[cid:image003.jpg@01D97753.6205ABB0] BME MONDAY ROUNDTABLE APRIL 24, 2023 (Start of purdue's quiet period) DEPUTY HEAD'S NOTE * This week is Purdue's quiet period. For more information, please see the first item in the Upcoming Important Dates section. This is indeed the time of year we are all stressed by the deadlines. As the image above, stay calm, be positive, and take it easy. * I want to use this opportunity to remind you of this summer's Trailblazers in Engineering workshop. It will be held on the Purdue campus July 25-26, 2023. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Dear PhD students who will be on job market in the coming fall or who graduated recently, I encourage you to apply. Dear faculty, please encourage your students to apply. The application submission deadline is May 25th, 2023. For more information, please see the message in the Upcoming important deadlines and info section. * The 2023 Purdue College of Engineering Design Expo will be held this Thursday from 10 - 2 pm at Purdue Armory. As far as I know, two BME senior design teams will showcase their engineering design and participate in design challenges. For more information, please see the message in the Upcoming Important Dates section. * The Weldon End-of-Year Celebration, featuring the Awards & Scholarship Ceremony will be held this Friday afternoon. Dear faculty, please come out to recognize our students' contributions and celebrate their accomplishments in the past year. At least, I consider this as a de-stress event for our students. * Six Purdue University PhD students from Biomedical Engineering and Industrial Engineering will be participating in the revamped Bottorff Fellows program for the 2023-2024 school year. This includes two months of in-depth clinical immersion over the summer, followed by courses on technology translation and work with an industry or clinical mentor that will help fellows consider best approaches for moving their work from bench to bedside. This yearly program is funded by the Purdue College of Engineering in close collaboration with the Indiana University School of Medicine and named after Leslie Bottorff<https://www.linkedin.com/in/lesliebottorff/>. * Finally, dear faculty, starting this week, I will have one-on-one meetings with you. I look forward to having the chance to chat about various things with you. Important MJIS Alert Starting Monday, May 22nd, Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details. UPCOMING IMPORTANT DATES Week of April 24 Mon., April 24 - Fri., Apr. 28: Purdue University Quiet Period. "Quiet Period" is defined as a time during which courses that conduct or collect an assessment during the final exam period shall refrain from assigning or collecting assessments. Here, "assessments" are defined as activities relating to the course's learning objectives that students turn in for class credit that the course instructor intends to use to judge whether students have met the associated learning objectives. Assessments do not include class participation during normally-scheduled class time. Courses that do not offer an assessment (such as a final exam, quiz) during the final examination period are exempt from following the restrictions on Quiet Period. It is the responsibility of the unit head to ensure that the unit's faculty preserves this regulation thusly. Mon., April 24, Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 p.m., R4 101 (Indianapolis) and via Zoom. Olha Melnyk, PhD, Postdoctoral Fellow, Linnemann Lab, Herman B. Wells Center for Pediatric Research, Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, will present "Real-time in vivo imaging of the islet autophagy." Zoom link: https://iu.zoom.us/s/87501979533 Tues., Apr. 25, Biological Sciences Seminar Series, 12:00 p.m., Pfendler Hall, Room 241. Dr. Satyajit Mayor, National Centre for Biological Science, TIFR, Bangalore, India, will present "The eukaryotic cell membrane: An integrator of mechanical and chemical inputs." Tues., Apr. 25-Thurs., Apr. 27: Artificial Intelligence in Healthcare Innovation: Moving from Reactive to Proactive Conference hosted by the Regenstrief Institute and Indiana University School of Medicine, Department of Biostatistics & Health Data Science, April 25-27. Registration is free, and available at regenstrief.org/ai-conference-2023 Wed., April 26: Purdue Day of Giving (PDOG), This April 26 is more than just another day - it's a day to note the incredible impact of 10 years of giving back, 10 years of paying it forward, 10 years of opportunities granted, and 10 years of making giant leaps for Purdue! Join Purdue alumni and students, friends and family, faculty, staff, retirees, and fans from West Lafayette, across the country, and around the globe, as we come together to celebrate the 10th annual Purdue Day of Giving - and be part of Purdue's next giant leap! And best of all, FREE DONUTS from 9-10:30 a.m. in the MJIS Atrum! Wed., April 26: Weldon BME Distinguished Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Dr. James Moon, J.G. Searle Professor of Pharmaceutical Sciences, Biomedical Engineering and Chemical Engineering at University of Michigan will present "Engineering strategies to modulate the gut microbiome and immune system." Wed., April 26: BRAG Session, 11:45 a.m. to 12:45 p.m., MJIS 2001. We cordially invite you to our upcoming BRAG session featuring Prof. Jacqueline Linnes, the Marta E. Gross Associate Professor of Biomedical Engineering and Director of College of Engineering Honors Program at Purdue University. During this session, Prof. Linnes will be sharing invaluable insights in her talk titled, "What I didn't know about finding a job until I was the one hiring: what you should do in your own job hunt." Mark your calendars for Wednesday, April 26th, from 11:45 am to 12:45 pm, and join us in MJIS 2001 for a productive lunch session. If you have any dietary restrictions, please let us know in advance. Please RSVP to the Outlook invitation directly to us (Moniusha Elumalai - melumala@purdue.edu). We welcome all attendees and encourage you to bring a Postdoc/Visiting scholar/Research engineer friend along with you!!!! Thurs., Apr. 27: Purdue Computational Imaging Seminar, 10:00 a.m., Fowler Hall. Dr. Joseph M. Howard, NASA, will present "Current and Future NASA Space Telescopes." Free admission, but registration required: https://forms.gle/NtLyFzVPbrUAY8uM8 Thurs., Apr. 27: Seminars in Hearing Research, 10:30 a.m., LYLE 1150 and via Zoom. Julie Cohen, Au.D., PhD, Scientific Reviewer/Audiologist, Food and Drug Administration will present "Over-the-Counter (OTC) hearing aid regulation by the FDA. Zoom link: https://purdu-edu.zoom.us/j/4326340458 Meeting ID: 432 634 0458 Fri., Apr. 28: Institute for Control, Optimization and Networks (ICON) Weekly Seminar, 3:30-4:45 p.m., ARMS 1109 and via Zoom. Nan Kong presents "Shortening Emergency Medical Response Time with Unmanned Aerial Vehicle-Ambulance Joint Operations." Upcoming important deadlines and info. Mon., May 8: BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Wed., May 10: BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Fri., May 12: Diabetes Data and Hypothesis Hub (D2H2) Seminar, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Academic Programs Update Fall 2023 Course Schedule is attached to this email. If you are interested in nominating an Undergraduate Teaching Assistant (UGTA) for the 2023-24 academic year, please do so using the link below: https://purdue.ca1.qualtrics.com/jfe/form/SV_9ynOH9kOdtPsWmq Please submit the survey by May 1st for consideration. If you have any questions, you can reach out to Asem Aboelzahab (aboelzahab@purdue.edu<mailto:aboelzahab@purdue.edu>). If you have graduate students in your lab who may be interested in serving as a TA for the coming school year, we need your nominations (including their additional background information) by May 1st, 2023. If your student has a fellowship for the upcoming academic year, we ask that you please refrain from nominating them at this time. In the Weldon School we do our best to distribute teaching assignments to the students who are the best fit for each course. Therefore, if you have any graduate students (residents or international) who you would like to be considered for a TA appointment in the 2023-2024 year, please complete the following survey with the required information for determining best fit: https://purdue.ca1.qualtrics.com/jfe/form/SV_7WjqEDEX5RVlk7Y A description of courses is attached for your reference. If you are nominating an international student who has not taken the Oral English Proficiency Test (OEPT), please contact Asem Aboelzahab aboelzahab@purdue.edu<mailto:aboelzahab@purdue.edu>) to schedule your student for the test ASAP. Note that preference will be given to students in the graduate programs of the Weldon School. · Drop-in virtual help sessions can assist faculty with end-of-semester Brightspace, other instructional technology - Purdue University Online - Purdue University<https://discover.online.purdue.edu/news/2023/04/05%20-%20Drop-in%20virtual%20help%20sessions%20can%20assist%20faculty%20with%20end-of-semester%20Brightspace,%20other%20instructional%20technology.php?image> Full Term (16 Weeks) and Second Eight-Week Session grade entry (meeting between March 6 and May 6) begins at 8 a.m. April 21 and ends promptly at 5 p.m. May 9. 1. Now is the perfect time for faculty to take the 15 minutes to get all their required certifications up to date BEFORE the deadline approaches. * FERPA * GLBA * Data Handling * Protecting SSNs 2. This page<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html> provides myPurdue grade entry instructions. 3. This page<https://www.purdue.edu/brightspace/Docs/Grades/SubmitFinalGradesToBanner.php> provides BrightSpace final grade submission instructions. 4. Those not making the deadline can use the Grade Change Workflow. * Instructions may be found here<https://www.purdue.edu/registrar/faculty/grading/Grade_Change_Workflow.html>. 5. Lastly but still very important, any faculty that assigned an Incomplete in Spring 2022 has until Tuesday, May 5 at 5pm to use the Grade Change Workflow to submit a completion grade. If not submitted by this deadline it will revert to an IF grade for the student. * Any extension requests for students that faced obstacles outside of their control should be submitted to @Shomaker, Lori<mailto:lshomake@purdue.edu> no later than Friday, May 5 for processing. Graduate Office Update Dear BME Faculty, Weldon BME PhD students performing research in one of these areas - cardiovascular devices, implantable biomaterials design, drug-delivery systems, or biochemical sensors - are eligible for nomination for the Ronald W. Dollens Scholarship. For the nomination, we will need from you a short description (less than 250 words) of an outstanding, current graduate student in your lab who is excelling in research performance and service to the department. In your description, please mention/include the following: * Student's year in the PhD program (1st year, 2nd year, etc.) * Brief description of outstanding research performance * Brief description of service to the department * Mention of recent awards, presentations made at conferences, papers authored, etc., that you think help describe the student's contributions * Student's CV Please send the nomination to tsiemers@purdue.edu<mailto:tsiemers@purdue.edu> by Sunday, May 21st. The Ronald W. Dollens Scholarships in Life Sciences will be awarded based on academic merit to two deserving graduate students in the Weldon School of Biomedical Engineering who meet the criteria and are selected. The scholarship award is $5,000 with half being awarded in the Fall 2023 semester and half in the Spring 2024 semester. If you have any questions, please don't hesitate to reach out. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. Research Update To safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and "hidden" predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned. https://www.science.org/content/article/fast-growing-open-access-journals-st... https://retractionwatch.com/2023/03/21/nearly-20-hindawi-journals-delisted-f... Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information Biological Sciences Seminar Series, Tues., Apr. 25, 12:00 p.m., Pfendler Hall, Room 241. Dr. Satyajit Mayor, National Centre for Biological Science, TIFR, Bangalore, India, will present "The eukaryotic cell membrane: An integrator of mechanical and chemical inputs." Abstract: The surface of a eukaryotic cell interfaces with the external milieu constantly, decoding signals in the form of chemical and mechanical inputs. These cues which are interpreted primarily by membrane receptors which are embedded in the plasma membrane, a fluid lipid bilayer templated by an active cortical actin meshwork. One such membrane receptor, the integrin receptor binds to the extracellular matrix, and receives mechanical signals from the external environment. Chemical cues activate Rho A-dependent signaling cascades in the cell, whereas mechanical inputs activate mechano-transducers via the Talin-Vinculin axis. Remarkably, integrin receptor activation downstream of these two pathways leaves an imprint on this fluid membrane in the form of spatially localized mesoscale liquid-ordered (lo) membrane domains resembling active emulsions. These membrane domains encode information about both the chemical and mechanical nature of the substrate. This is necessary for integrin receptor function, namely cell spreading and migration in complex environments. The active actin-membrane composite thus behaves as a mechano-responsive medium, integrating chemical and physical cues for the regulation of cell physiology. This seminar is sponsored by the Purdue Department of Biological Sciences and PI4D. Weldon BME Distinguished Seminar, Wed., April 26, 9:30 a.m., MJIS 1001 and via Zoom. Dr. James Moon, J.G. Searle Professor of Pharmaceutical Sciences, Biomedical Engineering and Chemical Engineering at University of Michigan will present "Engineering strategies to modulate the gut microbiome and immune system." Abstract: New approaches are needed to improve immunotherapies with minimal immune-related adverse events. The gut microbiome has recently emerged as the next frontier in drug development; however, it remains unclear how to effectively alter gut microbiota for treating various diseases, including cancer. Here, we present new biomaterial-based strategies for altering the gut microbiome and improving the safety and efficacy of cancer immunotherapy. We are developing new dietary fiber-based biomaterials for in situ modulation of the gut microbiome for augmenting local and systemic immune responses. Oral administration of inulin-gel in tumor-bearing mice in combination with anti-PD-1 immune checkpoint blockade led to robust anti-tumor efficacy while mitigating immune-related adverse events. In our second research thrust, we are developing a new nanoparticle platform for systemic delivery of STING (stimulator of IFN genes) agonists. While local STING activation can convert cold tumor into hot tumor, it has been challenging to develop STING agonists that can treat disseminated cancer due to their toxicity. Here, we will present our data showing that addition of manganese to STING agonists results in robust synergy. Lipid-based nanoparticles containing manganese and STING agonists allows for systemic cancer immunotherapy with potent efficacy, favorable pharmaceutical properties, and acceptable safety profiles in various murine and rabbit tumor models. Our biomaterial-based strategies may offer powerful and convenient approaches to regulate the immune system as potential therapies for cancer and other diseases. Biography: Dr. James Moon is John Gideon Searle Professor in the Department of Pharmaceutical Sciences, Biomedical Engineering, and Chemical Engineering at the University of Michigan, Ann Arbor. His interdisciplinary research program aims to develop novel biomaterials-based strategies to advance fundamental understanding of the immune system, with the ultimate goal of improving patients' lives with effective vaccines and immunotherapies. Dr. Moon has published over 110 research articles, including those published in Nature Materials, Nature Medicine, Nature Nanotechnology, Nature Biomedical Engineering, Nature Reviews Materials, and Science Translational Medicine. He has over 20 pending/approved U.S. and international patent applications, and his novel nano-vaccine delivery technologies have led to 3 new start-up companies (EVOQ Therapeutics, Saros Therapeutics, and Elicio Therapeutics). Dr. Moon is a fellow of BMES and AIBME, and his contributions to the field has been recognized with numerous awards, including NSF CAREER Award. Dr. Moon received his bachelor's degree from the University of California, Berkeley, and his Ph.D. from Rice University, and he completed his postdoctoral training at MIT. ~ BME Host: Chi Hwan Lee ~ NOTE: Students registered for the seminar are expected to attend in-person. Zoom link: https://purdue-edu.zoom.us/my/chihwanlee Purdue Computational Imaging Seminar, Thurs., Apr. 27, 10:00 a.m., Fowler Hall. Dr. Joseph M. Howard, NASA, will present "Current and Future NASA Space Telescopes." Free admission, but registration required: https://forms.gle/NtLyFzVPbrUAY8uM8 Abstract: Astronomy is arguably in a golden age, where current and future NASA space telescopes are expected to contribute to this rapid growth in understanding of our universe. A summary of our current space assets will be given, including the James Webb Space Telescope (JWST), our most recent addition. Future telescopes will also be discussed, including the Nancy Grace Roman Space Telescope (RST), the Laser Interferometer Space Antenna (LISA), as well as mission concept studies being prioritized in the 2020 Decadal Survey in Astrophysics. Bio: Joseph M. Howard received BS in physics from the US Naval Academy in Annapolis, Maryland, and his Ph.D. in Optical Design from The Institute of Optics, University of Rochester, in Rochester, NewYork. He now serves as an optical designer for NASA, working on projects including the James Webb Space Telescope, the Roman Space Telescope, LISA, and other future space missions. Joe lives with his wife, two children, and dog and cat in Washington DC. Event Inquiry: Professor Stanley Chan (stanchan@purdue.edu) Institute for Control, Optimization and Networks (ICON) Weekly Seminar, Fri., Apr. 28, 3:30 p.m., ARMS 1109 and via Zoom. Nan Kong presents "Shortening Emergency Medical Response Time with Unmanned Aerial Vehicle-Ambulance Joint Operations." Abstract: Unmanned aerial vehicles (UAVs) can improve emergency medical service (EMS) logistics by quickly delivering medical interventions with the help of bystanders. We formulate a Markov decision process to jointly optimize the dispatching and redeployment of UAVs and ambulances in real-time. To tackle the curse of dimensionality, we adopt an approximate dynamic programming approach with neural network-based value function approximations. Our approach outperforms existing benchmarks and provides guidance for effectively incorporating UAVs into EMS operations. By highlighting the potential advantages of using UAVs, we hope to encourage their wider adoption in EMS practice. Following the above focused technical talk, I will talk about more recent research developments in my lab, including (1) supervised learning based recommendation module for smart dispatch system; and (2) UAV-bystander teaming at the scene of emergency response. Bio: Nan Kong is Professor and Deputy Head of the Weldon School of Biomedical Engineering at Purdue University. He is also Associate Director for Health Systems at the Purdue's Regenstrief Center for Healthcare Engineering. He graduated with a B.S. degree in Automation from Tsinghua University, China, in 1999 and a Ph.D. degree in Industrial Engineering from the University of Pittsburgh in 2006. He joined the BME faculty at Purdue in August 2007 and has developed an active research program in the areas of healthcare analytics and systems optimization. He has been funded as Principle Investigator by grants from NSF, NIH, and Air Force with several other co-Investigator grants from CMS and AHRQ. He is an active member of INFORMS and IISE. Zoom link: https://purdue-edu.zoom.us/j/99326083199?pwd=TjhqaE1TYkZ2RG1RMkt6S1JZbGk1UT0... Free coffee and snacks will be provided. BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), Mon., May 8, 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Committee Members: Doug Brubaker, Ph.D. (Chair), Elizabeth Proctor, Ph.D., Deva Chan, Ph.D., Tamara Kinzer-Ursem, Ph.D., Brendan Lucey, M.D. Abstract: Alzheimer's disease (AD) is the most common form of dementia and is often presented with aggregates of amyloid-β and intracellular tau proteins in the brain, which leads to downstream progressive memory loss and cognitive impairment. Multiple risk factors for AD development include age, genetics, and other pre-existing diseases such as type 2 diabetes (T2D). While up to 81% of people with AD may have T2D or impaired glucose levels, the biological mechanisms by which T2D exacerbates AD pathology are not well-understood. Previous studies shown that orexin, a neuropeptide responsible for appetite, arousal, and wakefulness, to be involved in AD and T2D pathology, which may be a potential link between the two diseases. We propose that protein aggregation in the brain, and metabolic processes regulated by the orexin network and T2D exacerbates AD pathology. To test this idea, we will first identify functional and biological associations of gene expressions via protein interaction networks and gene set enrichment analysis. Second, we will incorporate publicly available mouse, post-mortem human brain tissue, and human cell line transcriptomic data into our computational model to characterize pathways by which proteinopathy, T2D and orexin are predictive of human neuropathological status. Finally, we will quantify neuroinflammatory cytokines and gene expression by performing multiplexing assays and RNA sequencing of primary neuron samples after stimulation with disease-associated metabolites and orexin antagonist. Upon completion of this study, we will have improved our understanding on biological mechanisms in which orexin and T2D exacerbates AD pathology, which may introduce avenues for disease-directed therapeutics. Zoom Link: https://purdue-edu.zoom.us/j/5554725555 BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), Wed., May 10, 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Committee: Hyowon Lee, Chair; Aaron B. Bowman; Chi Hwan Lee; Jacqueline Linnes Abstract: Electrochemical biosensor arrays been integrated into microfluidic cell culture platforms have measured metabolic markers, proteins, and nucleic acids. There is a gap for electrochemical biosensor lab on a chip for simultaneously monitoring multiple neurotransmitters, such as glutamate and dopamine, while compatible with recombinant fluorescent neurotransmitter and epigenetic biosensors. A microfluidic neuronal cell-culture platform with these capabilities would be a valuable tool for quantifying phenotypes of PD-linked epigenetic change resulting from environmental chemical exposure. To this end, we aim to develop arrays of enzymatic electrochemical sensors for multi-analyte biosensing. We have developed sensors using direct ink writing robotic printing and conventional thin film processing that can simultaneously measure neurotransmitters (glutamate) and metabolic biomarkers (glucose and lactate) together simultaneously in cell culture media. We have also shown the biocompatibility of theses sensors for neuronal cell culture. What remains to do is verify their stability during many weeks exposure to cell culture conditions and to demonstrate glutamate measurement from glutaminergic neurons in a microfluidic chip. Diabetes Data and Hypothesis Hub (D2H2) Seminar, Fri., May 12, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Abstract: This seminar will discuss two new interactive bioinformatics software tools that integrate knowledge from many NIH funded and other key resources for hypothesis generation. The Diabetes Data and Hypothesis Hub (D2H2) is a platform that integrates tools and datasets related to diabetes research into one integrative platform. The Playbook Partnership Workflow Builder (PPWB) is a system that enables novice users to created bioinformatics workflows by exploring a network of distributed but connect microservices. These two new tools will be demonstrated through a variety of use cases with applications that prioritize personalized drugs and targets for kidney disease, diabetes, and pan-cancer. Bio: Dr. Ma'ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences, Director of the Mount Sinai Center for Bioinformatics, and a faculty member of the Department of Artificial Intelligence and Human Health at the Icahn School of Medicine at Mount Sinai in New York City. The Ma'ayan Laboratory applies computational methods to study the complexity of regulatory networks in mammalian cells. His research team develops software systems to help experimental biologists form novel hypotheses from high-throughput data with a focus on drug and target discovery through machine learning and other statistical methods. Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha@purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Attachments BME Course Descriptions 2023ClimateSurveyFlyer_Emailing.pdf Course List Fall 2023 PDOG23-MJIS -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list