*Please note the revised start time.*
BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor)
Everyone is invited to attend the public presentation beginning at 11:30AM EST.
Title: Deep brain stimulation in the
Syngap1+/- mouse model of autism and intellectual disability
Date: November 28, 2022
Time:
11:30AM EST
Location: MJIS 2001 and Zoom (meeting info below*)
Thesis Committee:
Dr. Tamara Kinzer-Ursem (Major Professor)
Dr. Maria Dadarlat Makin
Dr. Karin Ejendal
Abstract:
Syngap1+/-
haploinsufficiency is phenotypically characterized by autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy. SynGAP as a protein, is also known as Synaptic Ras GTPase-activating protein, regulating the function in synapses. Treatment-resistant
severe ASD in particular, presents concurrently with ID in 31% patients, where patients exhibit minimal speech formation, self-injurious behavior, and cognitive impairment. Previously, success in alleviating self-injurious behavior along with speech formation
was demonstrated in adolescent patients undergoing deep brain stimulation (DBS) of the basolateral amygdala (BLA). In addition, SynGAP protein is an integral component of the post-synaptic density and its role in signaling pathway converges with other autism
risk genes and consequently autism risk proteins. A critical gap exists in understanding how electrical stimulation as part of the Hebbian theory, can induce neuroplasticity. Therefore, we sought to develop a chronic DBS model in
Syngap1+/-
haploinsufficient mice that can be used to assess the behavior and proteomic correlates due to DBS in BLA. We optimized the DBS surgery and anesthesia requirements to ensure survival of
Syngap1+/-
mice as they are more susceptible to isoflurane anesthesia. Additionally, we optimized the DBS stimulation parameters in accordance with behavior responses from
Syngap1+/- mice by performing multiple trials of DBS paremeters. These methods ensure attainment of local field potentials from
Syngap1+/-
mice – future directions include verifying the role of DBS in producing theta oscillations for the purposes of memory retrieval.
*Hani Abdullah is inviting you to a scheduled Zoom meeting.
Topic: Hani Abdullah's Master's Defense
Time: Nov 28, 2022 11:30 AM America/Indiana/Indianapolis
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Meeting ID: 986 1652 1806
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