[cid:image003.jpg@01D9710F.E876D3D0] BME MONDAY ROUNDTABLE APRIL 17, 2023 DEPUTY HEAD’S NOTE * Congratulations to Drs. Yunjie Tong and Luis Solorio for being promoted to the rank of Associate Professor of Biomedical Engineering with tenure. Congratulations to Drs. Eugenio Culurciello and Craig Goergen for their promotion to the rank of Professor of Biomedical Engineering. Their promotions were approved by Purdue University’s Board of Trustees on Friday (April 14). Here is the News Release, https://www.purdue.edu/newsroom/purduetoday/releases/2023/Q2/faculty-promoti.... * Purdue Spring Fling 2023 will take place on May 25, 2023. After a three-year hiatus caused by the COVID-19 pandemic, the Spring Fling appreciation event for faculty, staff, graduate student staff and retirees will be held from 11:30 am – 4:30 pm May 25 in Memorial Mall. It will offer will offer many of the same activities as in years past, such as a fitness walk, lawn games and disc golf. Volunteers are still needed. For more information, please see https://www.purdue.edu/springfling/ . * If you are interested in nominating an Undergraduate Teaching Assistant (UGTA) for the 2023-24 academic year, please submit your nomination by May 1st for consideration. If you have any questions, you can reach out to Asem Aboelzahab (aboelzahab@purdue.edu<mailto:aboelzahab@purdue.edu>). For more information, please see the following Academic Programs Update. * A number of BME graduate students received 2023 College of Engineering Graduate Students Awards in the categories of teaching, service and research. Congratulations to them and their mentors. They are College of Engineering Magoon Teaching Awards: * Aditya Shanghavi * Jacob Larsen * Emilee Madsen College of Engineering Outstanding Graduate Student Service Award: * Claudia Benito Alston College of Engineering Outstanding Graduate Student Research Award: * Angel Enriquez * Dr. Craig Goergen received an Alumni Award from Washington University in St. Louis where he received his BSBME. Dr. Goergen was also named BMES Conference Co-Chair for the 2025 conference in San Diego. * HEDE Climate Survey. The Weldon School of Biomedical Engineering’s Diversity, Equity and Inclusion (DEI) Steering Committee wans your input on an anonymous all-school climate survey. Please find the QR code on the attached flyer. * The weather has not been on our side. We got some warm and sunny days in the middle of last week. But last week and today have been awful. Hope this is the last time before the coming summer to see freezing temperature. Other than that, enjoy the end of the semester! Important MJIS Alert Starting Monday, May 22nd, Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details. UPCOMING IMPORTANT DATES Week of April 17 Mon., April 17: BME PhD Preliminary Exam Announcement for Kentaro Umemori (D. Little, advisor). Everyone is invited to attend the public presentation beginning at 9:30 AM EST in MJIS 2001. Research Title: The Impact of Polymer on 3D Meltblown Scaffolds and the Epigenome of Adipose-Derived Progenitors Mon., April 17: Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 p.m., R4 101 (Indianapolis) and via Zoom. Will Holland, MD, PhD, Associate Professor of Medicine at Albert Einstein College of Medicine, New York, New York, will present “Glucagon Receptor Antagonism in Beta Cell Regeneration.” Zoom link: https://iu.zoom.us/s/87501979533 Tues., April 18: BME PhD Defense Announcement for Peiyi Zhang (Fang Huang, advisor), 10:00 a.m., MJIS 2001 and via Zoom. Title of Thesis: Single molecule analysis and wavefront control driven by deep learning. Everyone is invited to attend the public presentation beginning at 10:00 a.m. Tues., April 18: BME Master's Defense Announcement for Pankti R. Thakkar (J. Linnes, advisor), 12:00 p.m., BRK 2001 and via Zoom. Thesis Title: Characterization and Development of an Enzymatically Signal Enhanced Lateral Flow Assay Test for HIV using p24 Antigen. Everyone is invited to attend the public presentation beginning at 12:00 pm. Wed., April 19: Weldon School of BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Rachel K. Surowiec, Assistant Professor of Biomedical Engineering, Indiana University Purdue University Indianapolis and Indiana University School of Medicine will present “Seeing the Unseen: Using imaging to uncover tissue-level mechanisms in skeletal disease.” Wed., April 19: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. Dr. Kinam Park, Showalter Distinguished Professor of Biomedical Engineering at Purdue will present Drug Delivery Systems: The Revolution-Evolution Cycle. Zoom link: https://bit.ly/3HsTf5R Seminars are sponsored by Plexon and the Center for Paralysis Research at Purdue. Thurs., April 20: Seminars in Hearing Research at Purdue (SHRP), 10:30 a.m., LYLE 1150 and via Zoom. Meredith Christine Ziliak will present “Examining the middle latency response in the d-galactose model of aging.” Thurs., April 20: BME Master's Defense Announcement for Riley J. Brown (J. Linnes, advisor). Everyone is invited to attend the public presentation beginning at 12:00 pm in BRK 1001 and via Zoom. Title: Characterization and Implementation of Screen Printed, Flexible PTC Heaters for Portable Diagnostic Testing Fri., April 21: Upcoming Indiana Life Sciences Collaboration Conference: Digital Health – The “Buzz” and the Reality,” 8:00 a.m. – 5:00 p.m., Taft-Regions Tower, Indianapolis. The FDA defines digital health as “mobile health (mHealth), health information technology (IT), wearable devices, telehealth and telemedicine, and their relationship to personalized medicine”. The pandemic accelerated its adoption across healthcare. This conference will take a look at the progress that has actually been made, further opportunities and issues still needing to be ironed out so digital health can reach its full potential. For more information and to register, go to: https://kelley.iu.edu/faculty-research/centers-institutes/business-of-life-s... Upcoming important deadlines and info. Tues., Apr. 25-Thurs., Apr. 27: Artificial Intelligence in Healthcare Innovation: Moving from Reactive to Proactive Conference hosted by the Regenstrief Institute and Indiana University School of Medicine, Department of Biostatistics & Health Data Science, April 25-27. Registration is free, and available at regenstrief.org/ai-conference-2023 Thurs., Apr. 27: Purdue Computational Imaging Seminar, 10:00 a.m., Fowler Hall. Dr. Joseph M. Howard, NASA, will present “Current and Future NASA Space Telescopes.” Free admission, but registration required: https://forms.gle/NtLyFzVPbrUAY8uM8 Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Fri., May 12: Diabetes Data and Hypothesis Hub (D2H2) Seminar, 12:00 p.m., via Zoom. Dr. Avi Ma’ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration.” Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Academic Programs Update If you are interested in nominating an Undergraduate Teaching Assistant (UGTA) for the 2023-24 academic year, please do so using the link below: https://purdue.ca1.qualtrics.com/jfe/form/SV_9ynOH9kOdtPsWmq Please submit the survey by May 1st for consideration. If you have any questions, you can reach out to Asem Aboelzahab (aboelzahab@purdue.edu<mailto:aboelzahab@purdue.edu>). If you have graduate students in your lab who may be interested in serving as a TA for the coming school year, we need your nominations (including their additional background information) by May 1st, 2023. If your student has a fellowship for the upcoming academic year, we ask that you please refrain from nominating them at this time. In the Weldon School we do our best to distribute teaching assignments to the students who are the best fit for each course. Therefore, if you have any graduate students (residents or international) who you would like to be considered for a TA appointment in the 2023-2024 year, please complete the following survey with the required information for determining best fit: https://purdue.ca1.qualtrics.com/jfe/form/SV_7WjqEDEX5RVlk7Y A description of courses is attached for your reference. If you are nominating an international student who has not taken the Oral English Proficiency Test (OEPT), please contact Asem Aboelzahab aboelzahab@purdue.edu<mailto:aboelzahab@purdue.edu>) to schedule your student for the test ASAP. Note that preference will be given to students in the graduate programs of the Weldon School. · Drop-in virtual help sessions can assist faculty with end-of-semester Brightspace, other instructional technology - Purdue University Online - Purdue University<https://discover.online.purdue.edu/news/2023/04/05%20-%20Drop-in%20virtual%20help%20sessions%20can%20assist%20faculty%20with%20end-of-semester%20Brightspace,%20other%20instructional%20technology.php?image> Full Term (16 Weeks) and Second Eight-Week Session grade entry (meeting between March 6 and May 6) begins at 8 a.m. April 21 and ends promptly at 5 p.m. May 9. 1. Now is the perfect time for faculty to take the 15 minutes to get all their required certifications up to date BEFORE the deadline approaches. * FERPA * GLBA * Data Handling * Protecting SSNs 2. This page<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html> provides myPurdue grade entry instructions. 3. This page<https://www.purdue.edu/brightspace/Docs/Grades/SubmitFinalGradesToBanner.php> provides BrightSpace final grade submission instructions. 4. Those not making the deadline can use the Grade Change Workflow. * Instructions may be found here<https://www.purdue.edu/registrar/faculty/grading/Grade_Change_Workflow.html>. 5. Lastly but still very important, any faculty that assigned an Incomplete in Spring 2022 has until Tuesday, May 5 at 5pm to use the Grade Change Workflow to submit a completion grade. If not submitted by this deadline it will revert to an IF grade for the student. * Any extension requests for students that faced obstacles outside of their control should be submitted to @Shomaker, Lori<mailto:lshomake@purdue.edu> no later than Friday, May 5 for processing. Graduate Office Update Dear BME Faculty, Weldon BME PhD students performing research in one of these areas - cardiovascular devices, implantable biomaterials design, drug-delivery systems, or biochemical sensors – are eligible for nomination for the Ronald W. Dollens Scholarship. For the nomination, we will need from you a short description (less than 250 words) of an outstanding, current graduate student in your lab who is excelling in research performance and service to the department. In your description, please mention/include the following: * Student’s year in the PhD program (1st year, 2nd year, etc.) * Brief description of outstanding research performance * Brief description of service to the department * Mention of recent awards, presentations made at conferences, papers authored, etc., that you think help describe the student’s contributions * Student’s CV Please send the nomination to tsiemers@purdue.edu<mailto:tsiemers@purdue.edu> by Sunday, May 21st. The Ronald W. Dollens Scholarships in Life Sciences will be awarded based on academic merit to two deserving graduate students in the Weldon School of Biomedical Engineering who meet the criteria and are selected. The scholarship award is $5,000 with half being awarded in the Fall 2023 semester and half in the Spring 2024 semester. If you have any questions, please don’t hesitate to reach out. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. BMEGSA General Body Meetings – All BME graduate students are welcome, and encouraged to attend! Upcoming meetings: Thursday, April 20th 3:30PM-4:30PM All meetings are held in MJIS 2001 in person only. Research Update To safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and “hidden” predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned. https://www.science.org/content/article/fast-growing-open-access-journals-st... https://retractionwatch.com/2023/03/21/nearly-20-hindawi-journals-delisted-f... Participants needed for a Motor Function Study, “Development of a Diagnostic System for Assessment of Motor Impairment,” IRB# IRB-2022-1299. See below for details. Resources and further information BME PhD Preliminary Exam Announcement for Kentaro Umemori (D. Little, advisor), Mon., April 17. Everyone is invited to attend the public presentation beginning at 9:30 AM EST in MJIS 2001. Research Title: The Impact of Polymer on 3D Meltblown Scaffolds and the Epigenome of Adipose-Derived Progenitors. Thesis Committee Members: Dr. Dianne Little D.V.M. Ph.D. (Chair); Dr. Deva Chan Ph.D.; Dr. Luis Solorio Ph.D.; Dr. Vikki Weake Ph.D. Abstract: Over 460,000 rotator cuff tendon tears occur annually in the US, but even after surgery, the retear rate is up to 90% for massive tears. To augment the repair process, tendon tissue engineering approaches seek to improve these outcomes using biomimetic scaffolds. Currently, electrospinning is a common strategy to fabricate scaffolds. However, this process is difficult to translate due to difficulties in scalability and repeatability. This led to the development of 3D meltblowing (3DMB) which introduces a robotic collector that can produce scaffolds at high speeds with highly organized fibers. My preliminary data demonstrate cell proliferation and collagen deposition in 3DMB poly-L-lactic acid and poly-ε-caprolactone scaffolds cultured with adipose derived stem cells (ASCs). However, there were substantial differences in neo-collagen alignment and tendon-related proteomic datasets between polymers. These disparities suggest that biophysical and biochemical cues related to the polymer type are the underlying cause. However, how these cues promote transition of the ASC epigenome towards those of tendon fibroblasts in response to biomaterials is unknown. Therefore, my overall hypothesis is that the specific polymer used for production of 3DMB scaffolds is critical for promotion of a tendon-related epigenetic landscape in ASCs. To test this hypothesis, I propose the following Aims. Aim 1: I will perform epigenetic profiling of ASCs and tendon fibroblasts to pinpoint the epigenetic markers related to tendon. Aim 2: I will perform a polymer screen and epigenetic analysis of 3DMB scaffolds to identify the impact of polymer type on tendon-related epigenetic marks. Collectively, this study will provide a template for the modification of epigenetic processes to stimulate ASC differentiation to tendon fibroblasts and will significantly advance the understanding of the influence of polymer type on the epigenome during engineered tendon development. BME PhD Defense Announcement for Peiyi Zhang (Fang Huang, advisor), Tues., April 18, 10:00 a.m., MJIS 2001 and via Zoom. Title of Thesis: Single molecule analysis and wavefront control driven by deep learning. Everyone is invited to attend the public presentation beginning at 10:00 a.m. Thesis Committee members: Fang Huang (chair), Eugenio Culurciello, Charles Bouman, Daniel Suter, David Umulis, Tongcang Li Abstract: Analyzing single molecule emission patterns plays a critical role in retrieving the structural and physiological information of their tagged targets, and further, understanding their interactions and cellular context. These emission patterns of tiny light sources (i.e. point spread functions, PSFs) simultaneously encode information such as the molecule’s location, orientation, the environment within the specimen, and the paths the emitted photons took before being captured by the camera. However, retrieving multiple classes of information beyond the 3D position from complex or high-dimensional single molecule data remains challenging, due to the difficulties in perceiving and summarizing a comprehensive yet succinct model. We developed smNet, a deep neural network that can extract multiplexed information near the theoretical limit from both complex and high-dimensional point spread functions. Through simulated and experimental data, we demonstrated that smNet can be trained to efficiently extract both molecular and specimen information, such as molecule location, dipole orientation, and wavefront distortions from complex and subtle features of the PSFs, which otherwise are considered too complex for established algorithms. Single molecule localization microscopy (SMLM) forms super-resolution images with a resolution of several to tens of nanometers, relying on accurate localization of molecules’ 3D positions from isolated single molecule emission patterns. However, the inhomogeneous refractive indices distort and blur single molecule emission patterns, reduce the information content carried by each detected photon, increase localization uncertainty, and thus cause significant resolution loss, which is irreversible by post-processing. To compensate tissue induced aberrations, conventional sensorless adaptive optics methods rely on iterative mirror-changes and image-quality metrics to compensate aberrations. But these metrics result in inconsistent, and sometimes opposite, metric responses which fundamentally limited the efficacy of these approaches for aberration correction in tissues. Bypassing the previous iterative trial-then-evaluate processes, we developed deep learning driven adaptive optics (DL-AO), for single molecule localization microscopy (SMLM) to directly infer wavefront distortion and compensate distortion near real-time during data acquisition. our trained deep neural network monitors the individual emission patterns from single molecule experiments, infers their shared wavefront distortion, feeds the estimates through a dynamic filter (Kalman), and drives a deformable mirror to compensate sample induced aberrations. We demonstrated that DL-AO restores single molecule emission patterns approaching the conditions untouched by specimen and improves the resolution and fidelity of 3D SMLM through brain tissues over 130 µm, with as few as 3-20 mirror changes. Zoom link: https://purdue-edu.zoom.us/j/92016185985 BME Master's Defense Announcement for Pankti R. Thakkar (J. Linnes, advisor), Tues., April 18, 12:00 p.m., BRK 2001 and via Zoom. Thesis Title: Characterization and Development of an Enzymatically Signal Enhanced Lateral Flow Assay Test for HIV using p24 Antigen. Everyone is invited to attend the public presentation beginning at 12:00 pm. Thesis Committee: Jacqueline Linnes, PhD, Chair; Lia Stanciu, PhD; Scott Bolton, PhD Abstract: In 2021, an estimated 1.5 million people were diagnosed with HIV globally, increasing the total to 38.4 million people. Approximately 16% of this population were unaware of their infected status and required HIV testing, which is a critical first step in HIV prevention, treatment, and care [1]. Hence, there is a need to develop a rapid, user-friendly, and cost-effective point-of-care test for HIV detection. The time between HIV infection and a detectable host HIV antibody concentration can extend up to 90 days. By incorporating more sensitive testing for the HIV p24 antigen on the virus, the diagnosis lag can be reduced to 17 days [2]. This window could be further shortened by using horseradish peroxidase (HRP) enzyme as a signal enhancement technique. The work herein focuses on developing an enzymatically signal-enhanced lateral flow assay test for the p24 antigen to detect HIV during the acute phase of infection. Conjugation chemistry for the sandwich assay was characterized using DLS and UV-Vis. Dot blots were then used to assess and enhance the functionality of the individual components via a visual color gradient formed by the protein coupled with antibody-conjugated gold nanoparticles. A quantitative analysis was performed using ImageJ software through signal pixel intensity analysis. A limit of detection (LoD) of 6 ng/mL was obtained for the detection of p24 antigen in the patient sample. This LoD was improved to 0.2 ng/mL by incorporating HRP signal enhancement with diaminobenzidine substrate [3]. This 30x signal improvement could drive down the LoD even further to improve the sensitivity of the commercial p24 antigen tests. Different fabrication and scalability studies were performed to produce a cost-efficient, fully functional prototype of a paper-based lateral flow device incorporating the signal-enhanced p24 assay. This study serves as a solid foundation to research focused on creating more efficient point-of-care tests that can be used in resource-limited settings to provide early detection of HIV for the 6 million individuals who are currently unaware of their HIV status. [1] October 25, 2021, “Global HIV/AIDS Organizations.” [2] “Types of HIV tests, HIV basics | HIV/AIDS | CDC.” [3] KM. Byers et al., ACS Omega 5, no. 9 (March 10, 2020): 4673-81 Zoom Link: https://purdue-edu.zoom.us/j/8181492040 Weldon School of BME Research Seminar, Wed., April 19, 9:30 a.m., MJIS 1001 and via Zoom. Rachel K. Surowiec, Assistant Professor of Biomedical Engineering, Indiana University Purdue University Indianapolis and Indiana University School of Medicine will present “Seeing the Unseen: Using imaging to uncover tissue-level mechanisms in skeletal disease.” Abstract: Americans are experiencing fragility fractures at historically high rates. Strategies to define the risk of fracture and to develop drugs that reduce this risk over the past 50 years have focused on imaging bone's mineral phase and maximizing bone mass, respectively. Unfortunately, this mineral-centric focus has led to marginal success, suggesting we have not fully described the regulatory mechanisms underlying skeletal homeostasis or identified the appropriate biomarkers to predict failing bone health. An arm of my program is pursuing the bold hypothesis that the non-mineral components of bone (specifically water) have an underlying mechanistic effect on bone fragility and can therefore serve as a biomarker of fracture risk and novel therapeutic target to 'flatten the curve' of fracture in our society. In doing so, my lab seeks to reveal the complex interplay between bone composition and function using novel imaging and spectroscopy techniques to better understand bone biology and why a bone fails. This seminar will cover two examples of how we are identifying new imaging biomarkers to improve fracture prediction that is guiding how we therapeutically modify bone: 1) using a novel ultra-short echo time magnetic resonance sequence (UTE-MRI) to illuminate the role of bone water during disease progression and 2) using high-resolution peripheral quantitative computed tomography (HR-pQCT) to track individual cortical pore (pathological holes within bone) dynamics. Biography: Dr. Rachel Surowiec is currently an Assistant Professor within the Biomedical Engineering Department (IUPUI) and Radiology and Imaging Sciences (Adjunct, Indiana University School of Medicine (IUSM)). Following her Master’s in Biomechanics, she worked as a Senior Research Scientist in the Dept. of Imaging Research at the Steadman Philippon Research Institute in Vail, CO. She received her Ph.D. in Biomedical Engineering with a Biomedical Imaging Concentration at the University of Michigan. Her first Postdoctoral appointment was at the Center for Molecular Imaging, Department of Radiology at the University of Michigan, followed by a postdoctoral appointment within the Depts. of Anatomy, Cell Biology, and Physiology (IUSM) and Biomedical Engineering (IUPUI). Her research interests include imaging biomarker development to improve upon fracture prediction in skeletal disorders. ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09 NOTE: Students registered for the seminar are expected to attend in-person. Seminars in Hearing Research at Purdue (SHRP), Thurs., April 20, 10:30 a.m., LYLE 1150 and via Zoom. Meredith Christine Ziliak will present “Examining the middle latency response in the d-galactose model of aging.” Abstract: Age-related hearing loss (ARHL) is the most common sensory disorder in people over 60 years old and is known to result from auditory processing dysfunction induced by metabolic disorder in the central auditory system (CAS). However, despite its prevalence, ARHL and its effects on the CAS have not yet been comprehensively characterized. Possible reasons for this deficit could be the challenges of studying ARHL. First, any damage to structures or processes upstream of the CAS, such as noise exposure to the inner ear, ambiguates any results measured in the CAS. This confounding factor is practically unavoidable when studying naturally aged subjects. Additionally, using naturally aged animal subjects is costly both in time and funds. To mitigate these complications, we have used the d-galactose model of aging which produces comparable metabolic biomarkers of ARHL and other aging disorders in central, but not peripheral auditory structures and processes, allowing us to isolate age-related damage to the CAS in young subjects. In this ongoing study, we have used the d-galactose model alongside a click train variation stimulus to better characterize metrics of ARHL in the CAS. We have focused our analyses on the effects of aging on the middle latency response. Our preliminary results will be discussed, and future directions explored. Zoom link for remote attendees: https://purdue-edu.zoom.us/j/4326340458 Meeting ID: 432 634 0458 The working schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/5/VzPUtXKo0Dowllp_TK_BrQ/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX3NjaGVkdWxl> The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> BME Master's Defense Announcement for Riley J. Brown (J. Linnes, advisor). Thurs., April 20. Everyone is invited to attend the public presentation beginning at 12:00 pm. In BRK 1001 and via Zoom. Title: Characterization and Implementation of Screen Printed, Flexible PTC Heaters for Portable Diagnostic Testing Thesis Committee: Dr. Jacqueline Linnes (chair), Dr. Lia Stanciu, and Dr. Orlando Hoilett Abstract: The 2020 pandemic emphasized the need for accessible and accurate point-of-care diagnostic tests. With the continued development of isothermal nucleic acid amplification tests, this can be achieved. A requirement of these tests includes heating and holding a specific temperature, in this case, 65℃ for 30 minutes, for amplification to occur. To achieve this, heaters often require external feedback to control the temperature; bringing up the device’s cost. Several self-regulating heaters have been made with materials having a positive thermal coefficient of resistance eliminating the need for complex circuitry. With this property, point-of-care diagnostic tests can be simplified and made more accessible. In this study, ink-based positive thermal coefficient of resistance heaters are developed and characterized using the scalable method of screen printing to achieve 65℃ and aid in the detection of SARS-CoV-2. Various curing methods and screen-printing parameters were evaluated to improve the stability and understanding of the reproducibility of the heaters. The longevity of the heaters was evaluated with oxidation studies and a COMSOL model was created to study the heat transfer within the device. Furthermore, the heaters were successfully implemented into a second-generation electronic point-of-care diagnostic device. Detection of SARS-CoV-2 using a self-regulating heater removes the need for complex circuitry, improving the accessibility of point-of-care tests with the potential to be expanded to a wide range of pathogen detection. Zoom link: https://purdue-edu.zoom.us/j/95178617829?pwd=QnlmMmIrZU9zWWNqZ2I2eFNaMW9Edz0... Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha@purdue.edu<mailto:ashangha@purdue.edu>. Purdue Computational Imaging Seminar, Thurs., Apr. 27, 10:00 a.m., Fowler Hall. Dr. Joseph M. Howard, NASA, will present “Current and Future NASA Space Telescopes.” Free admission, but registration required: https://forms.gle/NtLyFzVPbrUAY8uM8 Abstract: Astronomy is arguably in a golden age, where current and future NASA space telescopes are expected to contribute to this rapid growth in understanding of our universe. A summary of our current space assets will be given, including the James Webb Space Telescope (JWST), our most recent addition. Future telescopes will also be discussed, including the Nancy Grace Roman Space Telescope (RST), the Laser Interferometer Space Antenna (LISA), as well as mission concept studies being prioritized in the 2020 Decadal Survey in Astrophysics. Bio: Joseph M. Howard received BS in physics from the US Naval Academy in Annapolis, Maryland, and his Ph.D. in Optical Design from The Institute of Optics, University of Rochester, in Rochester, NewYork. He now serves as an optical designer for NASA, working on projects including the James Webb Space Telescope, the Roman Space Telescope, LISA, and other future space missions. Joe lives with his wife, two children, and dog and cat in Washington DC. Event Inquiry: Professor Stanley Chan (stanchan@purdue.edu) Diabetes Data and Hypothesis Hub (D2H2) Seminar, Fri., May 12, 12:00 p.m., via Zoom. Dr. Avi Ma’ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration.” Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Abstract: This seminar will discuss two new interactive bioinformatics software tools that integrate knowledge from many NIH funded and other key resources for hypothesis generation. The Diabetes Data and Hypothesis Hub (D2H2) is a platform that integrates tools and datasets related to diabetes research into one integrative platform. The Playbook Partnership Workflow Builder (PPWB) is a system that enables novice users to created bioinformatics workflows by exploring a network of distributed but connect microservices. These two new tools will be demonstrated through a variety of use cases with applications that prioritize personalized drugs and targets for kidney disease, diabetes, and pan-cancer. Bio: Dr. Ma’ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences, Director of the Mount Sinai Center for Bioinformatics, and a faculty member of the Department of Artificial Intelligence and Human Health at the Icahn School of Medicine at Mount Sinai in New York City. The Ma'ayan Laboratory applies computational methods to study the complexity of regulatory networks in mammalian cells. His research team develops software systems to help experimental biologists form novel hypotheses from high-throughput data with a focus on drug and target discovery through machine learning and other statistical methods. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Attachments BME Course Descriptions 2023ClimateSurveyFlyer_Emailing.pdf -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list