On Nov 20, 2024, at 3:30 PM, May, Sandra M <smmay@purdue.edu> wrote:

BME PhD Defense Announcement for Sang Hoon Um (L. Green, advisor)

 

Everyone is invited to attend the public presentation beginning at 10:00 am.

 

Thesis title: 

BIO-MOLECULAR TRANSPORATION VIA DNA NANOPORES IN LIVE CELL SYSTEM AND THEIR BIO-APPLICATIONS

 

Date: 12/05/2024

 

Time: 10:00 am

 

Place: MJIS 2001 and

Zoom link: https://purdue-edu.zoom.us/launch/chat?src=direct_chat_link&email=ums@purdue.edu

 

Faculty Advisor (Chair): 

Prof. Leopold Green

 

Members:

Prof. Chengde Mao

Prof. Fang Huang

Prof. Krishna Jayant

 

Abstract: 

The utilization of DNA nanopores as synthetic channels within live cell membranes represents a significant advancement in biomedical research. These nanopores, engineered with precision and versatility, offer a promising avenue for selective and efficient transport of biomolecules across cellular barriers. Leveraging the programmability and biocompatibility of nucleotides, DNA nanopores provide tailored solutions for targeted delivery mechanisms. By overcoming various challenges inherent in cellular mechanisms and synthetic pore creation technologies, including the high dependency on endocytosis machinery, the limitations posed by the size of proteins in transmembrane processes, and the biocompatibility issues associated with current technologies used to form pores, they facilitate the transportation of diverse biomolecules, including the reliance on endocytosis machinery, size limitations of transmembrane proteins, and biocompatibility issues associated with current pore-forming technologies, DNA nanopores facilitate the transport of diverse biomolecules, such as small molecules and proteins, with notable efficacy and biocompatibility. This innovation holds immense potential for various biomedical applications, offering a sophisticated platform for advanced research and therapeutic interventions throughout various cell types including eukaryotic cells and prokaryotic cells. Through elucidating the nuanced importance and diverse applications of DNA nanopores in live cell membranes, this study contributes to the ongoing progress in biomedical science and therapeutic innovation.

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