[cid:image003.jpg@01D94A89.4FA33010] BME MONDAY ROUNDTABLE FEBRUARY 27, 2023 DEPUTY HEAD'S NOTE * Dr. Taeyoon Kim graciously accepted the co-chair role for the Computational Biomedicine research area after I became the Deputy Head. Since becoming the new area co-chair, he and Dr. Elsje Pienaar have worked together to develop a ranked list of distinguished seminar speakers for the Spring 2024 session. Thanks go out to them. Now the area faculty are working on getting the invitations out. Getting distinguished and excellent speakers to our school and on our campus is something important and beneficial to our school facing outwardly. * Four items were covered in last Friday's Engineering Leadership Team meeting. They are 1) launch of Purdue International Scholar Assistance (PISA); 2) CoE application and admission; 3) CoE COACH survey; and 4) raise of the graduate salaries. * PISA is a new, more centralized service of ISS provided to non-US Purdue-sponsored international faculty, staff, post-docs, and visiting scholars. Beginning in July 2023, PISA will serve as administrative liaisons for our international faculty, staff, postdocs, and scholars, and their hosts and hiring units. Our CoE will be the test unit, which will start the adaption on March 1st, and anticipated to conclude on April 1. Beginning March 26, all J-1 visa requests will be directed to PISA; Permanent residence applications will still be handled by Cris Crozier, who will remain managing these until October; changes on H1-B requests (faculty) will apply to new faculty offers after March 26. For more information, please stay tuned for more information from the ISS over this semester. I am also happy to get you connected with the right people at ISS. * The CoE target enrollment for the new cycle (2023 - 2024) is 2300. Up to now, the admissions have been down a bit comparing to this time last year. Applications are down among residents and international; and up among domestic non-residents; the number of women is up for both applicants and admits; and URM are up for both applications and admits; most of the merit-based awards are out by now. * COACH survey: CoE 56% respondence, entire Purdue 45%. I am pleased to report to you that we are one of the three CoE units with above 50% response rate. Kudos to all of you. The analysis is completed by a task force and the analysis results should be out soon. Focus groups will be soon formed to strategize the improvements. I am happy to discuss with you about the survey results once you have a read-out. * Drs. Tami Kinzer-Ursem and Mike Heinz have been actively working with the Associate Dean for Graduate Education on the matter of raising graduate salaries. Stay tuned for more information. * Some of you have sent me requests for supporting/nominating/endorsing applications of yours and/or your postdocs and students for college-level, campus-wide, and external opportunities for career betterment. Thank you! For all, please do not hesitate to take such actions. I often take an approach of handling those requests upon their arrivals. UPCOMING IMPORTANT DATES Week of February 27 Mon., Feb. 27: Center for Diabetes and Metabolic Diseases Pilot & Feasibility Grants, Letter of Intent due to Jeffrey Elmendorf (jelmendo@iupui.edu<mailto:jelmendo@iupui.edu>) by 5:00 p.m. See attachments for details. Mon., Feb. 27: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 p.m., via Zoom. Ananta Addala, DO, MPH, Assistant Professor of Pediatrics, Division of Endocrinology & Diabetes, Lucile Packard Children's Hospital, Stanford University, will present "Disparities in Diabetes Technology: A Roadmap to Equity." Zoom link: https://iu.zoom.us/s/87501979533 Tues., Feb. 28: AAE Spring 2023 Colloquium Series, at 3:00 p.m. in ARMS 1103. Christian Franck, Bjorn Borgen Professor, Panther Program Director, and Director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison will present "Cellular NeuroMechanics-Concussions, Traumatic Brain Injury and the Mysterious Havana Syndrome." Wed., March 1: Weldon School of Biomedical Engineering Distinguished Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Joseph Wallace, PhD, Chair of the Department of Biomedical Engineering and Professor of Biomedical Engineering, Indiana University School of Medicine will present "Targeting Tissue Quality as an Interventional Approach to Improve Bone Material Properties and Fracture Resistance." Wed., March 1 and Fri., March 3: ABRCM365: Career & Research Summit, 3:00-6:00 p.m., Virtual. Are you interested in the current state of STEM careers and research? Identifying areas of opportunity and adopting strategies to meet the needs of the current landscape in STEM requires maintaining a diligent focus on current research and viable pathways. The ABRCM365 Career & Research Summit is a new 2-day virtual experience. For more information and to register, visit: https://abrcms.org/index.php/career-research-summit Also, see attached flyer. Wed., March 1: BME Master's Defense Announcement for Cole B. Reynolds (J. Paul Robinson, advisor), 1:00 p.m., BRK 2001 and via Zoom. Title: Novel Microfluidic Device for In-Field Purification, Amplification, and Detection of DNA from Mycotoxin-Producing Fungi. Wed., March 1: BME PhD Final Exam Announcement for Emma Vanderlaan (S. Harbin, advisor), 1:00 p.m., MJIS 2001 and via Zoom. Title: Engineering Design of Novel 3D Microphysiological System and Sensor for Functional Assessment of Pancreatic Beta-Cells. Thurs., March 2: Special BME Seminar, 9:15-10:15 a.m., MJIS 2001. Makito Miyazaki, PhD, Department of Physics at Kyoto University in Japan will present "Reconstitution of Actin Cytoskeletal Dynamics and Functions. This seminar will also be available via Zoom. Thurs., March 2: BME PhD Defense Announcement for Jordanna Payne, 11:00 a.m., MJIS 2001 and via Zoom. This defense is open only to those who have signed the Lilly NDA. Title: The development, validation, and characterization of an ex-vivo porcine full thickness skin model for the study of the subcutaneous compartment. Thesis Committee: Luis Solorio, Chair; Adrian Buganza Tepole; Sherry L. Harbin; Kathy D. Miller. Zoom link: https://purdue-edu.zoom.us/j/92039572699 Thurs., March 2: BMS 692/CPB 697 Graduate Seminar, 12:30 p.m., LYNN 1136 and via Zoom. Presenters include: · Courtney Sweeney - Resident, CPB/ADDL, "Anaplastic Meningioma with Pulmonary Metastasis in a Dog" · Rahaf Salim - Graduate Student, BME, "Non-invasive Joint Injury Induced-Model of Post-Traumatic Osteoarthritis" · Cassie Powers - Resident, CPB/ADDL, "Metastatic Gastrointestinal Leiomyosarcoma in a Quarter Horse" Zoom link: https://purdue-edu.zoom.us/j/6308671867 Upcoming important deadlines and info. Wed., March 8: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. Robert F. Hunt, PhD, Associate Professor of Anatomy and Neurobiology and Director of UCI Epilepsy Research Center, UC Irvine, will present "Reconstructing inhibitory circuits in an injured brain." The Seminar for Neurotrauma and Diseases is organized by the Center for Paralysis Research and is sponsored by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. Zoom link: https://bit.ly/3HsTf5R Fri., March 10: BME PhD Defense announcement for Nathaniel J. Smith (G. Hutchins and C. Goergen, co-advisors), 7:45 a.m., MJIS 2001 and via Zoom. Title of presentation: "Quantitative Modeling of PET Images in the Diagnostic Assessment of Brain and Prostate Cancer." Mon., March 13 - Fri., March 17: Purdue University Spring Break Tues., March 14: MJIS Air Handling Shutdown, beginning at 7:30 AM and lasting until approx. 3:00 PM for preventative maintenance of the building's air systems. This includes air ventilation supplies to all public, classroom and research areas, including chemical fume hoods. There should be NO chemicals used anywhere! All chemical fume hood activity should terminate by 5 PM Monday March 13th. You must make sure all chemical containers are sealed at that time. Chemical fume hoods will have notices posted - do not resume activity until BME staff have verified that work is complete, and have removed postings. Wed., March 22: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Brad Duerstock, PhD, Professor of Practice for the Weldon School of Biomedical Engineering at Purdue will present "Detection of autonomic dysreflexia in persons with spinal cord injury using noninvasive sensors." The Seminar for Neurotrauma and Diseases is organized by the Center for Paralysis Research and is sponsored by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. Zoom link: https://bit.ly/3HsTf5R Mon., March 27: Special BME Seminar, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Thurs., March 30-Fri., March 31: 18th Annual Garnet E. Peck Symposium, Purdue Department of Industrial and Physical Pharmacy, Stewart Center and Purdue Memorial Union. 1-1/2 day symposium to showcase advances in pharmaceutical manufacturing, with sessions focusing on biologics and small molecules. Presentations include the latest developments on excipients and continuous manufacturing, novel processing technologies as well as a poster session and 3-minute student thesis competition. Registration is now open: http://www.purdue.edu/conferences/Peck2023 . There is a $15 registration fee. See attached flyer. Wed., Apr. 5: Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Committee Updates Graduate Office Update Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. BMEGSA General Body Meetings - All BME graduate students are welcome, and encouraged to attend! Upcoming meetings: Friday, March 31st 12:30PM-1:30PM Thursday, April 20th 3:30PM-4:30PM All meetings are held in MJIS 2001 in person only. Awards season is upon us and we will be asking for several nominations with varying deadlines over the next month. Below is a quick snapshot of all those awards and deadlines. More detailed emails for each award will be sent separately that will list the criteria and materials needed for the nomination. Two of them look similar (Dissertation and Outstanding Graduate Researcher) so we wanted to make sure that you knew they were actually two separate awards. * NEW COE Distinguished Dissertation Thesis Award (Faculty Nominated Award)-Due March 1st * Outstanding Service Award (Student Nominated Award)-Due March 1st * Outstanding Post Doc Award -Nomination process and due date to be determined Let me know if you have any questions (tsiemers@purdue.edu). Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Mar 10 DUE: All Master's students to be decisioned as either admit, deny or hold Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Resources and further information AAE Spring 2023 Colloquium Series, Tues., Feb. 28, 3:00 p.m. in ARMS 1103. Christian Franck, Bjorn Borgen Professor, Panther Program Director, and Director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison will present "Cellular NeuroMechanics-Concussions, Traumatic Brain Injury and the Mysterious Havana Syndrome." Abstract: Current prediction, prevention and diagnosis strategies for mile traumatic brain injuries, including concussions, are still largely in their infancy due to a lack of detailed understanding and resolution of how physical forces give rise to tissue injury at a cellular level. In this talk I will present some recent work on our current understanding of the origin of concussions and traumatic brain injuries and how cells in the brain interpret and react to the physical forces of trauma. Specifically, I will show that the path to a better understanding of traumatic injuries involves addressing a variety of finite deformation, rate-dependent soft matter and cell mechanics problems along the way. Finally, I will provide an update on how our current understanding of the cellular neuromechanics cannot only help shed light on improving our prediction of TBI but also enable us to dissect the physical origin of emerging injuries such as the Havana Syndrome. Biography: Christian Franck is a mechanical engineer specializing in cellular biomechanics and new experimental mechanics techniques at the micro and nanoscale. He received his B.S. in aerospace engineering from the University of Virginia in 2003, and his M.S. and Ph.D. from the California Institute of Technology in 2004 and 2008. Dr. Franck held a post-doctoral position at Harvard investigating brain and neural trauma. He was an assistant and associate professor in mechanics at Brown University from 2009 - 2018, and is now the Bjorn Borgen Professor in Mechanical Engineering at the University of Wisconsin-Madison. His lab at the University of Wisconsin-Madison has developed unique three-dimensional full-field imaging capabilities based on multiphoton microscopy and digital volume correlation. Current application areas of these three-dimensional microscopy techniques include understanding the 3D deformation behavior of neurons in the brain during traumatic brain injuries, and the role of non-linear material deformations in soft matter. He is the acting director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison and the ONR-funded Physics-based Neutralization of Threats to Human Tissues and Organs (PANTHER) program, which consists of over 24 PIs nationwide. Key objectives of the Panther program are in better detection, prediction, and prevention of traumatic brain injuries by providing accelerated translation from basic science discovery to civilian and warfighter protection solutions. Weldon School of Biomedical Engineering Distinguished Seminar, Wed., March 1, 9:30 a.m. in MJIS 1001 and via Zoom. Joseph Wallace, PhD, Chair of the Department of Biomedical Engineering and Professor of Biomedical Engineering, Indiana University School of Medicine will present "Targeting Tissue Quality as an Interventional Approach to Improve Bone Material Properties and Fracture Resistance." Abstract: The Bone Biology and Mechanics Laboratory (BBML) at IUPUI is committed to improving our understanding of how the body works through innovative preclinical and clinical research. The lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass) in the context of disease and treatment. We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's rich tissue hierarchy. Our long-term goal is to use combinatorial treatments targeting deficiencies in bone mass/quantity and bone tissue quality in complex disease states that have musculoskeletal complications leading to fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations in diseases including diabetes and chronic kidney disease. Biography: Joseph Wallace is a Professor and Chair of the Department of Biomedical Engineering at Indiana University-Purdue University Indianapolis (IUPUI). He graduated with a B.S in Aerospace Engineering from Georgia Tech in 2002 before attending the University of Michigan for his PhD studies in Biomedical Engineering. After earning his PhD in 2007, he chose to remain at Michigan for a Postdoctoral Fellowship in the Department of Chemistry with funding from an NIH F32 individual postdoctoral award. He joined the BME faculty at IUPUI in September 2010 and has developed an active research program in the areas of bone mechanics and mechanobiology. He is currently funded as Principal Investigator by grants from NIH, NSF, and the Department of Veterans Affairs with several other co-Investigator grants from NIH and the VA. His lab is actively looking to grow so please reach out if interested in a funded PhD or postdoctoral position. ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09 NOTE: Students registered for the seminar are expected to attend in-person. BME Master's Defense Announcement for Cole B. Reynolds, Wed., March 1, 1:00 p.m., BRK 2001 and via Zoom. Title: Novel Microfluidic Device for In-Field Purification, Amplification, and Detection of DNA from Mycotoxin-Producing Fungi. Advisory Committee: J. Paul Robinson, Chair; Euiwon Bae; Jacqueline Linnes Abstract: Mycotoxins are toxic molecules produced by fungi and are harmful to human health when ingested. Mycotoxins produced by fungi that infect food crops can enter the food stream directly in manufactured produces (foods like bread) or indirectly through animal feed. Detection of mycotoxins is commonly performed after harvesting and processing of the crops because mycotoxins can increase in concentration during these steps. However, if farmers could detect the toxin-forming fungi prior to harvesting, growers can reduce cross-contamination, save wasted resources used in harvesting and processing of infected crops, and increase food safety and security. Fusarium graminearum is a fungal species that infects cereal crops and produces deoxynivalenol (DON), a harmful mycotoxin called vomitoxin. Because Fusarium graminearum has a large economic impact in the United States and globally on wheat and barley markets, it was selected as a proof-of-concept for the detection assay. For detection of fungus to be useful in determining infected areas of fields, the device must be inexpensive and portable. A low-cost, portable microfluidic device was designed to both extract the fungal DNA from wheat samples and perform a fluorescence-based loop-mediated isothermal amplification (LAMP) assay to detect the fungal DNA. Contaminated wheat samples were used to demonstrate the effectiveness of the device. The device was able to detect Fusarium graminearum in the wheat samples at concentrations relevant to DON concentration limits set forth by the U.S. Food and Drug Administration (FDA). Detection of multiple mycotoxin-producing fungal species is possible through the addition of more LAMP assays for multiplexing specific target genes. Zoom link: https://purdue-edu.zoom.us/j/96550914018?pwd=dDQ1MkY3elArTDNTckM5MGxqdFFpZz0... BME PhD Final Exam Announcement for Emma Vanderlaan, Wed., March 1, 1:00 p.m., MJIS 2001 and via Zoom. Title: Engineering Design of Novel 3D Microphysiological System and Sensor for Functional Assessment of Pancreatic Beta-Cells. Thesis Committee: Dr. Sherry Harbin (advisor), Dr. Carmella Evans-Molina (clinical co-advisor), Dr. Hyowon Lee, Dr. Adrian Buganza Tepole, Dr. Luis Solorio Abstract: Diabetes, a chronic condition characterized by elevated blood glucose levels, arises when pancreatic β-cells lose capacity to produce a robust, dynamic glucose-stimulated insulin secretion (GSIS) response. Accurate measurement of β-cell health and function ex vivo is thus fundamental to diabetes research, including studies evaluating disease mechanisms, novel drug candidates, and replacement β-cell populations. However, present-day dynamic GSIS assays typically represent end-point measurements, involve expensive commercial perifusion machines, and require time-consuming enzyme-linked immunosorbent assays (ELISA) for insulin detection. Microfluidic devices developed as accessible, low-cost alternatives still rely on secondary ELISAs and suspend islets in liquid medium, limiting their survival in vitro. Here, we present a novel, 3D-printed microphysiological system (MPS) designed to recreate components of in-vivo microenvironments through encapsulation in fibrillar type I collagen and restoration of favorable molecular transport conditions. Following computational-informed design and rapid prototyping, the MPS platform sustained collagen-encapsulated mouse islet viability and cytoarchitecture for 5 days and supported in situ measurements of dynamic β-cell function. To rapidly detect insulin secretion from β-cells in the MPS, we then developed a highly sensitive electrochemical sensor for zinc (Zn2+), co-released with insulin, based on glassy carbon electrodes modified with bismuth and indium and coated with Nafion. Finally, we validated sensor detection of Zn2+ released from glucose-stimulated INS-1 β-cells and primary mouse islets, finding high correlation with insulin as measured by standard ELISA. Together, the 3D MPS and Zn2+ sensor developed in this dissertation represent novel platforms for evaluating dynamic β-cell function in a low-cost, user-friendly, and physiologically-relevant manner. Zoom link: https://purdue-edu.zoom.us/j/94439715488?pwd=aElCdCt2VElmUHlMK3ZBQmF6WDZQdz0... Meeting ID: 944 3971 5488, Passcode: 943658 Special BME Seminar, Thurs., March 2, 9:15-10:15 a.m., MJIS 2001. Makito Miyazaki, PhD, Department of Physics at Kyoto University in Japan will present "Reconstitution of Actin Cytoskeletal Dynamics and Functions." This seminar will also be available via Zoom. Abstract: The actin cytoskeleton regulates various key functions of the cell, including division, motility, and polarity establishment. Ultrastructural and molecular biological studies have revealed the nanoscale structures, molecular components, and signaling cascades regulating the actin cytoskeleton step by step. However, it remains unclear how nanometer-sized molecules are self-organized into cell-scale structures and how they cooperate to drive cell functions. To understand the underlying physical principles that govern the cytoskeletal assembly and cell morphogenesis, we employed an in vitro reconstitution approach. We established a method to encapsulate purified proteins or the cytoplasmic extracts of living cells into cell-sized capsules. Using this minimal model of the cell, we are seeking biochemical and physical conditions under which structures and functions recapitulating living cells are self-organized. In this seminar, I will present our recent efforts in understanding the regulatory mechanisms of cell division machinery and motility. Biography: Makito completed doctoral degree at Kyoto University. He did his postdoctoral work with Prof. Shin'ichi Ishiwata at Waseda University reconstituting active cytoskeleton from purified proteins. After working as Assistant Professor at Waseda University, he joined The Hakubi Center for Advanced Research at Kyoto University as a Principal Investigator in October 2017. He started his laboratory aiming to understand the self-organization mechanism of the cytoskeleton and biological functions, using a combination of single-molecule, in vitro reconstitution, and live cell experiments, and theories of physics. He was appointed as Program-Specific Associate Professor at Department of Physics, Kyoto University in October 2022. ~ BME Host: Taeyoon Kim ~ Zoom link: https://purdue-edu.zoom.us/j/93793770670 BME PhD Defense announcement for Nathaniel J. Smith, Fri., March 10, 7:45 a.m., MJIS 2001 and via Zoom. Title of presentation: "Quantitative Modeling of PET Images in the Diagnostic Assessment of Brain and Prostate Cancer." Advisory Committee: Gary D. Hutchins, Co-Chair; Craig J. Goergen, Co-Chair; Lauren Christopher; Sherry L. Harbin; Jason G. Parker Abstract: Positron emission tomography (PET) is a nuclear medicine imaging technique that supports the quantification of physiologic processes within the human body. PET radiotracers are developed with site-specific binding properties or as metabolic analogs, enabling specific tissue properties to be investigated with minimal disturbance to the underlying physiology. Clinically, the radiotracer standard uptake value is a semiquantitative metric that quantifies radiotracer accumulation over a single time interval. However, compartmental modeling of dynamic PET acquisitions provides additional insights into tissue perfusion, binding avidity, and intracellular tracer trapping. Dynamic PET image analysis techniques are first applied to 18F-fluoroethyltyrosine (FET) PET imaging of high-grade glioma and brain metastasis patients. Standard-of-care MRI is often equivocal for discriminating post-treatment imaging aberrations from disease progression. However, temporal 18F-FET efflux (tumor-to-brain ratio slope, intercept) was found to be a highly accurate (95%) metric for identifying cases of disease progression. In a second application, dynamic PET image analysis techniques are applied to 68Ga-PSMA-11 PET imaging for primary prostate cancer patients. In the presurgical planning for prostatectomy, nerve-sparing or nerve-excising surgery is elected based on the dual consideration of metastatic cancer risks and surgically-induced side effects. Even with advanced multiparametric MRI techniques, prostate cancer is often not effectively localized, resulting in over- or under-treatment. Dynamic 68Ga-PSMA-11 PET semiquantitative and kinetic parameters improve the localization of prostate cancer, reducing the prevalence of poor surgical outcomes. Overall, the application of dynamic PET imaging techniques supports improved clinical outcomes and enhanced clinician confidence for treatment modifications. Zoom link: https://iu.zoom.us/j/83716868886 Frontiers in Biophysics Seminar Series, Wed., Apr. 5, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering. Special BME Seminar, Mon., March 27, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Abstract: Abdominal aortic aneurysms (AAA) have a pooled global prevalence of 4.8% and are most common in men 65 years or older. Small AAAs (<4 cm) are commonly asymptomatic and pose little danger, while larger AAAs have a significant risk of fatal rupture that increases with increasing aneurysm diameter. Despite decades of research elucidating the histologic and biochemical features of AAA evolution, clinicians have relatively little capacity to predict or modify AAA progression in practice - we are lacking an understanding of AAA progression on a patient-specific basis, informed by factors readily assessed during periodic imaging-based surveillance. In his talk, Dr Leach will review the current state-of-the-art in clinical AAA evaluation, and present ongoing research on a comprehensive AAA assessment in which aneurysm measurement is augmented by advanced imaging-based measures of aneurysm inflammation, biomechanics, and higher-order morphologic features. Bio: Joseph R Leach, MD PhD is an Assistant Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Leach obtained his PhD in Bioengineering in 2009 from University of California -Berkeley, and completed medical school, residency, and a fellowship in abdominal imaging at UCSF prior to joining the faculty in 2018. Dr. Leach has broad clinical and research interests in vascular disease and applies advanced imaging techniques and imaging-based biomechanical modeling to better understand factors influencing disease initiation, progression, and patient outcomes. Outside of the hospital, Dr. Leach enjoys cooking for his wife, Joyce and their cats Jacks and Nigel, and is a lifelong musician and terrible dancer. ~BME Host: Vitaliy Rayz~ New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 8 3/1/2023 Dr. Joey Wallace Chair and Professor of BME at IUPUI Dr. Young Kim Week 9 3/8/2023 Dr. Hubert Lim Professor, Department of Biomedical Engineering, Otolaryngology, Institute for Translational Neuroscience Scholar, University of Minnesota Dr. Hugh Lee Week 10 3/22/2023 Dr. Daniel DiLorenzo, Assistant Professor, Neurosurgery and Biomedical Sciences, Loma Linda University; Attending Neurosurgeon, Loma Linda VA Medical Center; President Barinetics Corporation Dr. Matthew Ward Week 11 3/29/2023 Dr. Nimmi Ramanujam Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University Dr. Jackie Linnes Week 12 4/5/2023 Dr. Junhong Chen Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory Dr. Chi Hwan Lee Week 13 4/12/2023 Dr. Chien-Chi Lin Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI Dr. Young Kim Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Attachments CDMD RFA 2023.pdf CDMD Application 2023.docx ABRCMS365: Career & Research Summit Peck_flyer -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list