BME MONDAY ROUNDTABLE

FEBRUARY 20, 2023

 

DEPUTY HEAD’S NOTE

 

UPCOMING IMPORTANT DATES

 

Week of February 20

Mon., Feb. 20: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon, via Zoom. Misty Hawkins, PhD, Associate Professor of Health & Wellness Design, School of Public Health Indiana University Bloomington will present “Executive Function and Behavioral Weigh Loss: The Missing Moderator of Cardiometabolic Health Interventions?” Zoom link: https://iu.zoom.us/s/87501979533

Wed., Feb. 22: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Rita Patel, PhD, CCC-SLP, Associate Professor and Speech Language Pathologist, Department of Otolaryngology, Head and Neck Surgery, Indiana University School of Medicine, will present “An interdisciplinary scientific journey.”

Wed., Feb. 22: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. Dr. Jimmy Dooley, Assistant Professor of Biological Sciences at Purdue will present “How movements during sleep teach infant brains how their bodies move.”

Thurs., Feb. 23:  RCHE Graduate Student Seminar Series, 3:00-4:00 p.m., via Microsoft Teams. Presenters include Geonsik Yu (PhD student in Industrial Engineering) and Alexis Hoerter (PhD student in Biomedical Engineering).

Fri., Feb. 24: Faculty Info Session and Roundtable on U.S. Fulbright Faculty Award Program, 3:30-4:30 p.m., WALC 3138, sponsored by the Office of the Provost. The session will be led by Chris Lukasik, provost’s fellow for Fulbright faculty awards, and will be followed by a Q&A. “Purdue continues to be a top-producing institution for the Fulbright Scholar Program,” Lukasik says. “Over half of all Purdue faculty applicants for the Fulbright Scholar award program end up winning.” Faculty interested in developing or expanding their international profile will learn more about the two types of Fulbright awards programs: 1) Fulbright Scholar Award and 2) Fulbright Specialist Award. Lukasik says that attendees will have their questions answered and some misconceptions clarified. While the Faculty Scholar Award generally involves teaching and/or research activities, the Fulbright Specialist Award supports projects such as delivering a seminar or workshop, consulting with faculty or workforce development, lecturing at the undergraduate or graduate level, and conducting needs assessment for a program or institution.  For more information or to RSVP, please contact Chris Lukasik at clukasik@purdue.edu.

 

Upcoming important deadlines and info.

Mon., Feb. 27: Center for Diabetes and Metabolic Diseases Pilot & Feasibility Grants, Letter of Intent due to Jeffrey Elmendorf (jelmendo@iupui.edu) by 5:00 p.m. See attachments for details.

Tues., Feb. 28: AAE Spring 2023 Colloquium Series, at 3:00 p.m. in ARMS 1103. Christian Franck, Bjorn Borgen Professor, Panther Program Director, and Director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison will present “Cellular NeuroMechanics-Concussions, Traumatic Brain Injury and the Mysterious Havana Syndrome.”

Wed., March 1 and Fri., March 3:  ABRCM365: Career & Research Summit, 3:00-6:00 p.m., Virtual. Are you interested in the current state of STEM careers and research? Identifying areas of opportunity and adopting strategies to meet the needs of the current landscape in STEM requires maintaining a diligent focus on current research and viable pathways. The ABRCM365 Career & Research Summit is a new 2-day virtual experience. For more information and to register, visit: https://abrcms.org/index.php/career-research-summit  Also, see attached flyer.

Wed., March 1: BME Master's Defense Announcement for Cole B. Reynolds (J. Paul Robinson, advisor), 1:00 p.m., BRK 2001 and via Zoom. Title: Novel Microfluidic Device for In-Field Purification, Amplification, and Detection of DNA from Mycotoxin-Producing Fungi.

Wed., March 1: BME PhD Final Exam Announcement for Emma Vanderlaan (S. Harbin, advisor), 1:00 p.m., MJIS 2001 and via Zoom. Title: Engineering Design of Novel 3D Microphysiological System and Sensor for Functional Assessment of Pancreatic Beta-Cells.

Thurs., March 2: BME PhD Defense Announcement for Jordanna Payne, 11:00 a.m., MJIS 2001 and via Zoom. This defense is open only to those who have signed the Lilly NDA. Title: The development, validation, and characterization of an ex-vivo porcine full thickness skin model for the study of the subcutaneous compartment. Thesis Committee: Luis Solorio, Chair; Adrian Buganza Tepole; Sherry L. Harbin; Kathy D. Miller. Zoom link: https://purdue-edu.zoom.us/j/92039572699

Wed., Apr. 5:  Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.”

 

Committee Updates

 

 

Graduate Office Update

 

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below.

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011). Details below.

 

BMEGSA General Body Meetings – All BME graduate students are welcome, and encouraged to attend! Upcoming meetings:

Friday, February 24th 11:30AM-12:30PM

Friday, March 31st 12:30PM-1:30PM

Thursday, April 20th 3:30PM-4:30PM 

All meetings are held in MJIS 2001 in person only.

 

Awards season is upon us and we will be asking for several nominations with varying deadlines over the next month.  Below is a quick snapshot of all those awards and deadlines.  More detailed emails for each award will be sent separately that will list the criteria and materials needed for the nomination. Two of them look similar (Dissertation and Outstanding Graduate Researcher) so we wanted to make sure that you knew they were actually two separate awards.

Let me know if you have any questions (tsiemers@purdue.edu).

 

Graduate Admissions Update

 

Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions

DateDATE

Activity

Mar 10

DUE: All Master’s students to be decisioned as either admit, deny or hold

Mar 31

Due: All PhD students to be decisioned as either admit, deny or hold

April 15

Graduate applicant acceptance deadline

 

 

Undergraduate Committee Update

 

CURE – Purdue accepting applications to design course-based undergraduate research - Purdue University News 

 

Purdue professional development program within the Office of Undergraduate Research is now accepting applications from instructors of any discipline for the 2023-24 academic year. CURE – Purdue seeks to develop course-based undergraduate research experiences (CUREs) across the Purdue West Lafayette campus as a way to increase undergraduate students’ overall access to novel research. The program provides instructors with the time and framework for designing a CURE, either by transforming an existing course or developing a new one. CUREs have a number of features and positive outcomes, including increasing the overall capacity for undergraduate research by operating at a larger scale than the traditional apprenticeship model and increasing inclusion by allowing any eligible student to enroll. Research findings suggest additional benefits to instructors:

 

 

Resources and further information

 

BME Distinguished Seminar Series, Wed., Feb. 22, 9:30 a.m., MJIS 1001 or via Zoom. Rita Patel, PhD, CCC-SLP, Associate Professor and Speech Language Pathologist, Department of Otolaryngology, Head and Neck Surgery, Indiana University School of Medicine, will present “An interdisciplinary scientific journey.”

Abstract: Voice pathologies occur across the life span, are disabling, interfere with gainful employment and compromise quality of life. According to the National Institute on Deafness and Other Communication 7.5 million people in the United States have voice disorders. It has been estimated that over 1 million or 6-9% children suffer from dysphonia nationwide. Estimates indicate that anywhere from 3-9% of the population has some type of voice dysfunction at any given point in time. Reported occurrence of hoarseness in the school-aged children ranges from 6%-23%. Dysphonia can be detrimental both psychologically and academically, hence early identification and restoration of optimal vocal health is critical. If untreated, dysphonia can substantially increase health care costs. Unfortunately, efficient diagnosis and effective management of voice disorders is challenged by difficulty accessing professionals with the necessary expertise and the availability of valid instrumentation to capture highly aperiodic voice qualities to diagnose and treat voice problems efficiently. To address these issues, technological advancements from a collaborative team of interdisciplinary experts in the fields of medicine, engineering, physics, and psychology show great promise for improving the efficiency and effectiveness of voice disorders assessment and treatment. This talk will focus on my current interdisciplinary work for advancing clinical assessment of voice disorders across the lifespan in the areas of laryngeal imaging, computational fluid dynamics, and mobile technology.

Biography: Dr. Rita Patel is an associate professor at the Department of Speech, Language and Hearing Sciences, Indiana University and an adjunct associate professor at the Department of Otolaryngology, Head and Neck Surgery Indiana University School of Medicine. Her research and clinical expertise focus on addressing voice and upper airway disorders in adult and pediatric population, with specialization in endoscopic laryngeal imaging. Dr. Patel has been awarded 8 extramural grants from National agencies including ASHA (American Speech Language Hearing Association) and NIH (National Institutes of Health); and 5 intramural grants. In 2022, Dr. Patel was awarded fellow by the American Speech-Language-Hearing Association (ASHA) for her outstanding contributions to research and excellent teaching in the area of voice and voice disorders. Currently, Dr. Patel serves as the editor for the American Journal of Speech-Language Pathology, American Speech-Language-Hearing Foundation’s Board of Trustees, and as an Advisory Board Member of Voice Foundation. She also serves as a reviewer for numerous journals in the fields of laryngology and speech language pathology and also serves as grant reviewer for the NIH study section, the Voice Foundation, and ASHA.

~BME Host: Young Kim~

NOTE:  Students registered for the seminar are expected to attend in-person.

Zoom link:

https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09

 

 

Seminar for Neurotrauma and Diseases, Wed., Feb. 22, 4:00 p.m., DLR 131 and via Zoom. Dr. Jimmy Dooley, Assistant Professor of Biological Sciences at Purdue will present “How movements during sleep teach infant brains how their bodies move.” The Seminar for Neurotrauma and Diseases, organized by the Center for Paralysis Research, is sponsored by Plexon, a leading neuroscience technology company, and jointly supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Join CPR and our set of amazing speakers as we explore various facets of neurotrauma and diseases and build a community to make long-lasting impacts on neurotrauma research! Seminars will be held on alternating Wednesdays from 4:00-5:00 p.m. in DLR 131, with a hybrid option on Zoom for those who cannot attend in-person at https://bit.ly/3HsTf5R .

 

RCHE Graduate Student Seminar Series, Thurs., Feb. 23:  3:00-4:00 p.m., via Microsoft Teams. Presenters include Geonsik Yu (PhD student in Industrial Engineering) and Alexis Hoerter (PhD student in Biomedical Engineering). Geonsik is advised by Yuehwern Yih in Industrial Engineering and will present on: Opinion-Disease Integrated Simulation Model: Examination of Social Features’ Impact on Disease Spread. Alexis is advised by Elsje Pienaar in Biomedical Engineering and will present on: In silico modeling of M. tuberculosis granuloma dynamics. Please mark your calendars and plan to attend at the link below. The Regenstrief Center for Healthcare Engineering brings together researchers and practitioners from multiple disciplines to pursue a proactive, patient-centered, and wellness-focused healthcare delivery system by conducting impactful research that leverages collaborative partnerships.

RCHE’s monthly Graduate Student Seminar is designed to showcase our interdisciplinary faculty and their graduate students.  With this series, we strive to foster a community of students and faculty that can share their knowledge, develop presentations skills, and engage in opportunities to collaborate all with the intention of working together to improve healthcare. 

Microsoft Teams meeting

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Meeting ID: 291 434 447 980
Passcode: wC4C9L

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purdue@m.webex.com

Video Conference ID: 113 264 504 6

Alternate VTC instructions

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AAE Spring 2023 Colloquium Series, Tues., Feb. 28, 3:00 p.m. in ARMS 1103. Christian Franck, Bjorn Borgen Professor, Panther Program Director, and Director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison will present “Cellular NeuroMechanics-Concussions, Traumatic Brain Injury and the Mysterious Havana Syndrome.”

Abstract: Current prediction, prevention and diagnosis strategies for mile traumatic brain injuries, including concussions, are still largely in their infancy due to a lack of detailed understanding and resolution of how physical forces give rise to tissue injury at a cellular level. In this talk I will present some recent work on our current understanding of the origin of concussions and traumatic brain injuries and how cells in the brain interpret and react to the physical forces of trauma. Specifically, I will show that the path to a better understanding of traumatic injuries involves addressing a variety of finite deformation, rate-dependent soft matter and cell mechanics problems along the way. Finally, I will provide an update on how our current understanding of the cellular neuromechanics cannot only help shed light on improving our prediction of TBI but also enable us to dissect the physical origin of emerging injuries such as the Havana Syndrome.

Biography: Christian Franck is a mechanical engineer specializing in cellular biomechanics and new experimental mechanics techniques at the micro and nanoscale. He received his B.S. in aerospace engineering from the University of Virginia in 2003, and his M.S. and Ph.D. from the California Institute of Technology in 2004 and 2008. Dr. Franck held a post-doctoral position at Harvard investigating brain and neural trauma. He was an assistant and associate professor in mechanics at Brown University from 2009 - 2018, and is now the Bjorn Borgen Professor in Mechanical Engineering at the University of Wisconsin-Madison. His lab at the University of Wisconsin-Madison has developed unique three-dimensional full-field imaging capabilities based on multiphoton microscopy and digital volume correlation. Current application areas of these three-dimensional microscopy techniques include understanding the 3D deformation behavior of neurons in the brain during traumatic brain injuries, and the role of non-linear material deformations in soft matter. He is the acting director of the Center for Traumatic Brain Injury at the University of Wisconsin-Madison and the ONR-funded Physics-based Neutralization of Threats to Human Tissues and Organs (PANTHER) program, which consists of over 24 PIs nationwide. Key objectives of the Panther program are in better detection, prediction, and prevention of traumatic brain injuries by providing accelerated translation from basic science discovery to civilian and warfighter protection solutions.

 

BME Master's Defense Announcement for Cole B. Reynolds, Wed., March 1, 1:00 p.m., BRK 2001 and via Zoom.

Title: Novel Microfluidic Device for In-Field Purification, Amplification, and Detection of DNA from Mycotoxin-Producing Fungi.

Advisory Committee: J. Paul Robinson, Chair; Euiwon Bae; Jacqueline Linnes

Abstract: Mycotoxins are toxic molecules produced by fungi and are harmful to human health when ingested. Mycotoxins produced by fungi that infect food crops can enter the food stream directly in manufactured produces (foods like bread) or indirectly through animal feed. Detection of mycotoxins is commonly performed after harvesting and processing of the crops because mycotoxins can increase in concentration during these steps. However, if farmers could detect the toxin-forming fungi prior to harvesting, growers can reduce cross-contamination, save wasted resources used in harvesting and processing of infected crops, and increase food safety and security. Fusarium graminearum is a fungal species that infects cereal crops and produces deoxynivalenol (DON), a harmful mycotoxin called vomitoxin. Because Fusarium graminearum has a large economic impact in the United States and globally on wheat and barley markets, it was selected as a proof-of-concept for the detection assay. For detection of fungus to be useful in determining infected areas of fields, the device must be inexpensive and portable. A low-cost, portable microfluidic device was designed to both extract the fungal DNA from wheat samples and perform a fluorescence-based loop-mediated isothermal amplification (LAMP) assay to detect the fungal DNA. Contaminated wheat samples were used to demonstrate the effectiveness of the device. The device was able to detect Fusarium graminearum in the wheat samples at concentrations relevant to DON concentration limits set forth by the U.S. Food and Drug Administration (FDA). Detection of multiple mycotoxin-producing fungal species is possible through the addition of more LAMP assays for multiplexing specific target genes.

Zoom link: https://purdue-edu.zoom.us/j/96550914018?pwd=dDQ1MkY3elArTDNTckM5MGxqdFFpZz09

 

BME PhD Final Exam Announcement for Emma Vanderlaan, Wed., March 1, 1:00 p.m., MJIS 2001 and via Zoom. Title: Engineering Design of Novel 3D Microphysiological System and Sensor for Functional Assessment of Pancreatic Beta-Cells.

Thesis Committee:  Dr. Sherry Harbin (advisor), Dr. Carmella Evans-Molina (clinical co-advisor), Dr. Hyowon Lee, Dr. Adrian Buganza Tepole, Dr. Luis Solorio 

 Abstract: Diabetes, a chronic condition characterized by elevated blood glucose levels, arises when pancreatic β-cells lose capacity to produce a robust, dynamic glucose-stimulated insulin secretion (GSIS) response. Accurate measurement of β-cell health and function ex vivo is thus fundamental to diabetes research, including studies evaluating disease mechanisms, novel drug candidates, and replacement β-cell populations. However, present-day dynamic GSIS assays typically represent end-point measurements, involve expensive commercial perifusion machines, and require time-consuming enzyme-linked immunosorbent assays (ELISA) for insulin detection. Microfluidic devices developed as accessible, low-cost alternatives still rely on secondary ELISAs and suspend islets in liquid medium, limiting their survival in vitro. Here, we present a novel, 3D-printed microphysiological system (MPS) designed to recreate components of in-vivo microenvironments through encapsulation in fibrillar type I collagen and restoration of favorable molecular transport conditions. Following computational-informed design and rapid prototyping, the MPS platform sustained collagen-encapsulated mouse islet viability and cytoarchitecture for 5 days and supported in situ measurements of dynamic β-cell function. To rapidly detect insulin secretion from β-cells in the MPS, we then developed a highly sensitive electrochemical sensor for zinc (Zn2+), co-released with insulin, based on glassy carbon electrodes modified with bismuth and indium and coated with Nafion. Finally, we validated sensor detection of Zn2+ released from glucose-stimulated INS-1 β-cells and primary mouse islets, finding high correlation with insulin as measured by standard ELISA. Together, the 3D MPS and Zn2+ sensor developed in this dissertation represent novel platforms for evaluating dynamic β-cell function in a low-cost, user-friendly, and physiologically-relevant manner.

Zoom link:

https://purdue-edu.zoom.us/j/94439715488?pwd=aElCdCt2VElmUHlMK3ZBQmF6WDZQdz09 

Meeting ID: 944 3971 5488, Passcode: 943658 

 

Frontiers in Biophysics Seminar Series, Wed., Apr. 5,  1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.” Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering.

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011).

Fall 2023, 3.0 credit hours

Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only)

Prerequisite: BME Graduate Standing

Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout.

Weekly Course Topics:

August 23            Pediatrics Introduction

August 30            Neonatology Introduction

September 6      Pediatric Device Design and Development I

September 13    Pediatric Device Design and Development II

September 20    Pediatric Device Regulation

September 27    Pediatric Clinical Studies

October 4            Pediatric Cardiology

October 18          Pediatric Cardiovascular Surgery

October 25          Pediatric Nephrology

November 1       Pediatric Pulmonology

November 8       Pediatric Wound Healing

November 15     Pediatric Gastroenterology

November 29     Ethical Considerations in Pediatrics

December 6        Future Directions and Trends

Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu

Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate.

 

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001)

 

Week

 

Date

Speaker

Host

 

Week 7

2/22/2023

Dr. Rita Patel

Associate Professor, Speech & Hearing Sciences + Associate Professor of Otolaryngology-Head & Neck Surgery at IUSM

Dr. Young Kim

Week 8

3/1/2023

Dr. Joey Wallace

Chair and Professor of BME at IUPUI

Dr. Young Kim

Week 9

3/8/2023

Dr. Hubert Lim

Professor, Department of Biomedical Engineering, Otolaryngology, Institute for Translational Neuroscience Scholar, University of Minnesota

Dr. Hugh Lee

Week 10

3/22/2023

Dr. Daniel DiLorenzo, Assistant Professor, Neurosurgery and Biomedical Sciences, Loma Linda University; Attending Neurosurgeon, Loma Linda VA Medical Center; President Barinetics Corporation

Dr. Matthew Ward

Week 11

3/29/2023

Dr. Nimmi Ramanujam

Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University

Dr. Jackie Linnes

Week 12

4/5/2023

Dr. Junhong Chen

Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory

Dr. Chi Hwan Lee

Week 13

4/12/2023

Dr. Chien-Chi Lin

Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI

Dr. Young Kim

Week 14

4/19/2023

Dr. Rachel Surowiec

Assistant Professor of BME at IUPUI

Dr. Young Kim

Week 15

4/26/2023

Dr. James Moon

J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan

Dr. Chi Hwan Lee

The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts

 

Attachments

CDMD RFA 2023.pdf

CDMD Application 2023.docx

ABRCMS365: Career & Research Summit