BME
WEEKLY ROUNDTABLE
February
12, 2024
INTERIM
HEAD’S NOTE
- On
behalf of the department, I want to start this note by welcoming the three newest members of the Weldon family. They are Cory Wilfong, Senior Program Assistant, Ali Acosta and Lora McDaniel, Research Technologists. They all started on Monday (2/12). Welcome!
- On
behalf of the department, I sent out courtesy appointment offer letters to a number of University Tenure faculty members affiliated with Purdue BME Indy site. I am glad that a few of them have signed the letter and returned it to me with their acceptance.
- In
last
Friday’s
faculty meeting, we welcomed Kimberly Dixon and Chloe Cronk, Business Managers, Engineering Administration. They have officially replaced Ben Overly. From now on, please direct your business management related questions to them. They now spend a few days each
week in our building (MJIS 3001).
- A
“Teaching Load Working Group” is being formed and we
invite all faculty who are not already involved and would like to be to join. Vitaliy and I would hope to have representation from faculty of all ranks. Please email
vrayz@purdue.edu by
tomorrow to be added to the group. I will work Vitaliy to finalize the composition of this working group within a week after tomorrow.
- Finally,
for those who celebrated the Lunar New Year last weekend, I hope you enjoyed it immensely.
UPCOMING
IMPORTANT DATES
Week
of February 12
Wed.,
Feb. 14: BME
Distinguished Seminar Series,
9:30
a.m., MRGN 121 and via Zoom. Donny Hanjaya-Putra, Assistant Professor of Aerospace and Mechanical Engineering, University of Notre Dame will present “Designing Biomaterials to Deliver Stem Cells and Therapeutics.”
Thurs.,
Feb. 15: Seminars
in Hearing Research,
12:00
noon, LYLE 1160. Lisa Goffman, PhD (SLHS Distinguished alum) will present “A developmentally grounded account of sequential pattern learning deficits in developmental language disorder.”
MJIS
ALERT
MJIS
Air Handling Shutdown, Tues., March 12
beginning at 7:30 AM and lasting until approx. 3:00 PM for preventative maintenance of the building’s air systems. This includes air ventilation supplies to all public, classroom and research areas, including chemical fume hoods. There should be NO chemicals
used anywhere! All chemical fume hood activity should terminate by 5 PM Monday March 11th. You must make sure all chemical containers are sealed at that time. Chemical fume hoods will have notices posted - do not resume activity until BME staff have verified
that work is complete, and have removed postings.
2024
BME Research Symposium: Innovations in Biomedical Engineering
BMEGSA
is excited to announce the 2024 BME Research Symposium to be held on April 16th, 2024 in the Hall for Discovery Learning Research (DLR) in Room 131 from 9:30 a.m. – 4:30 p.m.
Abstracts
submissions are now open! All BME-affiliated undergraduate, post-bacs, and graduate students are welcomed to submit an abstract. The submission is open to both West Lafayette and Indianapolis campus.
All abstract submissions are due by March 19th at 11:59pm on the submission
portal.
We encourage all students to apply, and please ensure your abstract follows the directions provided in this email.
There will be cash prizes and awards for the top oral and poster presentations!
For
all attendees, please complete the registration form for the BME Symposium, which can be found
here.
There is no cost to register for the symposium.
If
you have any questions, please reach out to Brendan (bbkazu@purdue.edu)
or Lizzy (frazie34@purdue.edu)
via email.
Graduate
Recruiting
Purdue’s
College of Engineering Graduate Recruitment office will be recruiting in Colombia from February 18th to March 1st. Colleen Coulter, Assistant Director of Graduate Recruitment, plans to visit Bucaramanga, Pereira, and Bogota with a group from EducationUSA.
She will connect with Purdue-specific partners in Barranquilla (U. Del Norte), Cali (ICESI U.), and Medellín (U. EAFIT). If you have faculty and/or students in Colombia that you want Colleen to connect with during this trip, please alert her by email:
clc@purdue.edu.
Virtual
Workshop Series on Mastering Grant Writing
Tommy
Sors, Director of Scientific Strategy and Relations, invites you to elevate your research potential by registering to be part of our exclusive workshop series, meticulously designed to guide you through the competitive landscape of NIH funding and the art
of grant writing. Each session builds on the next, so you want to make sure to catch all sessions because they offer the knowledge and tools to craft winning proposals. Sessions ran on Thursdays from 2:00-3:00 p.m. November 30 – December 14 and will continue
Tuesdays 10:00-11:00 a.m. January 9-Feb. 13. Register at https://purdue.ca1.qualtrics.com/ife/form/SV_01WMuhATStggQOW
Career
Resources: Purdue Lecture Hall Series and Pathfinder Podcasts
Purdue
Lecture Hall Series: A Global Scientific Journey
What's
Inside: This series showcases the diverse and fascinating journeys of graduate students and postdocs at Purdue University as they navigate the world of scientific research.
Why
Watch: Each lecture is not just a story of scientific inquiry, but a tale of personal and cultural enrichment, highlighting the global nature of our scientific community.
Share
with Students: These narratives offer invaluable insights and inspiration for anyone embarking on a career in science.
Explore
the Series: With over 30 lectures already available and many more to come, there’s a wealth of knowledge to be discovered.
📺
Watch Here: Purdue
Lecture Hall Series on YouTube
Pathfinder
Podcast: Navigating Careers Beyond Academia
What's
Inside: In our Pathfinder series, we delve into the lives of individuals working in life sciences companies, exploring the various career paths and successes achievable beyond the academic realm.
Why
Listen: These interviews provide rare insights into industry careers, offering guidance and motivation for those considering or preparing for a transition from academia to industry.
A
Resource for Aspiring Scientists: Many of our interviewees express wishing they had access to such insights during their graduate studies. This series is a perfect tool to broaden your students' understanding of potential career trajectories in life sciences.
📺
Watch Here: Pathfinder
on YouTube
Upcoming
important deadlines and information
Mon.,
Feb. 19 – Fri., Feb. 23: Fulbright
Week.
Purdue's
Fulbright Week will start you on your way to applying for the Fulbright U.S. Student Program. Fulbright U.S. Student Grants offer a fully funded post-baccalaureate year to study, research, or teach abroad. Sessions will be held in-person with a virtual option
unless otherwise noted. Sessions are a mix of in-person and remote offerings. See below for details.
Tues.,
Feb. 20: Purdue
Engineering Distinguished Lecture Series,
Lecture
at 1:30 p.m. and Panel at 2:30 p.m., ARMS Atrium. Russell Allgor, Vice President and Chief Scientist, Worldwide Operations at Amazon.com will present “Structuring Amazon’s outbound network to scale.” Hosted by the College of Engineering and the School of Industrial
Engineering. Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_7P75FDaroDkuwVo?utm_source=delivra&utm_medium=email&utm_campaign=PEDLS%20-%20Russell%20Allgor%20-%20Feb%2020%2C%202024&utm_id=45804663
Wed.,
Feb. 21: BME
Distinguished Seminar Series:
9:30
a.m., MRGN 121 and via Zoom.
Leonardo
A. Rivera-Rivera, PhD, Associate Scientist, Department of Medicine and Medical Physics, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin – Madison will present “Elucidating cerebrovascular disease pathways to cognitive decline with neurofluid
imaging.”
Wed.,
Feb. 21: Purdue
Engineering Distinguished Lecture Series. Russell
Allgor, Vice President and Chief Scientist, Worldwide Operations at Amazon.com will present “Logistics and Fulfillment Systems for E-Commerce.” This seminar is hosted by the College of Engineering, and School of Industrial Engineering. Register at bit.ly/pedls-allgor
Wed.,
Feb. 21: Seminar
for Neurotrauma and Diseases,
4:00-5:00
p.m., DLR 131 and via Zoom. Vijay Rangachari, PhD, Professor of Biophysical Chemistry, University of Southern Mississippi will present “α-synculein modulates TDP-43 phase transitions to induct heterotypic amyloids – Implications in Neurodegenerative diseases.”
Zoom link: http://bit.ly/42hhhJG
The seminar series is sponsored by the Center for Paralysis Research and Plexon.
Thurs.,
Feb. 22: BME
PhD Defense Announcement for Neal Patel
(V.
Rayz, Chair), 10:30 a.m., MJIS 2001 and via Zoom.
Title: Characterization of Neurofluid Flow using Physics-Guided Enhancement of 4D flow MRI.
Wed.,
Feb. 28: BME
Distinguished Seminar Series,
9:30
a.m., MRGN 121 and via Zoom. John Oshinski, Professor of Radiology & Imaging Sciences and Biomedical Engineering, Emory University/Georgia Tech will present “Measuring
Neural Dynamics with MRI.”
Thurs.,
Feb. 29: Purdue
University 3rd Annual Health Equity Summit,
8:00
am to 3:00 pm, PMU North and South Ballrooms. Hosted by Dr. Jerome Adams and Purdue’s Health Equity Initiatives Team with Indiana CTSI.
Fri.,
March 1: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate
Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Wed.,
March 6: Purdue
Engineering Distinguished Lecture Series. Karen
Willcox, Director, Oden Institute for Computational Engineering and Sciences, Associate Vice President for Research, and Professor of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin will present “From Reduced-Order Modeling
to Scientific Machine Learning: How Computational Science is Enabling the Design of Next-Generation Engineering Systems.” This seminar is hosted by the College of Engineering, and School of Mechanical Engineering. Register at bit.ly/pedls-willcox
Fri.,
March 8: Bottorff
Graduate Fellowship Program Applications
due. Please see the attached Bottorff Fellowship application form for Summer 2024. The Bottorff Graduate Fellowship Program is designed to increase the number of Purdue doctoral engineering students focused on
medical technology innovation and clinical translation. Funds to support a summer clinical immersion experience are available to help students gain clinical exposure at the Indiana University School of Medicine (IUSM). This
full-time 8-week summer clinical immersion experience will be followed by a fall class focused on biomedical product translation (BME 56100 Preclinical and Clinical Study Design or BME 59500 Biomedship). Finally, a spring Regulatory class will help fellows
understand the workings of the US FDA and other regulatory agencies and the steps needed for clinical translation. Applications are due by Friday, March 8th.
Contact
Aaron Lottes (lottes@purdue.edu)
or Craig Goergen (cgoergen@purdue.edu)
for questions about the program.
Mon.,
March 11 – Friday, March 15: Spring Break.
Tues.,
March 12: MJIS Air Handling Shutdown, beginning at 7:30 AM and lasting until approx. 3:00 PM for preventative maintenance of the building’s air systems. This includes air ventilation supplies to all public, classroom and
research areas, including chemical fume hoods. There should be NO chemicals used anywhere! All chemical fume hood activity should terminate by 5 PM Monday March 11th. You must make sure all chemical containers are sealed at that time. Chemical fume hoods will
have notices posted - do not resume activity until BME staff have verified that work is complete, and have removed postings.
Mon.,
March 18: Engineering
in Medicine Pediatrics Research Symposium, 10:00
am – 3:00 pm, Joseph E. Walther Hall, R3 C203, 980 W. Walnut St, Indianapolis. The day will include scientific sessions, networking, a poster session and expert panels on industry partnerships, leveraging resources, and success stories. Register by March 7th:
https://redcap.link/nixel8sz
The Symposium is sponsored by Crossroads Pediatric Device Consortium, The Indiana University School of Medicine, and Purdue University College of Engineering.
Tues.,
March 19: Abstracts
submissions for the 2024
BME Research Symposium: Innovations in Biomedical Engineering
are due by March 19th at 11:59pm on the submission
portal.
All BME-affiliated undergraduate, post-bacs, and graduate students are welcomed to submit an abstract. The submission is open to both West Lafayette and Indianapolis campuses. We encourage all students to apply, and please ensure your abstract follows the
directions provided in this email. There will be cash prizes and awards for the top oral and poster presentations!
The Symposium will take place on April 16 in the Hall for Discovery Learning, Room 131. If you have any questions, please reach out to Brendan (bbkazu@purdue.edu)
or Lizzy (frazie34@purdue.edu)
via email.
Thurs.,
April 4: 19th
Annual Garnet E. Peck Symposium, France
A. Cordova Recreational Sports Center. Registration now open: www.purdue.edu/conferences/Peck2024
. The Peck Symposium will showcase the digital transformations occurring in the pharmaceutical industry. Presentations include the latest developments in discovery, data analysis, process development and the application of AI in the pharmaceutical industry,
as well as a poster session and 3-minute student thesis competition. Chaired by Dr. Nathaniel Milton, Professor of Practice. Questions? Email Cindy Everhart, IMPH Communications & Events Coordinator,
ceverha1@purdue.edu
Sat.,
April 6: E-Waste
Day, 8:00
a.m. – 2:00 p.m., Tippecanoe County Fairgrounds (1190 Teal Road, Lafayette).
Our
bi-annual e-waste event is back on April 6th from 8am-2pm at the Tippecanoe County Fairgrounds! This event includes FREE electronics recycling, paper shredding, and medicine disposal for Tippecanoe County residents!
Details
on E-waste Recycling:
Tippecanoe County residents may bring in electric and electronic devices such as TVs, computers, laptops, vacuum cleaners, printers, etc. for recycling at no charge. We will NOT accept items with refrigerant such as AC units, refrigerators, dehumidifiers,
or freezers. We will NOT accept large appliances such as washing machines or stoves. Those can be recycled at Oscar Winski Scrap Metal at 2407 N 9th St. All attendees must show proof of Tippecanoe County residency to receive free service.
Details on paper shredding: A paper shredding truck will be on-site to accept up to two banker boxes of paper to shred and recycle from each car. Just pull up, dump your box in the bin, and that's it! Paper clips, staples, folders, and file tabs are
A-OK! Please remove binders and alligator clips.
Details on medicine take-back: The Tippecanoe County Sheriff's Department will also be here to accept any unused or expired medicines. Over-the-counter and prescription (including controlled substances) are accepted. It will be dumped out onsite, so
bring it loose if possible! All of your medicines will be destroyed and disposed of safely. We will not take liquids, needles of any kind, insulin, or powders.
We will have volunteers on hand to unload your electronics. Please have them packed in your vehicle in an easy-to-unload manner so that we can keep the line of cars moving.
Wed.,
April 10: Purdue
Engineering Distinguished Lecture Series. Jeffrey
Dean, Google Senior Fellow and SVP of Google Research and Google Health, Google Research will present “Machine Learning, AI and Applications of AI.” This seminar is hosted by the College of Engineering, and Elmore Family School of Electrical and Computer Engineering.
Register at bit.ly/pedls-dean
Fri.,
June 7: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor,
Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Resources
and further information
Mon.,
Feb. 12: Biological
Sciences Seminar Series,
11:30
a.m., DLR 131. Joseph Mougous, PhD, University of Washington, Seattle and Howard Hughes Medical Institute will present “Mechanisms and Consequences of Interbacterial Warfare.”
Abstract:
Interbacterial
antagonism is one of the most ancient and prolific biological processes on earth. Discovering the myriad mechanisms underlying this process and defining their physiological significance are primary focuses of my laboratory, and in this seminar I will highlight
examples of our contributions in the area. This will include our discovery that the type VI secretion system mediates interbacterial antagonism via the delivery of a cocktail of mechanistically distinct toxins and our recent identification of a structurally
novel antibacterial particle produced by Streptomyces and related Actinobacteria.
Wed.,
Feb. 14: BME
Distinguished Seminar Series,
9:30
a.m., MRGN 121 and via Zoom. Donny Hanjaya-Putra, Assistant Professor of Aerospace and Mechanical Engineering, University of Notre Dame will present “Designing Biomaterials to Deliver Stem Cells and Therapeutics.”
Abstract:
Stem cells respond to many cues from their microenvironment, which may include chemical and mechanical signals. These important cues can be incorporated into biomaterials to control stem cell differentiation and morphogenesis. Here, we discuss our recent
efforts to design synthetic biomaterials as a modular platform to direct stem cell fate and morphogenesis into the blood and lymphatic vasculatures. First, we have used multilamellar lipid nanoparticles to rejuvenate vascular progenitor cells and improve their
therapeutic potential. By controlling the release kinetic of various bioactive molecules to the surface of vascular progenitor cells, we not only improve cell migration, but also augment their angiogenic potential
in vitro and in vivo. Second, we have used hyaluronic acid (HA)-based hydrogels to promote lymphatic network formation. By tuning the mechanical properties of the hydrogels, we have demonstrated that HA-hydrogels preserve key lymphatic phenotypes
and matrix stiffness primes lymphatic tube formation directed by VEGF-C. Finally, we have utilized alternating current (AC) electrospray to encapsulate stem cells and produce granular hydrogels. The electrically induced “tip streaming” mode has enabled high-throughput
encapsulation of stem cells with high efficiency and universality. Collectively, these recent advances in biomaterials design and fabrication provides us the opportunity to control stem cell differentiation and morphogenesis for a range of biomedical applications.
Biography:
Donny
Hanjaya-Putra is an Assistant Professor in the Department of Aerospace and Mechanical Engineering, Bioengineering Graduate Program, and member of the Harper Cancer Research Institute at the University of Notre Dame. His research focuses on the study of thrombosis
and hemostasis, stem cell engineering, vascular and lymphatic morphogenesis, as well as synthesis of bio-inspired
materials and tissue-engineered constructs. His lab is interested to understand what governs the formation of blood and lymphatic vessels from stem cells and how these insights can be used to develop novel therapies. He has received numerous awards, including
NIH Maximizing Investigator’s Research Award R35, NSF CAREER Award, Career Development Award from American Heart Association, CMBE Young Innovator Award, and Siebel Scholar Award. Research projects in his lab are currently being supported by both federal and
private funding agencies, including NSF, NIH, American Cancer Society, DoD Advanced Regenerative Manufacturing Institute (ARMI) / BioFab USA, and American Heart Association.
~
BME
Host: Taimoor H. Qazi ~
ZOOM
LINK: https://purdue-edu.zoom.us/j/95943871353?pwd=eUdrd1pxVzRhTUlsdzM5ZGJma2o4UT09
Students
registered for the seminar are expected to attend in-person.
Thurs.,
Feb. 15: Seminars
in Hearing Research,
12:00
noon, LYLE 1160. Lisa Goffman, PhD (SLHS Distinguished alum) will present “A developmentally grounded account of sequential pattern learning deficits in developmental language disorder.”
Abstract:
Infants are able to learn sound patterns that obligate local sequential dependencies that are no longer readily accessible to adults (Gerken et al., 2019). However, adults can learn similar patterns that do not require attention to sequential dependencies.
Interestingly, the sound pattern learned so readily by infants is the second most frequent morphophonological pattern across human languages: thus, infants’ ability to learn this pattern may underlie the observation that acquiring a language early in life
is important for the development of mature performance. This surprising developmental trajectory, in which infants and young children show learning skills that adults do not, also raises intriguing questions about learning in a group of children characterized
by their language difficulties—those with developmental language disorder (DLD). Children with DLD show deficits in the organization of sequential patterns in both language production and non-linguistic motor skill. Thus, DLD does not appear to be a disorder
of speech, language, or motor skill, but rather an impaired ability to detect and deploy sequential dependencies over multiple domains. We propose that sequential dependency learning is required for frequently encountered phonological and morphosyntactic patterns
in natural language as well as other domain general abilities, and deficits in children with DLD interfere with learning of these sequential dependencies. However, patterns that do not rely on sequential dependencies are learnable by children and adults with
DLD.
This
year’s SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule
Titles
and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts
Mon.,
Feb. 19 – Fri., Feb. 23: Fulbright
Week.
Purdue's
Fulbright Week will start you on your way to applying for the Fulbright U.S. Student Program. Fulbright U.S. Student Grants offer a fully funded post-baccalaureate year to study, research, or teach abroad. Sessions will be held in-person with a virtual option
unless otherwise noted. Sessions are a mix of in-person and remote offerings.
Mon 2/19 Kickoff
Event HCRN 1066
6-7:30pm Giant Leaps
Toward a (Ful)Bright Future: Celebrating 10 Years of Fulbright Success through NISO
Tues 2/20
Information Sessions HCRS 1076
1:30pm Fulbright for Graduate Students
2:30pm 2025-26 English Teaching
Assistant Grants
5:30pm 2025-26 Research and Study
Grants
Wed 2/21 Information
Sessions HCRS 1054
4:30pm 2025-26 Research and Study
Grants
5:30pm 2025-26 English
Teaching Assistant Grants
6:30pm Fulbright for STEM majors
Thurs 2/22
Duhme Hall Living Room
6-7:30pm Fulbright:
Around the World in 90 Minutes
Fri 2/23
WALC 2051
10:00-11:00 am Fulbright Scholar
Grants (Faculty only)
All sessions are 45 minutes unless
noted
Additional information available
at: https://www.purdue.edu/niso/fulbright/fulbrightweek.html
Wed.,
Feb. 21: BME
Distinguished Seminar Series:
9:30 a.m.,
MRGN 121 and via Zoom.
Leonardo A. Rivera-Rivera,
PhD, Associate Scientist, Department of Medicine and Medical Physics, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin – Madison will present “Elucidating cerebrovascular disease pathways to cognitive decline with neurofluid imaging.”
Abstract:
While Alzheimer’s disease (AD) is the most prevalent cause of dementia, postmortem examinations reveal that at least half of clinically diagnosed AD patients exhibit cerebrovascular disease (CVD), potentially contributing to cognitive impairment and
dementia. Despite this association, the mediation pathways between AD, related dementias, and vascular disease remain poorly understood, and treatments often overlook the multi-etiological nature of dementia. To provide insights into AD and CVD relationships,
non-invasive Magnetic Resonance Imaging (MRI) is being utilized in longitudinal studies involving AD risk-enriched populations. However, current clinically available MRI techniques lack sensitivity and specificity to address key vascular hypotheses in such
studies. MRI methods commonly employed today, such as fluid attenuation and susceptibility imaging only indirectly characterize CVD and cannot inform on the dynamic neurofluid flow and vascular motion phenomena that are hypothesized to interact with AD related
pathology. This presentation will introduce a variety of MRI strategies designed to improve the characterization of CVD in the context of aging and AD, including a description of challenges associated with technical and physiological variability. Findings
from risk-enriched populations and biomarker-confirmed AD patients will also be presented.
Biography:
I
obtained a Bachelor of Science in Applied Physics from the University of Puerto Rico – Humacao. Subsequently, I completed my Ph.D. in Physics at UW-Madison, focusing on the optimization of MRI methods for assessing cerebrovascular hemodynamics under the guidance
of Dr. Oliver Wieben. Following my doctoral studies, I pursued a post-doctoral fellowship at the same institution, where I worked on accelerated Non-Cartesian sampling acquisition and constrained image reconstruction methods for neuroimaging. This included
work on motion-encoded pulse sequences and contrast-enhanced MRI, supervised by Dr. Kevin M. Johnson. Currently, I serve as an Associate Scientist at the Wisconsin Alzheimer’s Disease Research Center at UW-Madison. In this role, I collaborate closely with
investigators from the Departments of Medical Physics, Radiology, Medicine, and Kinesiology. My research interests revolve around the development of sensitive markers for the characterization of cerebrovascular health, employing innovative MRI methods across
various stages from data acquisition and image reconstruction to post-processing strategies.
~
BME
Host: Vitaliy Rayz ~
Zoom
link:
https://purdue-edu.zoom.us/j/98045041653?pwd=S3E4czF3d2RWNkdybUtWbzJ5MHpZQT09
Note:
Students registered for the seminar are expected to attend in-person.
Thurs.,
Feb. 22: BME
PhD Defense Announcement for Neal Patel (V.
Rayz, Chair), 10:30 a.m., MJIS 2001 and via Zoom.
Title: Characterization of Neurofluid Flow using Physics-Guided Enhancement of 4D flow MRI.
Thesis Committee:
Dr. Vitaliy Rayz (Chair), Dr. Edward Delp, Dr. A.J. Schwichtenberg, and Dr. Michael Markl
Abstract:
Cerebrospinal
fluid (CSF) plays a diverse role within the skull including cushioning the brain, regulating intracranial pressure, and clearing metabolic waste via the glymphatic system. Disruptions in CSF flow have long been investigated for hydrocephalus-related diseases
such as idiopathic normal pressure hydrocephalus (iNPH). Recently, changes in CSF flow have been implicated in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease. It remains difficult to obtain in vivo measurements of CSF
flow which contribute to disease initiation, progression, and treatment. Three-directional phase-contrast MR imaging (4D flow MRI) has been used to measure CSF velocities within the cerebral ventricles. However, there remain challenges in balancing acquisition
time, spatiotemporal resolution, and velocity-to-noise ratio. This is complicated by the low velocities and long relaxation times associated with CSF flow. Additionally, flow-derived metrics associated with cellular adaptations and transport rely on near-wall
velocities which are poorly resolved and noisy. To address these challenges, we have applied physics-guided neural networks (PGNN) to super-resolve and denoise synthetic 4D flow MRI of CSF flow within the 3rd and 4th ventricles using novel physics-based loss
functions. These loss functions are specifically designed to ensure that high-resolution estimations of flow fields are physically consistent and temporarily coherent. We apply these PGNN to various test cases including synthetically generated 4D flow MRI
in the cerebral ventricles and vasculature, in vitro 4D flow MRI acquired at two resolutions in 3D printed phantoms of the 3rd and 4th ventricles, and in vivo 4D flow MRI in a healthy subject. Lastly, we apply these physics-guided networks to investigate blood
flow through cerebral aneurysms. These techniques can empower larger studies investigating the coupling between arterial blood flow and CSF flow in conditions such as iNPH and AD.
Zoom
link:
https://iu.zoom.us/j/88597603864
Wed.,
Feb. 28: BME
Distinguished Seminar Series,
9:30
a.m., MRGN 121 and via Zoom. John Oshinski, Professor of Radiology & Imaging Sciences and Biomedical Engineering, Emory University/Georgia Tech will present “Measuring
Neural Dynamics with MRI.”
Abstract:
Brain tissue and cerebral spinal fluid (CSF) move in response to changes in blood pressure/flow over the cardiac cycle. This is referred to as
Neural Dynamics. Magnetic resonance imaging (MRI) can be used to study CSF flow pulsations using
phase contrast magnetic resonance (PCMR). We have recently developed an MRI method to measure motion of the brain parenchyma using
displacement encoding with simulated echoes (DENSE). We applied PCMR and DENSE to look at coupling of CSF flow and brain motion in the setting of Chiari Malformation, a disease where the cerebellar tonsils drop below the foramen
magnum. MRI scans were performed in a series on 100+ Chiari Malformation
patients where ~half
underwent treatment by posterior fossa decompression surgery. We examined changes in neural dynamics (CSF flow and brain motion) between healthy subjects and Chiari Malformation patients, and in Chiari Malformation patients before and after surgery. The
goal of the project is to: 1) understand pathophysiology of Chiari Malformation, 2) predict effects of surgery on neural dynamics, and 3) develop better methods of selecting patients for surgical treatment.
Biography:
John
Oshinski, PhD is a Professor of Radiology & Imaging Sciences at Emory and Biomedical Engineering at Emory University and Georgia Tech. He was trained as a mechanical Engineer and has spent 25 years using imaging and experimental and computational fluid mechanics
to study the relationship between hemodynamics and vascular disease in the clinical environment. His research program focuses on developing new imaging and modelling applications that improve the diagnosis of cardiovascular disease, influence patient care
decisions, and enable a better understanding of basic cardiacvascular physiology and pathophysiology. Dr. Oshinski also serves as director of the Emory Center for Systems Imaging (CSI), and integrated core facility that houses all the research imaging equipment
in the Emory school of Medicine (3T and 7T human MRI scanners, human PET/CT and PET/MR scanners, animal MRI and PET/CT, cyclotron, and Radiopharmacy).
~
BME
Host: Vitaliy Rayz ~
Zoom
link: https://purdue-edu.zoom.us/j/99721542345?pwd=SnpHdjhWWlFWTmVMSzd1WS9teC9NZz09
Note:
Students registered for the seminar are expected to attend in-person.
Thurs.,
Feb. 29: Purdue
University 3rd Annual Health Equity Summit,
8:00
am to 3:00 pm, PMU North and South Ballrooms. Hosted by Dr. Jerome Adams and Purdue’s Health Equity Initiatives Team with Indiana CTSI. The event will feature Francis S. Collins, MD, PhD, Senior Investigator at the National Human Genome Research Institute
and former Director of the National Institutes of Health. What to expect: Lunch and collaborative opportunities at NO cost, innovative health equity topics, and poster session with awards ceremony. Register for the event today at
https://web.cvent.com/event/aa2fe096-8206-4093-85f2-6c22e8baad1c/summary
BME
Distinguished Seminar Series,
9:30
a.m., MRGN 121 (NOTE LOCATION CHANGE) or via Zoom.
Zoom
link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09
Note: Students registered for the
seminar are expected to attend in-person.
|
Week
# |
Date |
Speaker |
Title |
Host |
Website |
|
6 |
2/14/2024 |
Donny
Hanjaya-Putra |
Assistant
Professor, Aerospace and Mechanical Engineering, U of Notre Dame |
Taimoor
Qazi |
|
|
7 |
2/21/2024 |
Anne
Robertson |
Distinguished
Service Professor, Department of Mechanical Engineering and Materials Science, Swanson School of Engineering, University of Pittsburgh |
Vitaliy
Rayz |
https://www.engineering.pitt.edu/people/faculty/anne-robertson/ |
|
8 |
2/28/2024 |
John
Oshinsk |
Professor
in the Emory/Georgia Tech Department of Biomedical Engineering and Department of Radiology and Imaging Sciences, Emory University School of Medicine |
Vitaliy
Rayz |
https://www.cores.emory.edu/csic/about/faculty-staff/oshinski-john.html |
|
9 |
3/6/2024 |
Melissa
Kemp |
Carol
Ann and David D. Flanagan Professor, Georgia Cancer Coalition Distinguished Cancer Scholar, Georgia Tech |
Elsje
Pienaar |
|
|
10 |
3/20/2024 |
Jerome
Mertz |
Professor,
Biomedical Engineering, Boston University |
Krishna
Jayant |
|
|
11 |
3/27/2024 |
Mikhail
G. Shaprio |
Professor
of Chemical Engineering, Caltech |
Krishna
Jayant |
|
|
12 |
4/3/2024 |
Jennifer
Linderman |
Pamela
Raymond Collegiate Professor of Engineering, University of Michigan |
Kinzer-Ursem Pienaar |
|
|
13 |
4/10/2024 |
Victor
Barocas |
Professor,
Department of Biomedical Engineering, University of Minnesota |
Deva
Chan |
|
|
14 |
4/17/2024 |
Kim
“Avrama” Blackwell |
Professor
and DEO of Roy J. Carver Department of Biomedical Engineering |
Kinzer-Ursem |
|
|
15 |
4/24/2024 |
Stacey
Finley |
Nichole
A. and Thuan Q. Pham Professor and Associate Professor of Biomedical Engineering, Chemical Engineering and Materials Science, and Quantitative and Computational Biology, USC |
Kinzer-Ursem Pienaar |
Postdoctoral
Fellow Opportunity – IUSM Emergency Medicine
The
laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical
and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores
highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is
to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary
research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include:
(1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like
fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of
environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally.
For
additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651
Attachments:
BME_Symposium_Flyer
2024 03 18 EiM symposium flyer