IBSC-BME Preliminary Exam Announcement for Antonia Susnjar (J Rispoli and T. Talavage, advisor) Everyone is invited to attend the public presentation beginning at 10:00 AM. Title: Clinical Applications of Innovative Magnetic Resonance Techniques Date: April 21, 2022 Time: 10:00 AM EST Location: MJIS 2001 or Link: https://purdue-edu.zoom.us/j/99417184999 Advisory committee: Joseph V. Rispoli, co-chair; Thomas M. Talavage, co-chair; Ulrike Dydak; Uzay Emir Abstract: Magnetic resonance imaging (MRI) has undergone an enormous advancement in diagnostic accuracy through improved comprehensive evaluation of early soft tissue transformation while avoiding the exposure to potentially dangerous ionizing radiation. With decreased cost and enhanced availability, the use of MRI is becoming ever more persuasive throughout clinical practice. Complementary to the MRI, magnetic resonance spectroscopy (MRS) offers unique information about the micromolecular composition of the human body by capturing the chemical signature of metabolites and neurotransmitters via frequency changes and displaying this information in a spectrum. The applications of MRS to investigate the metabolic window on a wide range of biochemical processes are incredibly diverse. For example, we have utilized MRS to investigate the composition and function of the human brain in post-traumatic stress disorder, traumatic brain injury, addiction, and hyperbaric oxygen therapy assessment. In addition to MRS biological specificity, diffusion tensor imaging (DTI) is yet another advanced MRI methodology used to map and characterize the three-dimensional diffusion of water as a function of spatial location. Analogous to the MRS, DTI applications are diverse and not limited to in vivo studies. To address the significant challenges of strict drug user adherence regimens for numerous treatments, we have evaluated the drug release profile from a newly developed in situ forming implants (ISFIs) for sustained and constant drug delivery. Taken together, advanced MRI methods that probe the morphology, microstructure, function, and chemical changes are clinically applicable in various diseases and conditions.