BME
WEEKLY ROUNDTABLE
MAY
13, 2024
COMMENCEMEN
WEEK!
INTERIM
HEAD’S NOTE
Good
morning. This is the Monday morning right after the commencement. Finally, we all can get a breather. As we pass the commencement week, I plan to skip a couple of weekly roundtables. I will still do 5/27, 6/10, and 6/24. For your information, I have started
to have weekly meetings with Dr. Kevin Otto about the transition.
Many
of us got a bit sentimental over the last weekend. I did as I attended last Thursday’s Graduate Dinner, last Saturday morning’s Graduate Celebration, and last Saturday afternoon’s Commencement Section 5. Graduation is a time for reflection. On last Thursday
evening, I asked a large crowd of graduating BME students, what kind of Purdue alum they would like to become. When thinking about this question, they could all get some help from distinguished alumni like Matthew Waninger, three-time Purdue alum and currently
Managing Director, Crossroads Pediatric Device Consortium. Matt gave an inspiring speech. Many thanks to Matt. It was so good to chat with the parents and loved ones of our graduating students on Saturday morning. Hearing their compliments about how our school
and university have well prepared their kids and loved ones to become the finest biomedical engineers or simplify seeing the smiles on their face has made all our hard work worthwhile and made all of us so proud of what we have accomplished.
It
was good to see Leo, Jackie, Tami, and Elsje at the commencement for hooding their respective students and seeing them through the journey all the way to the end. Leo also served as a Marshall beautifully. It was a good surprise to see Doug Brubaker there.
You exemplify what we stand for in this fine institution with excellent work on one of the most important missions, if not the most important one. That is, training next generations of world-class engineering researchers and independent thinkers who can go
on to save lives, improve health outcomes, and make the world a better place. Congratulations to all the graduating students who are leaving Purdue soon. I am confident that you will represent Purdue and Purdue BME so well along your exciting and successful
academic and professional career.
All
the above events were successful. Many thanks to the many organizers, Darshini, Rhonda, Pam, Susan, Tammy, and the BME student ambassadors, who put in so much energy.
In
the Staff Appreciation meeting on last Monday (5/6), we had a surprise. Asem
Aboelzahab received the Sandra K. Monroe Award. The Sandra K. Monroe (the person by Asem in the picture on the left) Excellence in Student Services Award is given annually to one student-facing professional for their policy advocacy and/or exemplary service
to students. This is a university-wide award. Attached please find a few pictures taken at the presentation. So good to see some of the graduate students who wrote the support letters came to the presentation to celebrate Asem’s achievement. So good to hear
some of the faculty’s heartfelt remarks on Asem and his great student services.
The
staff appreciation meeting was a success. It was so well organized by a few faculty members that many staff were caught by surprise. We wanted to celebrate them and thank them for all their support.
Norvin
Bruns, was selected by CSSAC Staff Excellence Award Selection Committee, as the recipient of the CSSAC Annual Service Award.
Norvin embodies excellence in every aspect of his work within the Weldon School of Biomedical Engineering at Purdue University. His dedication, initiative, exemplary
service, leadership by example, and high performance made him an exceptional candidate for this recognition. He and Asem probably are the two most known persons in the department among our students. Congratulations to Norvin.
I
will continue to do one round of acknowledgements for those who have received awards in the past academic year. The following students have received a Grubbs Undergraduate Research Scholarship:
Noah
Jasinkiewicz, Aavya Srivastava, Molly Dye, Shiv Shukla, Samantha Campbell, Aaron Coppeta, Sarah Grev, Jean-Paul Pertuit, Dalton Aaker, and Tyler Merrill. This scholarship is used to recognize students who have successfully fulfilled the requirements of BME
498 and have further showcased their research findings by presenting at a recognized conference. This reward serves as a recognition of their scholarly achievements and contributions to the field of Biomedical Engineering. Many thanks to their research advisors.
Joshua
Sexton was awarded a 1st Place Research Talk in the 2024 Spring Purdue Undergraduate Research Conference in the category of College of Engineering for the presentation “Engineered
Collagen Polymeric Materials Maintain Tissue Volume and Support Regenerative Remodeling after Volumetric Muscle Loss.” Thanks to Dr. Sherry Harbin and the staff who have helped them.
Emma
Davis, Giancarlo Mella, and Caitlin Savage were selected a Finalist (one of the top 8 teams) in the track Advanced Health Winners in the 2024 Johns Hopkins Healthcare Design Competition for their project “CardiBreath”. Thanks to Dr. Charlie Babbs.
UPCOMING
IMPORTANT DATES
Week
of May 13
Mon.,
May 13: Endo
Fellows Research Presentations,
12:00
p.m., Zoom only. Zunera Tariq, MD Fellow, Endocrinology will present “Incidence of Venous Thromboembolic Events in Patients with Endogenous Cushing’s Syndrome.” This seminar series is sponsored by the IU School of Medicine’s Center for Diabetes and Metabolic
Diseases. Zoom link: https://iu.zoom.us/j/87501979533#success
Mon.,
May 13: Purdue
Engineering Distinguished Lecture Series: From Einstein and Bell to Quantum Technologies: Entanglement in Action,
2:30
p.m., ARMS Atrium. Alain Aspect, 2022 Nobel Laureate, Professor at the Institut d’Optique – Universite Paris-Saclay, will be hosted by the College of Engineering and College of Science. The lecture will be followed by a panel (Quantum for Science, Technology
and Beyond) at 3:30 in the ARMS Atrium, with reception to follow from 4:30-5:00. Register here:
https://purdue.ca1.qualtrics.com/jfe/form/SV_2t2q54uLLJGy38W?utm_source=delivra&utm_medium=email&utm_campaign=PEDLS%20-%20Alain%20Aspect%20-%20Mar%2013%2C%202024&utm_id=46149836
Tues.,
May 14: BME
Master's Defense Announcement for Natalie Romick
(L. Solorio, advisor). Everyone is invited to attend the public presentation beginning at 1:00 PM in MJIS 2001.
Title of research: Evaluation of Biodegradable in situ Forming Implant Components to Advance Extended Release ISFI Treatment for Opioid Use Disorder.
Wed.,
May 15: BMES
2024 Annual Meeting General Abstract and Specialty Track Submission Window Closes.
See
flyer below for details. For questions regarding the general abstract submission process or becoming an abstract review, please contact
Abstracts@bmes.org
Wed.,
May 15: IBSC-BME
PhD Preliminary Examination Announcement for Worapat Sawatwong
(D. Little and D. Chan, co-advisors). Everyone is invited to attend the public presentation beginning at 10:00 AM in LYNN 1192. Research title:
Influences on Bone Mechanosensitivity: Mechanical Load Distribution History and Alterations in the Gut-Bone Axis
Wed.,
May 15: National
NIH K12 DiabDocs Career Development Session,
3:00
p.m., via Zoom. This monthly presentation features world-renowned experts via Zoom. This month’s speaker is Juan Carlos Espinoza Salomon, MD, Chief Research Informatics Officer, Stanley Manne Children’s Research Institute, Feinberg School of Medicine, speaking
on “Use of AI in Diabetes Research.”
Thurs.,
May 16: Indiana
O’Brien Center for Advanced Renal Imaging and Molecular Analysis Online Symposium,
11
a.m.-4 p.m., via Zoom. “Large-Scale 3D Microscopy as a Tool in Renal Research.” The symposium will be presented online via Zoom. Attendance is free, but requires registration at
https://iu.zoom.us/webinar/register/WN_5ZUge4PnTX6DC6eJOAF_WA#/registration
UNIVERSITY
REMINDERS
New
research security training and certification. As
we continue working to safeguard Purdue-led research against inappropriate interference by foreign entities, we have introduced a new
online
learning module for research security training
that
addresses contemporary issues and satisfies new federal requirements. We ask that all researchers within the colleges of agriculture, engineering and science and the Purdue Polytechnic Institute complete this training by Sept. 1, 2024. Read
more.
Upcoming
important deadlines and information
Thurs.,
May 23-Fri., May 24: 2024
Hitchhiker’s Guide to the Biomolecular Galaxy,
Armstrong Hall. Registration is officially open for the 2024 Hitchhiker’s Guide to the Biomolecular Galaxy! Please register using this
link.
Hitchhiker's Guide to the Biomolecular Galaxy Symposium brings together undergraduate students, graduate students, post-doctorates, and faculty throughout the Midwest who are all striving to share and gain more insight into
various biophysical approaches. Registration is completely free with breakfast, lunch, coffee, and snacks provided both days. The symposium will include a keynote address given by Dr. Jin Zhang from the University of California San Diego. Dr. Zhang’s research
lab developed a series of molecular tools and fluorescence imaging technologies to understand the spatiotemporal regulation of cell signaling.
Fri.,
May 24: BME
PhD Preliminary Examination Announcement for Jae Young Park
(Hyowon
Lee, advisor). Everyone is invited to attend the public presentation beginning at 10:00 AM in MJIS 2001.
Research title: Towards advanced implantable microsystem for minimally-invasive and precise neuromodulation
Fri.,
June 7: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor,
Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Fri.,
June 7: International Society for Applied Cardiovascular Biology Webinar,
9:00
a.m., via Zoom. Dr. Sandra Davidge, PhD, FCAHS, FRSC, Executive Director, Women and Children’s Health Research Institute, Distinguished University Professor, University of Alberta, Professor, Depts. of OB/GYN and Physiology will present “Developmental origins
of adult cardiovascular disease: Pre-clinical evidence towards improving outcomes.” Free registration at
https://isacb.wildapricot.org/event-5711321.
Organized by ISACB early career members in conjunction with the ISACB Early Career, European Partnership, and Communications Committee.
Resources
and further information
Tues.,
May 14: BME Master's Defense Announcement for Natalie Romick
(L. Solorio, advisor). Everyone is invited to attend the public presentation beginning at 1:00 PM in MJIS 2001.
Title of research: Evaluation of Biodegradable in situ Forming Implant Components to Advance Extended Release ISFI Treatment for Opioid Use Disorder.
Thesis
Committee: Luis Solorio (Chair), Kinam Park, Andrew Otte
Abstract:
Opioid use disorder (OUD) presents a challenging and nuanced condition with potential for debilitating social and physical consequences. Patients with OUD have access to treatment options, but they may
encounter issues such as diversion, invasiveness, or poor adherence. With over 2.5 million adults in the US experiencing OUD as of 2021, the need for an OUD treatment that overcomes these challenges is clear. One available treatment method is Sublocade®, a
PLGA-based in situ forming implant (ISFI) that releases buprenorphine. This treatment shows promise due to its physician administered extended release design, which addresses many current issues in OUD treatment. However, the practicality of this treatment
remains a challenge due to its monthly injection requirement. To address this, we investigated how altering ISFI components impacts the timeframe of buprenorphine release from a PLGA-based ISFI. Our focus was on evaluating factors that lead to extended buprenorphine
release while maintaining zero-order release. We varied polymer-to-solvent ratios, drug content, and solvent type, assessing their effects through drug release studies. We also conducted SEM imaging and swelling/erosion studies to evaluate polymer behavior
and implant microstructure, gaining further insights into drug release mechanisms. Our drug release studies revealed that higher buprenorphine content in the implant significantly reduced total drug release and linearized drug release patterns. Decreasing
the polymer-to-solvent ratio similarly linearized drug release and reduced drug burst, although the overall amount of drug released over time remained similar. Introducing Triacetin (TA) as a solvent helped reduce drug burst and maintain release linearity
in lower drug content implants. In higher drug content implants, TA appeared to increase drug release over time, likely due to degradation processes indicated by high swelling and increased degradation observed in SEM imaging. Erosion studies showed less implant
erosion with higher drug loading, aligning with release study observations. In conclusion, solvent type and drug content significantly influence buprenorphine release in ISFI systems and should be carefully considered when designing extended release systems
similar to Sublocade®.
Wed.,
May 15: IBSC-BME PhD Preliminary Examination Announcement for Worapat Sawatwong
(D. Little and D. Chan, co-advisors). Everyone is invited to attend the public presentation beginning at 10:00 AM in LYNN 1192. Research title:
Influences on Bone Mechanosensitivity: Mechanical Load Distribution History and Alterations in the Gut-Bone Axis
Thesis
Committee members: Dr. Dianne Little (co-chair, BMS), Dr. Deva Chan (co-chair, BME), Dr. Timothy Lescun (VCS), Dr. Andrew Brightman (BME), Dr. Glen Niebur (University of Notre Dame)
Abstract:
Osteoporosis is a bone disease that affects over 20% of the global elderly population. It is characterized by reduced bone mass and strength, leading to increased fracture susceptibility due to diminished responsiveness to mechanical stimuli. Understanding
how bones sense and respond these mechanical signals is crucial, as it directly relates to osteoporosis severity and fracture risk. There remains a critical need to identify the key factors influencing bone mechanosensation to develop effective interventions
for osteoporosis patients. Tissue-level mechanical strain directs bone adaptation. Non-physiological strain distributions can induce bone formation even under normal strain levels, highlighting the significant impact of strain distribution on bone mechanosensitivity.
Physiological strain is influenced by daily locomotion patterns, which vary across species. For instance, sprawling locomotion in reptiles with distinct stances and load distributions from quadrupedal mammals, may establish novel bone mechanosensitivity pathways.
Additionally, systemic perturbations like disrupted gut microbiome (GM) diversity – dysbiosis, alter bone homeostasis through inflammatory changes, affecting bone quality. Antibiotic use disrupts long-term GM diversity and may influence bone adaptation and
mechanosensation, while exercise may offer restoration. However, specific responses of osteocytes to different strain modes, the impact of locomotion stance on bone mechanosensitivity, and the interplay between GM dysbiosis and exercise on bone health remain
unclear. We hypothesize that these mechanical load experience and systemic interference impact bone metabolism. Aim 1 will assess the effects at the level of gene expression of different strain distribution patterns during loading using two external mouse
tibia loading models on bone cells. Aim 2 will investigate bone remodeling responses in sprawling hindlimb gait quadrupeds using iguana models. Aim 3 will study the interplay between antibiotic-induced GM dysbiosis and treadmill exercise on long-term bone
homeostasis using mouse forelimb bones. Understanding the factors influencing changes in bone mechanosensation is essential for developing new drug targets and mechanical stimulation for osteoporosis patients. Completion of this project will help me develop
the skills necessary for my long-term goal of becoming an independent researcher in musculoskeletal biology, osteoporotic disease, and sport sciences.
Wed.,
May 15: National
NIH K12 DiabDocs Career Development Session,
3:00
p.m., via Zoom. This monthly presentation features world-renowned experts via Zoom. This month’s speaker is Juan Carlos Espinoza Salomon, MD, Chief Research Informatics Officer, Stanley Manne Children’s Research Institute, Feinberg School of Medicine, speaking
on “Use of AI in Diabetes Research.” Register here: https://stanford.zoom.us/meeting/register/tJIpd--vrDwuHdKVBpS19VT6aFxYiBS_L3Nd#registration
The
program is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health under award number K12DK133995. Additional support provided by Stanford University, Indiana University, and a grant from
the Leona M. and Harry B. Helmsley Charitable Trust to Stanford University. Program questions can be directed to
diabdocsk12@stanford.edu
Brief
Bio for Speaker:
After completing his undergraduate degree at Washington University in St. Louis, Dr. Espinoza received an Intramural Research Training Award (IRTA) at the Immunotherapy Unit of the National Institute on Aging at the National Institutes of Health. At the NIH,
Dr. Espinoza worked on small molecule design, developing therapeutic and research tools. Successively, he attended the USC Keck School of Medicine, earning his MD in 2010. He completed his pediatric residency at Children’s Hospital Los Angeles in 2013, and
in 2014 he became an Assistant Professor of Clinical Pediatrics at Children’s Hospital Los Angeles and the USC Keck School of Medicine. During his time at CHLA, Dr. Espinoza’s clinical time focused on complex care coordination and obesity management, while
his research focused on informatics, medical devices, health equity, and global health. In 2016, he joined the team at CTIP (The West Coast Consortium for Technology & Innovation Pediatrics) and took over as Director and Principal Investigator in 2018 with
a new $6.6 million FDA grant. In addition to CTIP, he held a number of leadership roles in informatics and innovation, including serving as the Co-Director of Clinical Research Informatics Core for the Southern California Clinical and Translational Science
Institute, Medical Director of the Children’s Hospital Los Angeles Innovation Studio, Methods and Data Core Director for the Southern California Center for Latino Health, and Research Lead for the International Digital Health Team. In 2023, Dr. Espinoza was
recruited to Lurie Children’s Hospital to become the inaugural Chief Research Informatics Officer (CRIO) for Stanley Manne Children’s Research Institute and Associate Director of the Center for Biomedical Informatics and Data Science at Northwestern University
Feinberg School of Medicine. Dr. Espinoza’s research portfolio includes health information systems integration, social determinants of health, geocoded contextual data, regulatory science and medical device development, and patient generated health data in
diabetes, obesity, and asthma. As a clinician, he will provide inpatient care a member of the Division of Hospital-Based Medicine. His overall goal as a researcher, physician, and advocate is to identify, refine, and innovate approaches to using data and technology
to improve health outcomes and narrow the health gap faced by marginalized communities in the United States and abroad. Dr. Espinoza’s academic interests are complemented by his experiences outside of medicine; in 2010 he co-founded a digital media production
company that worked with television, film, web, and mobile technologies. In this endeavor he partnered with the entertainment and healthcare industries.
|
Thurs.,
May 16: Indiana
O’Brien Center for Advanced Renal Imaging and Molecular Analysis Online Symposium,
11
a.m.-4 p.m., via Zoom. “Large-Scale 3D Microscopy as a Tool in Renal Research.” The symposium will be presented online via Zoom. Attendance is free, but requires registration at
https://iu.zoom.us/webinar/register/WN_5ZUge4PnTX6DC6eJOAF_WA#/registration
Speakers
include:
-
Matthias
Gunzer – Inst. for Experimental Immunology and Imaging, Univ. of Duisburg-Essen
Making kidney substructures precisely countable by a combination of clearing, lightsheet imaging and automated image analysis
-
Sanjay
Jain – Kidney Translational Research Center, Washington University Nephro-neurovascular interactions in the human kidney using light sheet fluorescence microscopy
-
Christian
Kurts – Institute for Molecular Medicine and Experimental Immunology, Bonn Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by 3D fast-marching algorithm
-
Lori
O’Brien – Department of Cell Biology and Physiology, University of North Carolina
Imaging the kidney: 3D microscopy brings organization to light
-
Chetan
(Che) Poudel - Department of Chemistry, Univ of Washington Automated tracking and segmentation of whole nephrons at the organ scale
-
Victor
Puelles – Aarhus University, University Medical Center Hamburg-Eppendorf Optical clearing and advanced light microscopy to characterize glomerular pathophysiology
Thurs.,
May 23-Fri., May 24: 2024 Hitchhiker’s Guide to the Biomolecular Galaxy,
Armstrong Hall. Registration is officially open for the 2024 Hitchhiker’s Guide to the Biomolecular Galaxy! Please register using this
link.
Hitchhiker's Guide to the Biomolecular Galaxy Symposium brings together undergraduate students, graduate students, post-doctorates, and faculty throughout the Midwest who are all striving to share and gain more insight into
various biophysical approaches. Registration is completely free with breakfast, lunch, coffee, and snacks provided both days. The symposium will include a keynote address given by Dr. Jin Zhang from the University of California San Diego. Dr. Zhang’s research
lab developed a series of molecular tools and fluorescence imaging technologies to understand the spatiotemporal regulation of cell signaling.
We
will be hosting pre-symposium events on Wednesday, May 22nd 2024. Our pre-symposium events are focused on advancing careers with professional development and implementing diversity and inclusion in our field, along with social and networking opportunities
with other researchers at Purdue and the Midwest! Each day of the symposium will consist of seminar style lectures where graduate students, postdoctoral fellows, undergraduates, faculty, and visitors can share their work.
If you would like to present an oral presentation, please submit an abstract when registering
by May 10, 2024.
The
first day will also include a two-hour workshop session with four technical workshops:
-
Easy
(and accurate) structure modeling & validation on web server for cryo-EM
-
An
introduction to 3D Molecular movies (PyMOL, Chimera, Blender/Maya)
-
Figure
Making and Ethics
-
Quantitative
proteomics
When
registering for the symposium, participants will rank the order of workshops they are interested in (1 being the most likely). Participants will be placed in each workshop on a first-come, first- serve basis upon registering until the workshop reaches maximum
capacity.
On
the second day of the symposium, we will be hosting a two-hour poster session. If you would like to participate in this poster session, please submit an abstract by
May 10, 2024, when registering for the symposium! Awards will be given to the Top 3 posters and oral presentations, with a People’s Choice award at the end of the second day.
Hope
to see you all there!
On
behalf of the 2024 organizing committee:
Co-Chair,
Kadidia Samassekou (Department of Chemistry)
Co-Chair,
Vaani Ohri (Department of Biological Sciences)
Kadir
Ozcan (Department of Biological Sciences)
Hanna
Bovill (Department of Chemistry)
Ketaki
Mahurkar (PULSe/Department of Chemistry)
Michelle
Bush (Department of Biological Sciences)
Ryan
Peters (Department of
Biological Sciences)
Hunain
Janjua (PULSe/Department of Biological Sciences)
Faculty
Mentor: Dr. Lauren Ann Metskas (Department of Biological Sciences and Chemistry)
Fri.,
May 24: BME
PhD Preliminary Examination Announcement for Jae Young Park (Hyowon
Lee, advisor). Everyone is invited to attend the public presentation beginning at 10:00 AM in MJIS 2001.
Research title: Towards advanced implantable microsystem for minimally-invasive and precise neuromodulation.
Thesis Committee members: Dr. Hyowon Hugh Lee (chair, BME), Dr. Chi Hwan Lee (BME), Dr. Young L. Kim (BME), Dr. Albert Lee (BME)
Abstract: Neuromodulation
is increasingly utilized to rehabilitate a variety of biological functions, such as vision, hearing, movement, touch perception, and sense of self-movement, particularly in patients with severe or chronic diseases for whom other treatment options, including
medication, have proven ineffective. Nevertheless, due to concerns about the cost and safety of surgical processes, many are hesitant to proceed with this option. Concerns particularly arise from the potential displacement of the electrode caused by movements
at the target site due to air infiltration or cerebrospinal fluid loss during surgery. Other issues including technical errors, failure in lead fixation, Twiddler syndrome, and Pneumocephalus can also result in electrode dislocation. This misalignment can
lead to off-target effects that can have severe repercussions for patients. In address these issues, we have developed two novel platforms and accompanying surgical strategies to enable safer, more accurate, and easier implantation. To achieve these multifaceted
objectives, we designed a stretchable thin-film electronic device using polyimide-based microfabrication techniques, which is compliant to other functional medical platforms. By integrating this device with silicone catheter and adhesive hydrogel, we have
endowed the device with new functionality that facilitates novel implantation methodologies. Additionally, the third research objective of combining fractal design and surface roughening methodology led to the successful development of a highly stable stimulating
electrode.
Postdoctoral
Fellow Opportunity – IUSM Emergency Medicine
The
laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical
and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores
highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is
to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary
research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include:
(1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like
fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of
environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally.
For
additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651