BME PhD Defense Announcement for Ziqian Zeng (N. Alves and S. Harbin, co-advisors)
Everyone is invited to attend the public presentation beginning at 9:00 AM EST.
Title: Developing in-vitro Synthetic Blood Clot Models for Testing Thrombolytic Drugs
Date: April 11, 2022
Time: 09:00 AM EST
Location:
Meeting ID: 958 7550 1047
Passcode: 636182
Committee:
Dr. Nathan J Alves (Advisor, Co-Chair)
Dr. Sherry L. Harbin (Co-Chair)
Dr. Julie C. Liu (Member)
Dr. Vitaliy L. Rayz (Member)
Abstract:
Thrombosis is the pathological blood clot formation that blocks blood circulation, leading to high morbidity and mortality rates. Thrombolytic drugs that offer rapid clot dissolution are promising
treatments, yet current drugs are associated with limited efficacy and high bleeding risks. While numerous animal thrombosis models have been developed for drug screening, the translation of therapeutic agents into and through clinical trials remains limited.
This is primarily due to animal models’ poor reproducibility and distinctive physiology to that of humans. In vitro flow models that utilize both human blood components and physiologically relevant flow conditions can provide for a more representative testing
environment to screen drugs. Developing better in vitro models may not eliminate the need for preclinical animal testing but can help exclude inefficient agents earlier in the drug development pipeline to expedite the drug evaluation process. Existing in vitro
thrombolysis flow models are not ideal as they either adopt over-simplified clot substrates or utilize small-length-scale geometries that insufficiently mimic native hemodynamics. Thus, we propose to develop a highly reproducible, physiological scale, flowing
clot lysis model to screen thrombolytic drugs. This model combines an in vivo-like fluorescence incorporated synthetic clot (FISC) and a human-relevant flow system. This system is a tubing-based structure comprising a peristaltic pump, a dampener, and a fluorometer
to offer real-time monitoring of thrombolysis under steady or pulsatile flow. The synthetic clot model can mimic various thrombosis conditions and offer representative drug testing and dosing results across numerous thrombolytic agents.
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Ziqian Zeng is inviting you to a scheduled Zoom meeting.
Topic: Ph.D. Final Exam for Ziqian Zeng
Time: Apr 11, 2022 09:00 AM EST
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Meeting ID: 958 7550 1047
Passcode: 636182
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Meeting ID: 958 7550 1047
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