[cid:image001.jpg@01DA3417.4F054AD0] BME WEEKLY ROUNDTABLE END OF SEMESTER December 21, 2023 INTERIM HEAD'S NOTE * Last Sunday, I attended Division II Ceremony of Purdue University's Winter 2023 Commencement. The article on this commencement published in Monday's Purdue Today, stated at the beginning, quote "Years of persistence and thousands of small steps together culminated this weekend for nearly 3,500 Boilermakers as part of Purdue University's Winter 2023 Commencement ceremonies." A significant portion of these Boilermakers are proudly our BME graduates. Congratulations to all the graduating students and their faculty mentors. Thank you to all the faculty who taught them and staff who helped them. I saw Vitaliy and Young there to hood their students. I saw Tami there performing her duty for the college. I want to extend my sincere gratitude to Elsje for performing her duty as the marshal leading the procession of the College of Engineering students on a voluntary basis. A few snapshots that show determination, happiness, and our significant presence at the ceremony. * One of our finest undergraduate students, Nicholas Buffo, gave the student response at the ceremony https://purduenews.exposure.co/2023-winter-commencement/photos/8641587<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduenews.exposure.co%2F2023-winter-commencement%2Fphotos%2F8641587&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133229417%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Ktf8MO8GUQYcDdNTGNr4QvJBagZKUA6ALMiRIc%2BPD4c%3D&reserved=0> * Young and his two PhD students just hooded. https://purduenews.exposure.co/2023-winter-commencement/photos/8641597<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduenews.exposure.co%2F2023-winter-commencement%2Fphotos%2F8641597&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133385684%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6B6Xy5l2JJGyCkVJrNtETI5pOPHtGA3wlBvCmFNDibc%3D&reserved=0> * Last Thursday, I was fortunate to attend our Senior Design Projects Expo and greeted some of the parents who traveled to our campus from as far away as Indonesia. It was a great experience to receive compliments from some of them on how Purdue BME has cultivated their children. I emphasized to them in my welcome speech that today we have planted seeds in each of them; tomorrow, we expect to see many of them grow to be the stars and giants in their professional fields, and we hope they will return their gratitude to us. Pictures from the Expo are attached to this email. Many thanks to Hugh, Asem, and the teaching team for the excellent instruction and advising you did throughout the semester. * I am happy to report to you that Jo Gelfand has been awarded a Bravo+ Award for her extraordinary work done during this past year. I am sure we are very grateful for her hard work and dedication to our School as we go through this critical year that we see many changes and transitions. Thanks to her for completing so many tasks effortlessly and in a timely fashion. I personally benefit greatly from her work on preparing the promotion/tenure dossiers and case presentations. * This has been a challenging semester to me as I try to balance between my administrative duties as the interim head and professional activities as a researcher. In September, the advisory board meeting; in October, the Ascension visit; in November, the promotion/tenure cases; and in December, the offer letters for a set of faculty members and staff coming onboard from IUPUI. With your great help, I think I can give myself an 80 out of 100. There are still many things I can improve upon. I hope to use the opportunities in the spring 2024 semester to better serve you and better represent you, truly as a combination of effective leader, undertaker, and manager. We will have an even more exciting semester in spring 2024. * At the end of this end-of-semester Head's note, I want to wish you and your family a wonderful holiday season. Finally, we all get to relax a little bit and enjoy the company of family members. According to the Chinese zodiac, Year 2024 is the Year of Dragon. Unlike in Western cultures where a dragon is a symbol for evil and darkness, in the Chinese culture, dragons represent good luck, strength, and health. The School, as it continues to grow in its young adult life, clearly shows increasing strength and health. We expect good things come to each of us in the coming year. UPCOMING IMPORTANT DATES Week of December 18 Fri., Dec. 22 - Mon., Jan. 1: Purdue University Winter Recess. All university offices and buildings will be CLOSED. We will reopen for "business as usual" on Tuesday, January 2nd. Virtual Workshop Series on Mastering Grant Writing Tommy Sors, Director of Scientific Strategy and Relations, invites you to elevate your research potential by registering to be part of our exclusive workshop series, meticulously designed to guide you through the competitive landscape of NIH funding and the art of grant writing. Each session builds on the next, so you want to make sure to catch all sessions because they offer the knowledge and tools to craft winning proposals. Sessions ran on Thursdays from 2:00-3:00 p.m. November 30 - December 14 and will continue Tuesdays 10:00-11:00 a.m. January 9-Feb. 13. Register at https://purdue.ca1.qualtrics.com/ife/form/SV_01WMuhATStggQOW<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fife%2Fform%2FSV_01WMuhATStggQOW&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133385684%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=tqUWfFNVP%2BTUrOaVj6s52jr2T3XNPsjatUXRHZ32ijQ%3D&reserved=0> GRADUATE PROGRAM UPDATE Three Minute Thesis Competition Nominate a graduate student to represent your academic unit! The Graduate School's annual Three Minute Thesis competition is scheduled for April 9th! To increase academic representation in our 3MT(r) competition, we are asking that West Lafayette graduate faculty members nominate talented graduate student(s) to represent their academic units. Nominees must be current Purdue graduate students in the final stages of their research. Each nominee will be contacted by Graduate School staff and encouraged to register for the competition. Nominations are not required for students to submit a draft video; they are simply intended to help the Graduate School identify and encouraged talented students to participate. I have shared the link to the nomination form below, as well as some additional information about the Graduate School's 3MT(r) competition. Please email me, Allison Loy (Loy2@purdue.edu<mailto:Loy2@purdue.edu>), with any questions! 3MT(r) 2024 Nomination Form<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_0HW7iBUEZyaGOCa%3F_ga%3D2.197924843.551982344.1700081267-654682909.1700081267&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133385684%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=2iZDcC5hCUFLf4feW77rhMs7zF3cQS%2FgUA0Mu%2Fehzks%3D&reserved=0>: * Nomination Deadline: January 15, 2024 What is 3MT(r)? Three Minute Thesis (3MT(r)) is a research communication competition that helps graduate students develop academic, presentation, and research communication skills so that they can effectively explain their research to a non-specialist audience. During each competition, graduate students will have three minutes to present a compelling discussion on their research topic, including its significance and relevance, to the public. This is a fast-paced competition where the top 10 finalists compete by summarizing their two to three-plus years of research in only three minutes with only one slide. The cash awards for this year's competition are $5,000 for first place, $3,000 for second place, and $2,000 for the People's Choice Award winner. The first-place winner will also be invited to compete in the Midwestern Association of Graduate School's (MAGS) annual 3MT(r) competition. 3MT(r) Timeline * Friday, February 9: Draft Video Submission Deadline - Learn more about making a draft video!<https://www.purdue.edu/gradschool/professional-development/documents/Virtual_3MT_Competitors_Guide.pdf> * Friday, February 16: Semifinalists Announced * Friday, February 23: Semifinals - in person * Monday, February 26: Finalists Announced * Tuesday, April 9: Competition - in person Learn more about the Purdue University Graduate School's 3MT(r) competition at the following URL: https://www.purdue.edu/gradschool/professional-development/competitions/3mt/... Thank you, Allison Loy (s/h) Loy2@purdue.edu Professional Development Events Coordinator Office of Graduate Professional Development The Graduate School Upcoming important deadlines and information Mon., Jan. 8: SLHS Weekly Seminar, 12:30 p.m., LYLE 1160. Soo-Eun Chang, Associate Professor of Psychiatry at the University of Michigan will present "Neurodevelopmental markers of stuttering persistence and recovery." Wed., Jan. 10: BME Distinguished Seminar Series, 9:30 a.m., MRGN 121 (NOTE LOCATION CHANGE) or via zoom. Jason W. Allen, MD, PhD, FACR, Eugene C. Klatte Professor and Chair of Department of Radiology and Imaging Sciences, Indiana University School of Medicine will present "Cryptogenic Strokes Unveiled by Biomedical Engineering Approaches." Mon., Jan. 15: Nomination Deadline for Three Minute Thesis Competition. See full article for details. The actual competition will occur on Tuesday, April 9th. Tues., Jan. 23: Purdue Engineering Distinguished Lecture Series. Yannis C. Yortsos, Dean of Biterbi School of Engineering, Zohrab Kaprielian Dean's Chair in Engineering, University of Southern California will present "The Intertwining of Engineering with Social Phenomena." This seminar is hosted by the College of Engineering, and Davidson School of Chemical Engineering. Register at bit.ly/pedls-yortsos Wed., Feb. 21: Purdue Engineering Distinguished Lecture Series. Russell Allgor, Vice President and Chief Scientist, Worlwide Operations at Amazon.com will present "Logistics and Fulfillment Systems for E-Commerce." This seminar is hosted by the College of Engineering, and School of Industrial Engineering. Register at bit.ly/pedls-allgor Fri., March 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Wed., March 6: Purdue Engineering Distinguished Lecture Series. Karen Willcox, Director, Oden Institute for Computational Engineering and Sciences, Associate Vice President for Research, and Professor of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin will present "From Reduced-Order Modeling to Scientific Machine Learning: How Computational Science is Enabling the Design of Next-Generation Engineering Systems." This seminar is hosted by the College of Engineering, and School of Mechanical Engineering. Register at bit.ly/pedls-willcox Wed., April 10: Purdue Engineering Distinguished Lecture Series. Jeffrey Dean, Google Senior Fellow and SVP of Google Research and Google Health, Google Research will present "Machine Learning, AI and Applications of AI." This seminar is hosted by the College of Engineering, and Elmore Family School of Electrical and Computer Engineering. Register at bit.ly/pedls-dean Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Mon., Jan. 8: SLHS Weekly Seminar, 12:30 p.m., LYLE 1160. Soo-Eun Chang, Associate Professor of Psychiatry at the University of Michigan will present "Neurodevelopmental markers of stuttering persistence and recovery." Abstract: Stuttering is a complex neurodevelopmental disorder affecting 5-8% of preschool-age children, continuing into adulthood in 1% of the population. The neural mechanisms underlying stuttering remain unclear, yet there is accumulating empirical and theoretical support for functional neuroanatomical deficits within the basal ganglia thalamocortical (BGTC) network. There is a dearth of information, however, on possible neurodevelopmental anomalies in stuttering during preschool age, when symptoms typically first emerge. In this presentation, I will discuss recent findings from a longitudinal study of childhood stuttering, in which children with persistent stuttering (pCWS) and those who recovered from stuttering (rCWS) were compared with their fluent age-matched peers, to examine the developmental trajectories of both gray matter volume (GMV) and white matter volume (WMV) during preschool- and school-age years using voxel-based morphometry. A total of 470 MRI scans were analyzed from 95 CWS (72 pCWS and 23 rCWS) and 95 fluent peers between 3-12 years of age. Each participant was scanned up to four times, with an average inter-scan interval of one year. We examined overall group and group by age interactions (growth rate differences) in GMV and WMV in preschool age (3-5 years old) and school age (6-12 years old) children, controlling for sex, IQ, intracranial volume, and socioeconomic status. The results provided broad support for a possible BGTC network deficit starting in the earliest phases of the disorder. Natural recovery from stuttering involved normalization or compensation of earlier occurring structural changes affecting BGTC structures and connectivity among them. I will discuss how these results inform neural bases of stuttering and how earlier occurring differences in neurostructural development may be associated with chronicity of or recovery from stuttering in later years. Future directions will also be discussed, including a research program that seeks to delve into the physiological bases and the temporal dynamics of BGTC function in children who stutter. Bio: Soo-Eun Chang, Ph.D., CCC-SLP, is an Associate Professor of Psychiatry at the University of Michigan. Dr. Chang received her MS degree in Speech and Hearing Sciences at Vanderbilt University, Ph.D. from the University of Illinois at Urbana-Champaign, and postdoctoral training in Clinical Neurosciences at the National Institutes of Health (NINDS/NIH). Dr. Chang's research combines multimodal neuroimaging and behavioral experiments to examine the neural bases of stuttering persistence and recovery. Wed., Jan. 10: BME Distinguished Seminar Series, 9:30 a.m., MRGN 121 (NOTE LOCATION CHANGE) or via zoom. Jason W. Allen, MD, PhD, FACR, Eugene C. Klatte Professor and Chair of Department of Radiology and Imaging Sciences, Indiana University School of Medicine will present "Cryptogenic Strokes Unveiled by Biomedical Engineering Approaches." Abstract: Internal carotid artery webs (CaW) are a relatively common, but frequently overlooked etiology of cryptogenic strokes, particularly in younger patients. CaW are not related to atherosclerosis, and instead demonstrate atypical fibromuscular dysplasia on histopathology. These lesions appear as shelf-like or pyramidal-shaped projections and occur exclusively in the bulbar segment of the internal carotid artery. Despite generally producing <50% stenosis of the lumen, CaW are thrombogenic and are resistant to standard antiplatelet monotherapy, unlike atherosclerotic plaques associated with a similar degree of luminal narrowing, which are usually asymptomatic. Furthermore, the composition of CaW-associated emboli likely differs from other arterial clots and appears similar to venous clots, suggesting a different mechanism of thrombogenesis. Using a multimodal approach of 4D flow MRI and computational fluid dynamics simulations, we have shown that immediately downstream of CaW, there is increased stagnation with larger areas of the vessel wall exposed to decreased wall shear stress and increased oscillatory index. These persist throughout the cardiac cycle and likely set the stage for thrombosis and subsequent stroke. We have also demonstrated that CaW are amendable to carotid stenting, providing a less invasive treatment option to carotid endarterectomy. As the prevalence of CaW in the general US population is 1-7%, understanding the mechanism of thrombogenesis and the future and recurrent stroke risk in these patients is critical to determining appropriate, patient-centric clinical care. Biography: Jason W. Allen, MD, PhD, FACR is the Eugene C. Klatte Professor and Chair of the Department of Radiology and Imaging Sciences at the Indiana University School of Medicine. Dr. Allen obtained his MD and PhD in Neuroscience from Georgetown University School of Medicine and completed residencies in Neurology and Diagnostic Radiology as well as a two-year Neuroradiology fellowship at New York University School of Medicine. He previously was a partner at TRA Medical Imaging in Washington as well as a prior Professor at Emory University School of Medicine where he served in several roles, including the Neuroradiology Division Director, Medical Director of the Emory Center for Systems Imaging Core (CSIC), and Director of the Laboratory for Imaging Neuroscience at Emory (LINE). His primary research interests are characterizing the alterations in advanced neuroimaging metrics in the setting of neuronal injury, including stroke, traumatic brain injury, and neurodegenerative disorders, as well as the diagnosis and prognosis of cerebrovascular disease, such as subarachnoid hemorrhage, cerebrovascular reserve, and internal carotid webs. His laboratory is funded through several federal, private foundation, and institutional grants. He is also active in national organizations, particularly the American Society of Functional Neuroradiology (ASFNR) and the American Society of Neuroradiology (ASNR). ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F5593290378%3Fpwd%3DeFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133385684%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=%2F%2FI82YMMdRLXvKkA8ty9mHmdT0R3%2FMVpb3Q3f96ez4c%3D&reserved=0> Note: Students registered for the seminar are expected to attend in-person. Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C2af106f853df467dc3bd08dc02587423%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638387826133385684%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=k1DR27y3rrT3rufrgldn8NSZuxQPoDSdMvTneWseVl4%3D&reserved=0> -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list