Modeling of Cell Culture Granuloma Models: Separating the Impact of Dimension, Collagen, and Non-Immune Cells Wed., Jan. 18: Prospective BME Faculty Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Jacob Rosenstein, Associate Professor of Engineering, Brown University will present "Integrated Semiconductors for the Life Sciences." (Note: Students registered for credit for the seminar are expected to attend in-person.) Thurs., Jan. 19: Seminars in Hearing Research, 10:30 - 11:20 a.m., LYLE 1150 and via Zoom. Hari Bharadwaj, Assistant Professor, Department of Communication Sciences & Disorders at the University of Pittsburgh will present "Physiological Characterization of Persistent Tinnitus." Zoom link: https://purdue.-edu.zoom.us/j/4326340458 (Meeting ID: 432 634 0458). Thurs., Jan. 19: College of Veterinary Medicine Special Seminar, Shawn Burgess, PhD, Senior Investigator and Head of Developmental Genomics Section will present "Gene Regulatory Networks and Metabolic Factors Driving Regeneration in Zebrafish" at 12:30 p.m. in Lynn Hall 1136. Upcoming important deadlines and info. Tues., Jan. 24: Special Guest Lecture: Former U.S. Surgeon General Dr. Jerome Adams<https://www.purdue.edu/provost/health/adams.html> will be guest lecturing in the course BME395/HONR399: Engineering Health Equity from 3:00-4:00 p.m. in RHPH 172. As this is an incredible opportunity to hear from a world-renowned expert in public health and health policy. We will be opening up the class to other students who may be interested in attending his lecture, "Perspectives on Health Equity from the 20th Surgeon General of the United States." Please feel free to attend; seating will be first come, first served. Dr. Adams is a Distinguished Professor of Practice in Pharmacy and is the Presidential Fellow and Executive Director of Purdue's Health Equity Initiatives. During his time leading the Indiana State Department of Health before becoming US Surgeon General Dr. Adams led initiatives for legalizing syringe services programs, reducing infant mortality, and pandemic/outbreak responses. Wed., Jan. 25: Prospective BME Faculty Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Sunghee (Estelle) Park, PhD Candidate and CEMB Fellow, Department of Bioengineering at the University of Pennsylvania will present "Engineering Stem Cells and Organoids on a Chip." (Note: Students registered for credit for the seminar are expected to attend in-person.) Wed., Jan. 25: BME PhD Preliminary Exam announcement for Luke Brennan (J. Linnes and N. Rodriguez, co-advisors), 11:00 a.m., MJIS 2001 and via Zoom. Title of presentation: HPV Rapid Diagnostic Test Development Through Human-Centered Design. Wed., Feb. 1: Prospective BME Faculty Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Wei Ouyang, Postdoctoral Fellow, Bioelectronics, Northwestern University will present "Integrated Bioelectronic Systems for Biomedical Research and Healthcare: Materials, Electronics, and Computing." (Note: Students registered for credit for the seminar are expected to attend in-person.) Fri., Feb. 3: The Great Lakes NSF I-Corps Hub and Purdue I-Corps are offering various workshops in Spring 2023 that can significantly increase the chances of securing federal proof of concept & commercialization grants like SBIR/STTR, PFI-TT that range from $500k to $1.6 million. The historical success rate for Purdue Faculty, who complete the NSF I-corps workshops, and apply for these competitive NSF research commercialization grants is over 90%. Please find details of the workshops below. STEM Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-stem-jumpstart/>: Feb 3 - March 24 Medical Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-medical-jumpstart-i-corps-course/>: Feb 3 - March 24 Purdue I-Corps Discovery, Discovery+<https://www.greatlakesicorps.org/event/winter-2023-purdue-i-corps-discovery/>: Feb 17-March 24; March 31-April 7 Gain new insights about your research, explore the commercial potential, learn about NSF funding opportunities, and increase your industry and professional network. Learn from our NSF-certified instructors, experienced entrepreneurs, and mentors. If a student/Post-doc in your lab is interested in this opportunity and would like to learn more, please reach out to Geetali Pradhan at gpradhan@purdue.edu<mailto:gpradhan@purdue.edu> Wed., Feb. 8: Prospective BME Faculty Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University will present "Traditional and computational development of fluorescence imaging tools for neuroscience." (Note: Students registered for credit for the seminar are expected to attend in-person.) Fri., Feb. 17: Clinical and Translational Sciences (CTSI) Winter Retreat, 9:30 a.m. - 3:00 p.m., Purdue University West Lafayette campus, Hall for Discovery Learning and Research, Room 131. Agenda includes: * Introduction from Indiana CTSI * Keynote Speakers on women's health research * Janine Austin Clayton, MD, FARVO, NIH Associate Director for Research on Women's Health and Director, NIH Office of Research on Women's Health * Lindsay Weaver, MD, FACEP, Chief Medical Officer, Indiana Department of Health * Discussion panels including topics on: o Maternal and child health o Obesity and chronic diseases o Neurodegenerative disorder and aging o Women's health in rural areas Full agenda and registration links at https://engineering.purdue.edu/BME/CTSI/Winter-Retreat . This event is sponsored by the Purdue University Women's Global Health Institute and the Indiana CTSI. Registration closes February 14. PURDUE ADVERSE WINTER WEATHER POLICY If adverse weather conditions necessitate that a wind chill, snow or ice emergency be declared for the West Lafayette campus, special procedures pertaining to classes, operations, parking, pay and/or attendance will become effective. Jay Wasson, vice president for physical facilities and chief public safety officer, describes procedures for adverse winter weather in this memo<https://www.purdue.edu/ehps/emergency-preparedness/docs/adverse-winter-weather.pdf>. Committee Updates Graduate Office Update Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. * Research-Credit Expectations Discussions and Documentation. A BME-developed form is attached to facilitate the documentation of research-credit expectations for any students taking 59800, 59900, 69800 or 69900, which is required by the Grad School (and is best practice, and as such endorsed by the BME Graduate Committee!). * This form is intended to be student-initiated since these are the student's research credits, but then must be discussed with the faculty mentor and refined and then signed by both. * Faculty must then document completion for each student they are mentoring (see attached instructions from Registrar's office -simply CHECK THE BOX in myPurdue). This is required, so thank you for checking the box to document your efforts! * DUE DATE: Fri Jan 20th. Note: Any form of documentation will do - our form is just a helpful template to hopefully make it easier for everyone. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Jan 26 Agendas for all invited students due from faculty to Tammy and sent to student. Feb 2-4 Weldon School Visitation Days (Hybrid) Feb 8 Last chance for Research Areas / Faculty to remove students from fellowship consideration Feb 10 Fellowship offers announced and complete rankings list made available to BME faculty; BME Graduate Office will notify students by email (offer letters distributed as soon as signed by BME Head and COE Dean) Mar 10 DUE: All Master's students to be decisioned as either admit, deny or hold Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline BME Faculty Search Update The Faculty Search Committee has invited four faculty candidates to campus for interviews. If you are interested in meeting with any of the candidates, please contact Jo Gelfand (jo@purdue.edu<mailto:jo@purdue.edu>). All candidates will give a research seminar in MJIS 1001 at 9:30 a.m. on the Wednesday of their visit. Jan. 18-19 - Jacob Rosenstein, Associate Professor of Engineering, Brown University Jan. 25-26 - Sunghee Estelle Park, PhD Candidate and CEMB Fellow, Bioengineering, Univ. of PA Feb. 1-2 - Wei Ouyang, Postdoctoral Fellow, Bioelectronics, Northwestern Univ. Feb. 8-9 - Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke Univ. Diversity, Equity and Inclusion Committee Welcome back! This week is Diversity Awareness Week at Purdue via Colleges of Ag and Health & Human Sciences. All of the events are open to the public, and include a virtual option. The events will be held in the Deans Auditorium in Pfendler Hall from 12:00-1:30 PM unless indicated otherwise. Contact Dr. Linnette White, lcwhite@purdue.edu<mailto:lcwhite@purdue.edu>, if you require accommodations for any of the events. Register to the events using the link below. REGISTER FOR ALL EVENTS<https://purdue.ag/MLKweek-rsvp> Additionally, there will be a FREE Martin Luther King, Jr. commemorative event with Morgan State University choir on Tuesday Jan 17th at 7:00 PM at Loeb Playhouse. RSVP TODAY!<https://maillinks.purdue.edu/t/44228884/1572750284/94476557/2/1003565/?x=07c161d2> [cid:image006.png@01D92A50.1D4B3A80] Resources and further information ACE Campus Food Pantry food drive, Tues. Jan. 17 - Fri., Jan. 20: In addition to the traditional Martin Luther King Jr. Day of Service, the ACE Campus Food Pantry is coordinating a food drive with the support of the Roger C. Stewart Center for Leadership & Professional Development; Office of Diversity, Inclusion and Belonging; Intercollegiate Athletics; Campus Support Staff Advisory Committee (CSSAC); Management and Professional Staff Advisory Committee (MaPSAC); Purdue Student Government; Purdue Graduate Student Government; Fraternity, Sorority and Cooperative Life; and University Residences. The food drive<https://www.purdue.edu/vpsl/leadership/Events/ACE-Food-Drive.html> will take place Jan. 17-20. The ACE Pantry van (recognizable by purple polka dots around the vehicle) will be parked outside of locations during the times listed below, and items may be donated by walking or driving up to the van. * Jan. 17: 1-2 p.m. behind Hovde Hall; 2-4 p.m. at the Class of 1950 Lecture Hall. * Jan. 18: 10 a.m. to 1 p.m. at Mackey Arena; 2-3 p.m. at the Purdue Graduate Student Center. * Jan. 19: 1-3 p.m. at Krach Leadership Center; 3-5 p.m. at Lilly Hall of Life Sciences. * Jan. 20: 10 a.m. to 2 p.m. at participating Fraternity, Sorority and Cooperative Life (FSCL) locations. ACE is a student-run food pantry that provides fresh produce, hygiene products and a large selection of dried foods and snacks for Purdue community members so they have what they need to thrive while at Purdue. All you need to be a client is a Purdue ID. For more information on ACE, visit purdue.edu/leadership<https://www.purdue.edu/vpsl/leadership/>. Prospective BME Faculty Seminar, Wed., Jan. 18, 9:30 a.m. in MJIS 1001 and via Zoom. Jacob Rosenstein, Associate Professor of Engineering, Brown University will present "Integrated Semiconductors for the Life Sciences." Abstract: One of the most significant trends in modern science is the growth of information technology and microelectronics into life science applications. In this talk I will review my lab's research on the conceptual and physical integration of electrical, biological, and chemical systems. I will discuss the latest progress on a new class of semiconductor sensors which use more than 100,000 active addressable microelectrodes to create non-destructive all-electrical "images" of cells, particles, biofilms, and other materials near the surface of the sensor. I will also review some of our recent collaborative work on digital information storage using mixtures of natural metabolites and synthetic small-molecule libraries. I hope that by re-imagining semiconductor circuits as bioelectronic interfaces, and considering chemical systems as abstract stores of information, we can uncover new ways to interact with the natural world. Bio: Jacob K. Rosenstein is an Associate Professor in the School of Engineering at Brown University, in Providence, Rhode Island. He received a Ph.D. in electrical engineering from Columbia University, and previously worked in the wireless division at Analog Devices and MediaTek. His research focuses on electronic interfaces with chemical and biological systems, which has included integrated circuits for DNA sequencing, molecular information systems, machine olfaction, and smart cell culture platforms. ~BME Host: Hugh Lee~ Zoom link: https://purdue-edu.zoom.us/j/94936026728?pwd=K3ZHcTN5Q2JrSGk3YTJwZVVxUHoxdz0... BME PhD Preliminary Exam announcement for Alexa Petrucciani (E. Pienaar, advisor), Wed., Jan. 18, 8:00 a.m., MJIS 2001 and via Zoom. Everyone is invited to attend the public presentation beginning at 8:00am. Title of presentation: Agent-Based Modeling of Cell Culture Granuloma Models: Separating the Impact of Dimension, Collagen, and Non-Immune Cells Thesis Committee: Dr. Elsje Pienaar - Major Professor; Dr. Tamara Kinzer-Ursem, Dr. Nan Kong, Dr. Nelita du Plessis, Dr. Bradley Allen Abstract: Tuberculosis (TB) remains a global public health crisis, causing over 10 million new infections and 1.6 million deaths in 2021 alone. TB is caused by Mycobacterium tuberculosis (Mtb), which is spread via respiratory droplets. After inhalation, the bacteria initiate heterogeneous pathology in the lungs, including granulomas and cavities. Granulomas are organized structures of immune cells, traditionally though to contain the bacteria, and cavities are pathological spaces are caused by the destruction of extracellular matrix (ECM), which can worsen disease outcomes and cause long-lasting pulmonary impairment. In vitro methods are commonly used to study host-pathogen interactions in Mtb infection, and recent developments have led to more advanced models that represent the TB granuloma environment more closely than the traditional cell culture counterparts. These advances include the development of 3D models, the inclusion of physiological ECM components like collagen, and the co-culturing of immune cells with neighboring nonimmune cells. Increasing complexity has been accomplished in a piece-wise manner - minimally necessary components are included to minimize cost while maintaining throughput and tractability. This creates a need for tools to analyze these systems and, more importantly, integrate the independent data created. We propose using agent-based modeling of in vitro Mtb infection models to separate out the contributions of dimension, collagen, and neighboring cells to clinically relevant outputs: bacterial load and ECM destruction. The model can provide insights into the role of granuloma structure, elucidate the emergence of cavities, predict drug targets, and generate and test hypotheses in tandem with in vitro models. Zoom link: https://purdue-edu.zoom.us/j/9607220370 College of Veterinary Medicine Special Seminar, Shawn Burgess, PhD, Senior Investigator and Head of Developmental Genomics Section will present "Gene Regulatory Networks and Metabolic Factors Driving Regeneration in Zebrafish" on Thurs., Jan. 19 at 12:30 p.m. in Lynn Hall 1136. Abstract: Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. This provides an opportunity to study mechanisms of tissue regeneration that have fallen dormant in mammals, including humans. We use two models of regeneration in zebrafish: adult inner ear regeneration and larval tailfin regeneration to study the various forces involved in wound healing and regeneration. Using adult zebrafish inner ears as a model for sensorineural regeneration, we performed a targeted ablation of the mechanosensory receptors in the saccule and utricle and characterized the single-cell epigenome and transcriptome at consecutive time-points following hair cell ablation. We show that precise timing of sox2 expression is critical to proper hair cell regeneration. We utilized a larval tail regeneration assay in the zebrafish Danio rerio. Regeneration of the embryonic zebrafish tail requires development of a blastema, a mass of dedifferentiated cells capable of replacing lost tissue, a crucial step in all known examples of appendage regeneration. We showed that tail amputation triggers an obligate metabolic shift to promote glucose metabolism during early regeneration similar to the Warburg effect observed in tumor forming cells. Inhibition of glucose metabolism completely blocked the f in from regenerating after amputation due to the failure to form a functional blastema. We further showed that this metabolic pathway was necessary to shunt metabolites to the hexosamine biosynthetic pathway. Prospective BME Faculty Seminar, Wed., Jan. 25, 9:30 a.m. in MJIS 1001 and via Zoom. Sunghee (Estelle) Park, PhD Candidate and CEMB Fellow, Department of Bioengineering at the University of Pennsylvania will present "Engineering Stem Cells and Organoids on a Chip." Abstract: Organ development is a complex process that involves highly coordinated, dynamic changes in the structural organization and mechanical environment of developing tissues. Recent advances in our understanding of stem cells have led to the development of human adult stem cell or pluripotent stem cell-derived organoids that follow the developmental trajectories of living human organs in vitro and create multicellular tissue constructs that recapitulate the key structural and functional aspects of human organs with greater biological and cellular complexity. In parallel, organ-on-a-chip technology allows us to engineer human organ-like tissue constructs by enabling precise control over their culture conditions and microenvironment. Inspired by the potential of combining these two approaches, we are interested in creating microfabricated devices and developing stem cell-based tissue engineering approaches to investigate the biochemical and biomechanical cues that are responsible for guiding organoid growth and maturation. I will discuss how we synergistically combine organoids and organ-on-a-chip technology, so called organoids-on-a-chip, to create in vitro replicas of living human organs with unprecedented levels of maturity and complexity. Using these platforms, I will also describe efforts to uncover the critical roles of different biophysical mechanisms in fetal lung development. Bio: Estelle Park is a PhD candidate in Bioengineering at the University of Pennsylvania. Her research focuses on using engineered tissues and organoid models to understand how biomechanical and biochemical cues direct stem cell differentiation, maturation, and function during development and disease progression, with a particular emphasis on the lung and intestine. Her research is best known for growing stem cell-derived organoids in physiologically relevant microenvironments through microengineered organ-chip devices to study tissue morphogenesis and identify biomarkers in diseases of the intestine and lung. When she's not thinking about her research, Estelle enjoys walking her dog, planning her next hike, or trying out new restaurants. ~BME Host: Hugh Lee~ Zoom link: https://purdue-edu.zoom.us/j/94442813985?pwd=VlppMzBRV2ZSWlVJQll4NElyb2dnQT0... BME PhD Preliminary Exam announcement for Luke Brennan (J. Linnes and N. Rodriguez, co-advisors), Wed., Jan. 25, 11:00 a.m., MJIS 2001 and via Zoom. Title of presentation: HPV Rapid Diagnostic Test Development Through Human-Centered Design. Everyone is invited to attend the public presentation. Advisory Committee: Jacqueline Linnes Ph.D., Co-Chair; Natalia Rodriguez Ph.D., Co-Chair; Aaron Ermel M.D.; Monica Kasting Ph.D.; Mohit Verma Ph.D. Abstract: Almost every case of cervical cancer in the United States is medically preventable with proper screening, yet many Americans are insufficiently screened. Over 12 thousand American women suffered from cervical cancer in 2018 causing 4 thousand deaths, with over a third in women who had never received a routine screening test. New, sensitive testing techniques have started to facilitate self-sampling at outpatient clinics and mail-in testing, which ameliorate some barriers to screening. Screening with a rapid diagnostic test (RDT), which can be performed in a variety of settings to deliver results in minutes, could further increasing screening uptake and follow-up care delivery. The goal of this project is to create a sample-to-answer RDT for cervical cancer screening. In the first aim we use interviews and a survey to explore clinician perspectives on current and newly proposed cervical screening methods such as self-sampling, RDTs, and home-based screening. This will result in a user-informed set of technical specifications for device design. The second aim augments a recombinase polymerase assay that isothermally amplifies any of 13 high-risk human papillomavirus (hrHPV) strains with an endogenous *-globin sample control and a simple colorimetric lateral flow assay (LFA) readout. The third aim incorporates this assay onto a paper-based device with a simple resistive heater, lysis buffer, and timers. The resulting test will accept vaginal fluid samples, buffer and lyse the samples, copy any hrHPV DNA present, and report copied DNA through a colorimetric LFA. Zoom link: https://iu.zoom.us/j/5867035107 Prospective BME Faculty Seminar, Wed., Feb. 1, 9:30 a.m. in MJIS 1001 and via Zoom. Wei Ouyang, Postdoctoral Fellow, Bioelectronics, at Northwestern University will present "Integrated Bioelectronic Systems for Biomedical Research and Healthcare: Materials, Electronics, and Computing." Abstract: Probing and modulating life processes in the native state represents a key capability in our quest for a better understanding of life and a higher quality of life. In this talk, I will present implantable and wearable forms of flexible bioelectronic devices developed through a systems approach combining materials, electronics, and computing that open up new opportunities for fundamental biomedical research in unperturbed, naturally behaving animal models and for continuous, ambulatory monitoring of human health. I will first present a new class of wireless, battery-free, fully implantable devices that offer multimodalities and closed-loop functionalities in neuroscience research and the use of this technology for studying auditory-evoked potentials, sleep-wake regulations, seizure treatment, cardiology, and social interactions. Then I will present the translation of this technology in human healthcare using a wearable mechano-acoustic sensing device deployed to about 500 patients as an example, with an emphasis on data analytics for continuous monitoring of COVID-19 and vocal health. I will conclude by discussing future opportunities of my research in both fundamental and translational biomedicine. Bio: Wei Ouyang is currently a postdoctoral fellow supervised by Prof. John A. Rogers at the Querrey Simpson Institute for Bioelectronics, Northwestern University. He received his S.M. degree in Electrical Engineering and Computer Science and Ph.D. degree in Electrical Engineering from the Massachusetts Institute of Technology under the supervision of Prof. Jongyoon Han. He received his B.S. degree in Microelectronics from Peking University, China. His research interests include implantables, wearables, neural engineering, digital health, bioMEMS, and microfluidics. He is a recipient of several prestigious awards, including the Dimitris N. Chorafas Foundation Award, Siebel Scholar (Class of 2016), the Peake Research Prize at MIT, and the Ernst A. Guillemin Thesis Award at MIT. ~BME Host: Hugh Lee~ Zoom link: https://purdue-edu.zoom.us/j/91331613591?pwd=dnY3M1pqTXVVZGdOeklpc2pSR0svUT0... The Great Lakes NSF I-Corps Hub and Purdue I-Corps are offering various workshops in Spring 2023 that can significantly increase the chances of securing federal proof of concept & commercialization grants like SBIR/STTR, PFI-TT that range from $500k to $1.6 million. The historical success rate for Purdue Faculty, who complete the NSF I-corps workshops, and apply for these competitive NSF research commercialization grants is over 90%. Please find details of the workshops below. STEM Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-stem-jumpstart/>: Feb 3 - March 24 Medical Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-medical-jumpstart-i-corps-course/>: Feb 3 - March 24 Purdue I-Corps Discovery, Discovery+<https://www.greatlakesicorps.org/event/winter-2023-purdue-i-corps-discovery/>: Feb 17-March 24; March 31-April 7 Gain new insights about your research, explore the commercial potential, learn about NSF funding opportunities, and increase your industry and professional network. Learn from our NSF-certified instructors, experienced entrepreneurs, and mentors. If a student/Post-doc in your lab is interested in this opportunity and would like to learn more, please reach out to Geetali Pradhan at gpradhan@purdue.edu<mailto:gpradhan@purdue.edu> Purdue I-Corps Great Lakes hub I-Corps (Jumpstart) Discovery Discovery+ STEM specific Medical specific Duration 4 workshops 2 workshops 5 workshops 5 workshops Schedule Feb 17 - March 24, online March 31, April 7, online Feb 3 - March 24, online Feb 3 - March 24, online Team requirement 2-4 2-4 2-4 Affiliation Purdue Univ, any Midwest Univ Purdue Univ, any Midwest Univ Hub-affiliated institutions and other Midwest teams Hub-affiliated institutions and other Midwest teams Prerequisite None Discovery None None Instructors 2-3 2-3 3-6 3-6 Learnings Customer Discovery, Product-Market Fit, and Market Assessment Market size, Commercialization pathway, Commercialization grants Customer Discovery, Product-Market Fit, Market Assessment, Commercialization Pathway Customer Discovery, Product-Market Fit, Market Assessment, Commercialization Pathway Learn more Purdue I-Corps<https://www.greatlakesicorps.org/event/winter-2023-purdue-i-corps-discovery/> STEM Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-stem-jumpstart/> Medical Jumpstart<https://www.greatlakesicorps.org/event/winter-2023-medical-jumpstart-i-corps-course/> Prospective BME Faculty Seminar, Wed., Feb. 8, 9:30 a.m. in MJIS 1001 and via Zoom. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University will present "Traditional and computational development of fluorescence imaging tools for neuroscience" Abstract: Modern basic research in neuroscience aims to dissect neural activity from genetically identifiable neuron populations within dense neural circuits. Such research has relied increasingly on tools that perform optical imaging and optical stimulation. In this area, my lab develops a diverse toolbox that employs multiple engineering disciplines simultaneously. In this talk, I will highlight our recent gains in protein engineering, optical microscopy, and data analysis. The protein tools will attempt to enable multi-channel optical experiments by increasing spectral separation between fluorescent protein sensors and actuators. The microscopy tools will attempt to support fast volumetric imaging experiments that accurately capture neural activity. The data analysis tools will attempt to find neurons and calculate their neural activity from the large datasets resulting from optical imaging experiments quickly and accurately. Lastly, this talk will touch on the future of the protein engineering pipeline seen through the lens of protein tools in neuroscience. Bio: Yiyang Gong obtained his B.S. in Electrical Engineering from the California Institute of Technology. He then obtained his M.S. and Ph.D. in Electrical Engineering from Stanford University, training with Prof. Jelena Vuckovic on plasmonic and photonic crystal optical devices. He trained with Prof. Mark Schnitzer at Stanford University as a postdoc in Biology, developing genetically encoded voltage sensors that are advancing the current generation of neuroscience experiments. His current work focuses on imaging neural activity with a combination of engineered protein sensors, optical microscopes, and computational algorithms. His work has been supported by the Beckman Young Investigator Award, the BRAIN initiative, NIH New Innovator Award, NSF CAREER Award, Sloan Fellowship, and Vallee Young Investigator Award. ~BME Host: Hugh Lee~ Zoom link: https://purdue-edu.zoom.us/j/97275864534?pwd=UFNhaDBadVVxRjVxdE5UOTRlT0trUT0... Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 2 1/18/2023 BME Faculty candidate Dr. Jacob K. Rosenstein, Associate Professor of Engineering, Brown University Dr. Hugh Lee Week 3 1/25/2023 Faculty candidate Sunghee Estelle Park, PhD Candidate and CEMB Fellow, Bioengineering, University of Pennsylvania Dr. Hugh Lee Week 4 2/1/2023 Faculty candidate Dr. Wei Ouyang, Postdoctoral Fellow, Bioelectronics, Northwestern University Dr. Hugh Lee Week 5 2/8/2023 Faculty candidate Dr. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University Dr. Hugh Lee Week 6 2/15/2023 Dr. Ken Yoshida Professor of BME at IUPUI Dr. Young Kim Week 7 2/22/2023 Dr. Rita Patel Associate Professor, Speech & Hearing Sciences + Associate Professor of Otolaryngology-Head & Neck Surgery at IUSM Dr. Young Kim Week 8 3/1/2023 Dr. Joey Wallace Chair and Professor of BME at IUPUI Dr. Young Kim Week 9 3/8/2023 Dr. Hubert Lim Professor, Department of Biomedical Engineering, Otolaryngology, Institute for Translational Neuroscience Scholar, University of Minnesota Dr. Hugh Lee Week 10 3/22/2023 Dr. Daniel DiLorenzo, Assistant Professor, Neurosurgery and Biomedical Sciences, Loma Linda University; Attending Neurosurgeon, Loma Linda VA Medical Center; President Barinetics Corporation Dr. Matthew Ward Week 11 3/29/2023 Dr. Nimmi Ramanujam Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University Dr. Jackie Linnes Week 12 4/5/2023 Dr. Junhong Chen Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory Dr. Chi Hwan Lee Week 13 4/12/2023 Dr. Chien-Chi Lin Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI Dr. Young Kim Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Attachments 2023 CTSI Winter Retreat Flyer v2.pdf Agreement on Deliverables for Credit Procedures - Faculty Instructions Agreement on Deliverables for Credit Procedures - Proxy Instructions BME_Graduate_Research_Credit_Expectatons_Form_Fa22 -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list