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BME Seminar Monday, March 9, 2026 2:00 – 3:00 pm, MJIS 2001 Microsoft Teams meeting Join: https://teams.microsoft.com/meet/29576486050725?p=8x7wzEiwd7p8GmY4WA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2Fmeet%2F29576486050725%3Fp%3D8x7wzEiwd7p8GmY4WA&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639718699676%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=M5gQ7Q1SBLF08BarEjmV3ALXikmWtReuu9iTugk5ols%3D&reserved=0> Meeting ID: 295 764 860 507 25 Passcode: XW9iM6sh “Generative AI for 3D Reconstruction in Cryo-Electron Microscopy” [cid:image001.jpg@01DCAFB0.3F50FF50] Yilai Li, PhD Research Scientist, ByteDance Seed, AI-for-Science Abstract: Single-particle cryo-electron microscopy (cryo-EM) determines 3D biomolecular structure by computationally reconstructing it from extremely noisy experimental 2D projections of individual particles with unknown orientations. In real datasets, reconstructions are often limited by dataset-specific corruptions such as anisotropy from uneven viewing angles or spatially varying signal-to-noise ratios; more fundamentally, cryo-EM 3D reconstruction is an ill-posed inverse problem that benefits from informative priors. In this talk, I will introduce cryoFM, a generative foundation model trained on large collections of experimental electron density maps, and serves as a Bayesian prior for cryo-EM 3D reconstruction. By pairing this learned prior with different explicit measurement models, we use posterior sampling to address a range of reconstruction and map-improvement tasks. I will highlight representative examples where our approach improves cryo-EM 3D reconstruction under challenging conditions, and conclude with broader directions for extending generative priors and inference beyond the current reconstruction setting. Bio: Dr. Yilai Li is a Research Scientist at ByteDance Seed developing AI/ML methods for cryo-electron microscopy (cryo-EM) reconstruction. He received his Ph.D. in Biophysics and completed postdoctoral training at the University of Michigan, where he worked on computational and automated methods for cryo-EM data acquisition and processing. His research focuses on combining modern AI with principled modeling to make cryo-EM analysis more accurate, robust, and accessible. ________________________________________________________________________________ Microsoft Teams meeting Join: https://teams.microsoft.com/meet/29576486050725?p=8x7wzEiwd7p8GmY4WA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2Fmeet%2F29576486050725%3Fp%3D8x7wzEiwd7p8GmY4WA&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639718840518%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=3pnZVRDLeF5OJdPdHm2QDZzGRocanLb4mzTnYw7duoo%3D&reserved=0> Meeting ID: 295 764 860 507 25 Passcode: XW9iM6sh ________________________________ Need help?<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Faka.ms%2FJoinTeamsMeeting%3Fomkt%3Den-US&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639718921169%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=N6Nj7HGWarppF7moZ5EnvWeItf6Lhg3a7Q1QwD4IJio%3D&reserved=0> | System reference<https://teams.microsoft.com/l/meetup-join/19%3ameeting_YWEyZWFjN2YtZGZhNy00OWUyLTk4MjgtYmZiMmJhY2ZkZGUy%40thread.v2/0?context=%7b%22Tid%22%3a%224130bd39-7c53-419c-b1e5-8758d6d63f21%22%2c%22Oid%22%3a%22df347d6f-ac43-4e29-a82a-129a7532453a%22%7d> Dial in by phone +1 219-293-4410,,50899930#<tel:+12192934410,,50899930> United States, Gary Find a local number<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdialin.teams.microsoft.com%2Fe6a15c08-dda2-4f4f-8bb1-75d00bf33d17%3Fid%3D50899930&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639718992852%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=%2FyNcnEKCqTzz9JeypzQjtGIgDu9GO6Km5FJfgGoo28E%3D&reserved=0> Phone conference ID: 508 999 30# Join on a video conferencing device Tenant key: purdue@m.webex.com<mailto:purdue@m.webex.com> Video ID: 119 610 093 5 More info<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.webex.com%2Fmsteams%3Fconfid%3D1196100935%26tenantkey%3Dpurdue%26domain%3Dm.webex.com&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639719070366%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=NFoAkEczuPhvoo8uY%2BgACzHZLS9g5kVE8eFfi7eOmpI%3D&reserved=0> For organizers: Meeting options<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2FmeetingOptions%2F%3ForganizerId%3Ddf347d6f-ac43-4e29-a82a-129a7532453a%26tenantId%3D4130bd39-7c53-419c-b1e5-8758d6d63f21%26threadId%3D19_meeting_YWEyZWFjN2YtZGZhNy00OWUyLTk4MjgtYmZiMmJhY2ZkZGUy%40thread.v2%26messageId%3D0%26language%3Den-US&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639719138878%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=%2Fw2ZyvSDxLaUuEf%2FMGRnSkZk7lJUkb6HY9QIn9OfzSo%3D&reserved=0> | Reset dial-in PIN<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdialin.teams.microsoft.com%2Fusp%2Fpstnconferencing&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7C899fa35b72f8487f68e308de7de99cae%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639719174190%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=8gbtLNRzmNB8jSki6CnAKviOHNY92sRMlruNx16OK6c%3D&reserved=0> ________________________________________________________________________________