BME Master's Defense Announcement for Caitlin Savage (Y. Tong, advisor) Everyone is invited to attend the public presentation beginning at 3:00 pm. Title: Multimodal neuroimaging of olfactory processing: the design and development of a novel approach for clinical applications. Date: April 16 Time: 3:00pm Location: MJIS 2001 or Zoom - https://purdue-edu.zoom.us/j/9894222494<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F9894222494&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7Ce8b0901b3622433bcb9108dd7b67d441%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638802408039827468%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=FPD1NANT%2BARnXAO1R2DbIBKC2WN1h9bgacoAFb6DIJQ%3D&reserved=0> Meeting ID: 989 422 2494 Committee: Dr. Yunjie Tong, Dr. Vijay Ramakrishnan, Dr. Maria Dadarlat Abstract: The olfactory system plays critical roles in health, safety, emotion, memory, and social bonding behaviors, and serves as an important window into central nervous system health. Approximately 20% of the population is reported to experience some type of olfactory dysfunction, such as hyposmia, anosmia or dysosmia. However, due to the highly subjective and complex quality of this sense, olfactory dysfunction often goes undiagnosed in patients, leading to detriments in quality of life as well as the possible overlook of neurological conditions. Existing clinical diagnostic tests lack sensitivity and specificity. While neuroimaging approaches such as functional magnetic resonance imaging (fMRI) can characterize olfactory processing, they tend to be used only in research settings due to being time consuming and costly. Functional near-infrared spectroscopy (fNIRS) is a low-cost, non-invasive method of measuring hemodynamic responses related to brain activity by passing infrared light between optodes on the surface of the scalp; however, it is limited to imaging cortical regions due to noise sensitivity and low penetration depth, which heavily impede its ability to image deeper structures such as the olfactory bulb. The goal of the project outlined here is to design and test a NIRS-coupled nasal endoscope for clinical use to achieve closer proximity to the olfactory epithelium and bulb, for an objective understanding of the patient's olfactory processing. Traditional external fNIRS and fMRI are performed to establish baseline activation patterns and better understand the current limitations in imaging of the olfactory system. Future work will include engineering, validating and clinically testing the NIRS-coupled nasal endoscope to improve diagnostic precision of olfactory dysfunction. -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list