BME
WEEKLY ROUNDTABLE
WEEK
OF SEPTEMBER 4, 2023
INTERIM
HEAD’S NOTE
I
hope you had a good Labor Day weekend and got a chance to get your breath with your busy work.
Please
find the attached memo from Provost Wolfe and VP Rollock of Ethics and Compliance on Reportable Outside Activities (ROA). Few key points from the memo:
-
All
Reportable Outside Activities must be disclosed for the current fiscal year, which began July 1 and ends June 30, 2024. This can be done through logging in to the
online
reporting system
or on the Employee
Portal
-
A
campus-wide email has been sent to all faculty and exempt staff on August 28 requiring them to indicate their status of ROA.
-
All
faculty and exempt staff within our unit must complete ROA report by September 15 with one of the following two options:
- Certify
no Reportable Outside Activities, or
- Fill
out the Reportable Outside Activities Form.
- Those
who fail to report or gain approval for Reportable Outside Activities are subject to discipline and/or penalties, including the possible impact on funding and more.
I
have been discussing the agenda of the BME Advisory Board meeting with many of you. Thank you for those of you who have agreed to attend and present in the meeting.
It
is time to get the preparation of our next faculty meeting (September 29) under way. Your suggestions are welcome. We will have Joyce Main to come to talk about the COACH Survey data.
I
again copy and paste the updates from Andrew and Hugh in the following. They wanted to give the following updates in our first department faculty meeting.
Updates
from Andrew Brightman on Graduate Committee and Grad Programs:
-
As
the semester gets underway, remember that graduate students enrolled in research will need to meet with their primary faculty mentors to
set research expectations (see attached) for the semester and then the faculty member will need to
alert the graduate school when these requirements are set for each RA you are mentoring. These meetings are also a good time to review
Student-Advisor Expectation Scales (see attached) as well as IDPs (individualized Development Plans -
see links below) with each student you mentor to help them set goals for the semester and year ahead.
https://engineering.purdue.edu/BME/Academics/Graduate/PhDMilestones/PhD_Milestone_Timeline_Fall_2022
Here is the milestone timeline if that is helpful.
-
Second-year
PhD students
will need to begin preparations for completing their Preliminary
Exam due at the end of the year two.
Guidelines and rubrics for the new processes for these exams are being refined by the Grad Committee and will be distributed later this fall to faculty and these students.
-
The
Grad Committee collected feedback from faculty and students last spring on the
new processes for Qualifying Exams. The Committee is reviewing the feedback and making revisions to the processes and related documents based on the recommendations.
-
The
new Graduate
Student Handbook for BME
was completed, published on line and distributed to incoming grad students this summer
thanks to the huge efforts of the Grad Programs Staff and Committee Chair, Mike Heinz. This handbook is primarily for the newest students and their faculty mentors, but has information helpful to all graduate students. Feedback on this version will
be collected in the Spring from faculty and students and the Graduate School and an updated version will be created each summer.
Updates
from Hugh Lee on Graduate Admissions
·
Changes to admissions
o
Guidance document to be distributed; see the attachment.
o
Holistic evaluation, no consideration for race in any admission decision
·
New “Academic” Statement of Purpose
o
Professional and career goals
o
Research interests
o
Experiences
o
Fit with school
·
Includes Personal History Statement now
o
How background and life experiences prepared candidate
o
If academic records do not reflect your true capabilities explain circumstances
·
Opportunities for students and faculty to attend and advertise at the following conferences
o
October 26 – 28th – Society
of Women Engineers (SWE) National Conference –
Los Angeles, CA
o
November 1 - 5th –Society
of Hispanic Professional Engineers (SHPE) National Convention –
Salt Lake City, UT
o
March 20 – 24th 2024 – National
Society of Black Engineering (NSBE50)
– Atlanta, GA
o
Looking for faculty interested in serving in person or online on a faculty panel/workshop at the Society of Hispanic Professional Engineers (SHPE) Conference
UPCOMING
IMPORTANT DATES
Week
of September 4
Tues.,
Sept. 5: IBSC-BME
PhD Defense Announcement for Yuhyun Ji
(Y. Kim, advisor), 9:30 a.m., MJIS 2001. Title of presentation: “Bridging Color to Spectrum for Biophotonics.”
Wed.,
Sept. 6: BME
Research Seminar,
9:30
a.m., MJIS 1001 or via Zoom. Kun Hang, PhD, Chair, Department of Biostatistics and Health Data Science, Indiana University School of Medicine, will present “Computational Pathology and Integrative Genomics for Human Disease Research.”
(Note: Students
registered for the seminar are expected to attend in-person.)
Wed.,
Sept. 6: BMES
Early Bird Registration Deadline! Register
now to lock in savings with early-bird pricing for the 2023 BMES Annual Meeting (to be held in Seattle, WA, October 11-14). Thousands of biomedical engineers will attend this year’s meeting to learn, collaborate, and network. As a BMES member, you can save
more than 10% with reduced early bird rates, so if you’re not already a member, now would be a good time to join! Click here for details:
https://mailchi.mp/e3958bb463f2/o8cvhb9q5x-9335625?e=ea10e317a2
NOTE:
We recommend booking your room at the Hyatt Regency Seattle because it’s
closer to the convention center AND it’s where university receptions will be held (in addition to some being held
inside the convention center). Here’s the link to reserve with the $259 discount rate.
This rate only lasts until the allotted number of rooms have been sold.
https://www.hyatt.com/en-US/group-booking/SEARS/G-BMES
Wed.,
Sept. 6: Symposium
of the Women’s Global Health Institute (WGHI), 11:00
am-3:30 pm, South Ballroom, PMU. This year’s Symposium of the Women’s Global Health Institute (WGHI) at Purdue will feature
Dr. Christiane Kuhl, Chair of Diagnostic and Interventional Radiology at the University Hospital in Aachen, Germany, and an absolute rock-star in breast imaging, to give the keynote lecture at 1:00 pm about breast cancer screening, entitled “Breast Cancer
Screening: New Ways of Thinking".Dr. Kuhl is an outstanding speaker to any audience, who has given some famous keynote addresses at international conferences like ISMRM or RSNA. Her talk will provide an overview on the current evidence as well as controversies
regarding breast cancer screening, including AI-based risk prediction. Furthermore, the WGHI symposium also features some of our own Purdue research on breast cancer imaging, e.g. with the talk of Dr. Joseph Rispoli on “Advances in Breast Radiofrequency Coils
for MRI”. Registration is
free, and if anybody is interested in talking to Dr. Kuhl in a small group setting or individually the day before the symposium, on Sept 5, please let me know, and we can try to fit you into her agenda! Informational flyer is attached.
Thurs.,
Sept. 7: Seminars
in Hearing Research,
12:00 noon, Nelson Hall Room 1215. Dalton J. Aaker (BME undergrad) will present “Decoding fNIRS Neural Responses: A Machine Learning Approach.”
This
year’s SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule
Titles
and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts
Fri.,
Sept. 8: Abstract
Submission Deadline for The Trauma THOMPSON Challenge.
The
primary goal of The Trauma THOMPSON Challenge is to encourage research to build better algorithms for autonomous instruction systems in uncontrolled and austere environments, especially for life-saving procedures. The envisioned algorithms include action recognition,
action anticipation, procedure recognition, and visual question answering (VQA). The challenge participation details are below.
Fri.,
Sept. 8: Seminar
for Neurotrauma and Diseases, 4:00
p.m., DLR 131 and via Zoom. Charles Babbs, MD, PhD, will present “The brain’s waste disposal systems: How glymphatic flow happens.” The Seminar for Neurotrauma and Diseases is organized by the Center for Paralysis Research and is sponsored by Plexon. Join
CPR and our set of amazing speakers as we explore various facets of neurotrauma and diseases and build a community to make long-lasting impacts on neurotrauma research. Zoom link:
https://bit.ly/441Dllq
MJIS
Updates
Our
semi-annual air handling shutdown is tentatively scheduled for Tuesday, October 10th.
As
a reminder: the entire building air handling system in MJIS will be turned off.
ALL chemical hood activity, biosafety cabinet activity, autoclave work and activities in wet labs will need to
STOP by 5 PM on Monday, October 9th. Any chemicals stored in the hoods will have to be sealed at that time. Signs will be posted on all hoods to remind users not to use the hoods
Monday evening, and removed when the maintenance work is completed and normal operations can resume.
Please plan ahead - DO NOT use chemicals in the lab areas that you would normally use in the hoods.
Antimicrobial
Resistance Seminar Series - Purdue
The
College of Veterinary Medicine and Institute for Drug Discovery want to invite you to join fellow scientists at Purdue for the launch of the inaugural Antimicrobial Resistance (AMR) Seminar series. According to the U.S> Centers for Disease Control and Prevention
and the Food and Drug Administration, 2.8 million antibiotic-resistant infections occur annually in the US, resulting in 35,000 deaths. Combating AMR requires multifaceted efforts both the healthcare and veterinary sectors. In response to this critical public
health threat, scientists at Purdue are working together to increase awareness and discover solutions for advanced diagnostics, treatment, and prevention. Starting on
September 13,the AMR Seminar Series will be held in person at the Lobby Conference Room at the Institute for Drug Discovery (from 12 p.m. to 1 p.m.).
Please let us know if you are interested in giving a talk for the series. Faculty, graduate students and postdocs who want to participate are welcome to present; please send names and email addresses to
amr-purdue@purdue.edu
A
schedule will be coming soon.
Upcoming
important deadlines and information
Mon.,
Sept. 11: BME
PhD Defense Announcement for Sang Mok Park
(Y. Kim, advisor), 3:00 p.m., MJIS 2001 and via Zoom. Title: Tissue Optics-Informed Hyperspectral Learning for Mobile Health.
Fri.,
Sept. 15: Deadline
to submit Reportable Outside Activities. Please
find the attached memo from Provost Wolfe and VP Rollock of Ethics and Compliance on Reportable Outside Activities (ROA). Few key points:
- All
Reportable Outside Activities must be disclosed for the current fiscal year, which began July 1 and ends June 30, 2024. This can be done through logging in to the
online
reporting system
or on the Employee
Portal
-
An
campus wide email will be sent to all faculty and exempt staff on August 28 requiring them to indicate their status of ROA.
-
All
faculty and exempt staff within your unit must complete ROA report by September 15 with one of the following two options:
- Certify
no Reportable Outside Activities, or
- Fill
out the Reportable Outside Activities Form.
- Those
who fail to report or gain approval for Reportable Outside Activities are subject to discipline and/or penalties, including the possible impact on funding and more.
- Pls
convey the important of complying the ROA to your faculty and exempt staff.
Fri.,
Sept. 15: Deadline
to register as an NSF Graduate Research Fellowship Program Reviewer. Serving as a National Science Foundation (NSF)
Graduate
Research Fellowship Program
(GRFP) reviewer is a real opportunity to help shape the future of science. The
deadline to register interest in serving as a reviewer is September 15, 2023. We know that reviewing for GRFP is a significant commitment and are extremely grateful to all of our STEM colleagues
who are able to serve as reviewers! If you are available, please complete your registration at
https://nsfgrfpreviewers.org.
Please
Note: All potential reviewers must register for the FY24 competition, regardless of previous review service.
If
this is your first time registering as a potential reviewer for GRFP, please login or create an account at
https://nsfgrfpreviewers.org.
If
you have registered in a previous year, you may login using your existing password. Should you need to reset your password,
please visit https://nsfgrfpreviewers.org/login.jsp.
Thank
you in advance for your willingness to serve! We look forward to receiving your completed registration for the FY24 competition! If you have questions or need additional assistance, please email us at
reviewers@nsfgrfp.org.
Please
feel free to share this opportunity with your colleagues. GRFP is still recruiting reviewers in all STEM fields of study.
Sincerely,
GRF
Operations Center
reviewers@nsfgrfp.org
www.nsfgrfp.org
Sun.,
Sept. 17: BME
Professional Master’s Program Community Service Event, 1:00
p.m., Riehle Plaza, downtown Lafayette. BME PMP will be raising funds for the Hunger Hike this year. Proceeds will go to help
fight hunger both in Greater Lafayette and in Haiti. If you would like to help support this cause, please use the link below.
Donation
Link
(choose Weldon School of Biomedical Engineering Grad Programs)
You
are also more than welcome to join our team and walk with us. If you are interested in joining our team, please use the directions below to sign-up.
To
join the team/walk, text HHIKE37 to 71777.
1.
Create your own personal page
2.
Join our team “Weldon School of Biomedical Engineering Grad Programs”
Thanks
for your consideration in supporting hunger and our PMP grad students.
Fri.,
Dec. 1: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate
Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Fri.,
March 1: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate
Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Fri.,
June 7: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor,
Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Resources
and further information
IBSC-BME PhD Defense Announcement for Yuhyun Ji
(Y. Kim, advisor), Tues., Sept. 5, 9:30 a.m., MJIS 2001. Title
of presentation: “Bridging Color to Spectrum for Biophotonics.”
Examining committee:
Dr. Young L. Kim, Chair, Dr. Stephen B. Hooser, Dr. Yunjie Tong, Dr. Maria C. Makin
Abstract: Advancements in machine learning are narrowing the gap in visual capabilities between machines and
healthcare professionals, resulting in a transformation of the way we understand and address health challenges. Despite these advances, underlying limitations persist in addressing real-world problems, particularly in the precise capture of biological and
physiological information. This is primarily because traditional trichromatic cameras fall short of representing reflectance spectra due to their limited spectral information. To overcome these limitations, hyperspectral imaging has emerged as a powerful tool
for biomedical applications. By collecting a wealth of information at different wavelengths, hyperspectral imaging provides a comprehensive view of electromagnetic spectra, allowing non-invasive clinical analysis for accurate diagnostics. Snapshot hyperspectral
imaging, in particular, is a competitive alternative to traditional cameras as it can capture a hyperspectral image in a single shot without the need for scanning individual wavelengths. Here, we introduce a computational snapshot hyperspectral imaging method,
achieved through the integration of a machine learning approach with a streamlined optical system. We design an explainable machine learning algorithm by incorporating optical and biological knowledge into the algorithm. Therefore, the algorithm can reconstruct
hyperspectral images with high spectralspatial resolution comparable to those of scientific spectrometers, despite the use of sparse information captured from the optical system. To demonstrate its versatility in biomedical applications, we extract hemodynamic
parameters of peripheral microcirculation from embryonic model systems, tissue phantom samples, and human conjunctivas. Furthermore, we validate high accuracy of the results using conventional hyperspectral imaging and functional near-infrared spectroscopy.
This learning-powered imaging method, characterized by high resolution and simplified hardware requirements, has the potential to offer solutions for various biomedical challenges by surpassing the constraints of conventional cameras and hyperspectral imaging.
BME Research Seminar,
Wed., Sept. 6,
9:30 a.m., MJIS 1001 or via Zoom. Kun Hang, PhD, Chair, Department of Biostatistics and Health Data Science,
Indiana University School of Medicine, will present “Computational Pathology and Integrative Genomics for Human Disease Research.”
Abstract:
Computational pathology is an emerging research area straddling artificial intelligence,
computer vision, and biomedical imaging. Besides its applications in disease diagnosis and prognosis, computational pathology is a powerful phenotyping tool for quantitatively measuring cellular and tissue morphology in disease tissues such as cancer biopsy
samples. The extracted quantitative morphological features can be integrated with multi-omics data to generate new biological hypothesis regarding cancer development and new integrative markers predicting clinical outcomes for patients. In this talk, I will
give any overview of our work in computational pathology and integrative genomics based on machine learning methods with applications in diseases such as cancer and Alzheimer’s disease.
Biography:
Dr. Kun Huang is an internationally recognized leader in bioinformatics and computational pathology. He joined the Regenstrief Institute in 2017 as part of a joint appointment with the Indiana University School of Medicine, where he is now the chair of Biostatistics
and Health Data Science. His research interests lie in translational bioinformatics, computational pathology, medical imaging, computational biology, integrative genomics for precision health, computer vision, and machine learning. He is focused on developing
translating informatics tools to improve clinical practice and accelerate scientific discovery and believes the Precision Health Initiative is an unprecedented opportunity to accomplish just that.
~
BME Host: Young Kim
~
Zoom link:
https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09
Seminars in Hearing Research,
Thurs., Sept. 7, 12:00 noon, Nelson Hall Room 1215. Dalton J. Aaker (BME undergrad) will present “Decoding fNIRS Neural Responses: A Machine Learning Approach.”
Abstract:
The aim of this project is to explore a machine learning model that accurately identifies positive auditory-evoked neural responses while controlling for factors that introduce noise to the neural signal and observe the effects of decoding these interferences.
Human neuroimaging data collected via functional near-infrared spectroscopy (fNIRS) from a single subject twice daily for five consecutive days was analyzed. The data followed a block-design paradigm with two conditions: meaningful auditory speech and silence
serving as a baseline control. Hemoglobin concentration data was collected using a continuous-wave fNIRS system (NIRx NIRSport2) with specific source-detector pairs optimized for brain regions associated with sound perception and language comprehension. Standard
fNIRS data cleaning and preprocessing practices were applied, and Python's Sci-kit learn library was utilized for decoding and prediction on the extracted datasets. Estimators were trained on hemoglobin concentrations and applied stimuli, with cross-validation
using Stratified K Folding. Some estimators required training on both systemic physiological and fNIRS datasets, using a feature union technique to join the relevant features. Preliminary analysis revealed that the model achieved the strongest predictive ability
using only the oxygenated hemoglobin signal. At low subject counts, the best decoding accuracies were achieved using a combination of Galvanic Skin Response (GSR) and oxygenated hemoglobin signals. In general, physiological data did not consistently improve
decoding accuracy, except for GSR data. This study provides insights applicable to machine learning, neuroscience, and optical engineering and the ability to combine cofactors for maximum prediction capabilities in machine learning models is a key area of
ongoing research.
This year’s SHRP schedule is available
here: https://purdue.edu/TPAN/hearing/shrp_schedule
Titles and abstracts of all SHRP talks
are here: https://purdue.edu/TPAN/hearing/shrp_abstracts
BME PhD Defense Announcement for Sang Mok Park
(Y. Kim, advisor), Mon., Sept. 11,
3:00 p.m., MJIS 2001 and via Zoom. Title: Tissue Optics-Informed Hyperspectral Learning for Mobile Health.
Examining committee members: Dr. Young L. Kim, Chair, Dr. Craig J. Goergen, Dr. Jacqueline Linnes, Dr. George
T. Chiu (ME)
Abstract:
Blood hemoglobin (Hgb) testing is a widely used clinical laboratory test for various patient care needs. However, conventional blood Hgb measurements involve invasive blood sampling, causing iatrogenic blood loss. Although noninvasive blood Hgb prediction
methods are under development, their performance often does not align with clinical laboratory blood Hgb tests. Optical spectroscopy can provide reliable blood Hgb tests, but its diagnostic applications are limited by bulky optical components, high costs,
and slow data acquisition. Mobile health (mHealth) colorimetric diagnostics have a potential for point-of-care blood Hgb testing. However, achieving diagnostic color accuracy is a complex matter, affected by device models, light conditions, and image file
formats. To address these limitations, we propose biophysics-based algorithms that combine hyperspectral learning and spectroscopic gamut-informed learning for reliable mHealth blood Hgb quantification. The palpebral conjunctiva serves as an ideal peripheral
tissue site, owing to its easy accessibility, relatively uniform microvasculature, and absence of skin pigmentation. First, hyperspectral learning reconstructs a high-resolution spectrum of the palpebral conjunctiva from red-green-blue values of a digital
camera, eliminating the need for complex and costly optical instrumentation. Second, spectroscopic analyses of peripheral tissue establish a unique color gamut and design diagnostic reference colors highly sensitive to blood Hgb. Informed by tissue optics
and machine vision, the Hgb gamut-based learning algorithm offers device/light/format-agnostic color recovery of the palpebral conjunctiva. This mHealth blood Hgb assessment exhibits comparable accuracy to capillary blood sampling tests over a wide range of
blood Hgb values. Importantly, a single-shot photograph allows noninvasive, continuous, and real-time Hgb readings in resource-limited and at-home settings. Furthermore, our biophysics-based digital health approaches can lay the foundation for personalized
medicine and facilitate the tempo of clinical translation.
Zoom link:
https://purdue-edu.zoom.us/j/4572570338
BME Weekly Research Seminars
|
Week
# |
Date |
Speaker |
Title |
Host |
Website |
|
3 |
9/6/2023 |
Kun Huang |
Professor and Chair, Department
of Biostatistics and Health Data Science, Indiana University School of Medicine |
Young Kim |
|
|
4 |
9/13/2023 |
Bomyi Lim |
Assistant Professor of Chemical
and Biomolecular Engineering, University of Pennsylvania |
David Umulis |
|
|
5 |
9/20/2023 |
Rainer Fischer |
Research Professor Department
of Comparative Pathobiology Purdue University College of Veterinary Medicine |
Young Kim |
|
|
6 |
9/27/2023 |
Omer Inan |
Linda J. and Mark C. Smith Chair
Professor at Georgia Tech |
Young Kim |
|
|
7 |
10/4/2023 |
Alexander Chubykin |
Associate Professor Department
of Biological Sciences Purdue University |
Fang Huang |
|
|
8 |
10/11/2023 |
Kyung Sung |
Chief of Cellular and Tissue
Therapy Branch, FDA |
Young Kim |
|
|
9 |
10/18/2023 |
Alan Grodzinsky |
Professor of Biological, Electrical,
and Mechanical Engineering Department of Biological Engineering, MIT |
Deva Chan |
|
|
10 |
10/25/2023 |
Nian Wang |
Assistant Professor of Radiology
& Imaging Sciences, Indiana School of Medicine |
Yunjie Tong |
|
|
11 |
11/1/2023 |
Ben Gaston |
Billie Lou Wood Professor of
Pediatrics Indiana University School of Medicine |
George Wodicka |
|
|
12 |
11/8/2023 |
Jean-Pierre Mobasser
|
Affiliate Clinical Faculty |
Young Kim |
https://www.goodmancampbell.com/our-team/team-member/jean-pierre-mobasser-md |
|
13 |
11/15/2023 |
Jane Grande- Allen |
Isabel C. Cameron Professor
of Bioengineering, Rice University |
Deva Chan |
|
|
14 |
11/29/2023 |
Sarah Wiehe |
Jean and Jerry Bepko Professor
of Pediatrics Indiana University School of Medicine |
George Wodicka |
|
|
15 |
12/6/2023 |
Robbee Wedow |
Assistant Professor of Sociology
and Data Science, |
David Umulis |
https://www.robbeewedow.com/?_ga=2.88497945.389094989.1679581193-1816225309.1603576015 |
Postdoctoral Fellow Opportunity – IUSM Emergency Medicine
The laboratory of Dr. Nathan J. Alves, PhD, within the Department of
Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director
of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering
and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely
digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis,
blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity
and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like
fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of
environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally.
For additional information and to apply,
go to: https://indiana.peopleadmin.com/postings/19651
REGISTRATION NOW OPEN FOR
|
|
Dear Indiana CTSI Colleagues, |
Attachments
Student-Advisor Expectation Scales
BME_Graduate_Research_Credit_Expectations_Form_Fa22
Admissions Guidance Aug 2023 FINAL
WGHI Symposium
Reportable Outside Activities Memo