BME WEEKLY ROUNDTABLE

WEEK OF October 23, 2023

 

 

INTERIM HEAD’S NOTE

 

Happy Halloween! Will you do trick-and-treating tonight? My 12-year-old daughter is so looking forward to it with her friends. She participated in the costume contest last Friday at school. She went in with a group of friends for the group costume award category, dressing herself up like the 70s. She got a turtle-neck for the contest, for which she particularly went to the Goodwill store in town. I saw what she got and I was like I have a lot of those in my closet. Time flies. 😊    

 

We have completed the interviews of our Marketing & Communications Specialist position. We interviewed four qualified candidates in the past 2 weeks. We selected them from more than 22 applicants. We initially contacted five finalists for interview. One withdrew at the last minute. We spent one hour with each of the four candidates. Questions include, not exclusively, 1) what are the strategies to improve the image and reputation of the school facing outward; 2) what are some of the events you organized for building up the image; 3) what do you see your strengths and weaknesses; and 4) how do you work on a team and managing student helpers, especially under deadline pressure; and 5) how are you familiar with the operations of a department and major events taking place throughout the year.  Jo has sent out a Qualtrics survey to the interviewers to solicit evaluation and feedback. We would like to decide the first person we want to offer the job to by the end of this week. We can then move on to the offering phase. Many thanks to Jo who is taking us through the finish line. Thanks to Tammy, Darshini, Cindy, Young, and Vitaliy for participating the interviews. 

 

The faculty should all receive an email from Luna Lu calling for nominations for the College of Engineering Faculty Excellence Awards. Anyone is free to nominate anyone. This is an important opportunity to recognize our colleague’s work and express our appreciation for their contributions and achievements. While application to most of the awards is due on Feb 1, 2024, it is the time to think carefully and strategically given these awards are quite competitive and preparing materials take time. I am aware that Chi Hwan, our awards committee chair has been active. I use this as the first prompt. The committee wants to come up with a short list soon and work with the nominators and nominees.

 

Ascension Health / Purdue BME workshop will take place today. All BME faculty are welcome to join the workshop at around 2:45 pm. We will start breakout group discussions by then. The two main themes are 1) cardiology and 2) neurology. Two additional themes are digital health and AI/ML in clinical practice, and clinical administration and health systems management. After the group discussions, we will bring all of us together to identify a few common areas/projects of interest. 

 

Tomorrow’s BME Research Seminar will be featuring one of our closest colleagues from IUSM. Dr. Gaston, an Adjunct Professor of the Weldon School of Biomedical Engineering, has helped the Weldon School in so many different ways. For more information, please see later in this email.

Wed., Nov. 1: BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Benjamin Gaston, MD, Billie Lou Wood Professor of Pediatrics, Indian University School of Medicine and Vice Chair for Translational Research, Riley Children’s Hospital will present “Current Translational Research on Childhood Breathing Disorders.”

 

BMEGAS will have a graduate student resume review workshop next Monday (11/6) from 1 to 2 pm in MJIS2001. While they have gotten a couple of volunteers, I still encourage you to stop by if you have time to help out. Well placing our graduate students (especially PhDs) is a key mission to me in advising my research group. It will pay the dividends definitely in the long run for improving the image and ranking of the school. Placing your students well often starts with critiquing their resumes.

 

UPCOMING IMPORTANT DATES

 

Week of October 30

 

Mon., Oct. 30: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon, R4-101 (Indianapolis) and via Zoom. James Lo, MD, PhD, Associate Professor of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine will present "Adipose Regulation of Metabolic Health and Disease." This seminar is sponsored by the IU School of Medicine and the Center for Diabetes and Metabolic Diseases. Zoom link: https://iu.zoom.us/s/87501979533 

 

Wed., Nov. 1: BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Benjamin Gaston, MD, Billie Lou Wood Professor of Pediatrics, Indian University School of Medicine and Vice Chair for Translational Research, Riley Children’s Hospital will present “Current Translational Research on Childhood Breathing Disorders.”

 

Thurs., Nov. 2: Institute for Cancer Research Seminar, 11:30 a.m., Drug Discovery (DD) Conference Room. Juhun Lee, Associate Professor of Radiology, University of Pittsburgh, will present “Advancing Breast Cancer Detection with AI: Leveraging Bilateral Asymmetry, Simulated Mammograms Using GANs, and Cautionary Considerations.”

 

Thurs., Nov. 2:  Seminars in Hearing Research, 12:00 noon, Nelson Hall, Room 1215. Leroy Medrano, AUD Student, SLHS will present “Reliability of audiovisual temporal window measurements.”

 

Sun., Nov. 5:  DON’T FORGET TO CHANGE YOUR CLOCKS! Eastern Daylight time ends on Sunday, November 5th, at 2:00 a.m.  “Spring ahead, fall behind…”

 

MJIS ALERT

 

The MJIS passenger elevator will be DOWN on Wednesday, November 1st from 7:00 am – 11:00 am for preventative maintenance/part replacement. The analog stairways will still be functioning normally.

 

As of Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m.  Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required, including required use of area codes for ALL calls. See link below for details.

 

Graduate Programs Update

 

Are you interested in establishing and implementing your own approaches to teaching undergraduates? Are you looking for a meaningful teaching experience to put on your resume/CV? If so, please consider applying for the College of Engineering Dean's Teaching Fellowship!

 

What: Be the Instructor for a Course in your School

When: Two Semesters | Spring/Summer 2024 apprenticeship followed by Summer/Fall 2024 Instructorship

Deadline: Applications are due by Wednesday, November 1st, 2023. Applicants must include an endorsement form from their School/Division (details in attached .pdf) and should allow time to secure this before the deadline!

 

Apply here: https://purdue.ca1.qualtrics.com/jfe/form/SV_cCuy9sXBciXIiuW

 

Details:

 

Who: Eligibility is listed in the attached document. Must be a College of Engineering PhD student from a participating school (see attached). Must be perceived by the student’s advisory committee chair as having high potential to be successful in academia.

Please note: Your School may have its own specific Teaching Fellowship with a similar deadline, and the College Dean’s Teaching Fellowship cannot be awarded in the same year to a graduate student who has received a Teaching Fellowship through their own School.

 

Please see the attached announcement for additional details. The goal of this College of Engineering Dean’s Teaching Fellowship is to provide additional opportunities for you to teach during your senior graduate school years, which can also be excellent training for graduate students planning to pursue faculty careers.

 

The 2024 Dean’s Teaching Fellows will be selected by the College of Engineering's review committee, and applicants will be notified by December 15, 2023. We highly encourage students from all backgrounds to apply for this opportunity.

 

Please let me know what questions you have!

 

Stephen M. McBride, Ph.D.

Assistant Director, Graduate Student Success
College of Engineering - Graduate Education

Purdue University

Neil Armstrong Hall of Engineering

ARMS 1233
701 West Stadium Avenue
West Lafayette, IN 47907

mcbrid44@purdue.edu

www.engr.purdue.edu/grad

 

Upcoming important deadlines and information

 

Mon., Nov. 6:  Midwest Mechanics Seminar 2023, 3:30 p.m., ARMS B071. Dr. Alison Marsden, Douglass M. and Nola Leishman Professor of Cardiovascular Disease, Professor of Pediatrics and Bioengineering, and by courtesy of Mechanical Engineering, Institute for Computational and Mathematical Engineering, Stanford University, will present “Multi-physics Modeling of Flow and Cardiac Function in Pediatric Cardiology.”

 

Thurs., Nov. 9:  BME PhD Preliminary Exam for Grigorii Rudakov (T. Kinzer-Ursem and L. Green, co-advisors). Everyone is invited to attend the public presentation beginning at 9:00 am in MJIS 2001. For coffee and bagels come 15 minutes early. Title: DNA Tetrahedron Design Optimization for Efficient Drug Delivery Through the Blood-Brain Barrier.

 

Wed., Nov. 29:  Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Koji Uchida, Professor of Food Chemistry, University of Tokyo will present “Conversion of Proteins into DNA Mimetics by Reactive Aldehydes.” This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq. For additional information, see https://vet.purdue.edu/cpr/

 

Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m.  Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required. See link below for details.

 

Fri., Dec. 1:  Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar

 

Fri., Dec. 1:  Indiana Life Sciences Conference – “Closing the Gap[ of Health Inequalities,” 8:00 a.m. – 3:15 p.m., Roche Diagnostics, Indianapolis. See below for details.

 

Fri., March 1:  Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar

 

Fri., June 7:  Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar

 

Resources and further information

 

Wed., Nov. 1: BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Benjamin Gaston, MD, Billie Lou Wood Professor of Pediatrics, Indian University School of Medicine and Vice Chair for Translational Research, Riley Children’s Hospital will present “Current Translational Research on Childhood Breathing Disorders.”

AbstractI will give a brief overview of my lab group’s principal translational projects. These have to do with several disorders of childhood breathing. First, I will discuss apnea and opioid-induced respiratory depression, addressing how and why ATLX-0199 can reverse drug-induced respiratory depression. Then, I will discuss Primary Ciliary Dyskinesia (PCD): how we establish a PCD diagnosis in genotype-negative patients; how PCD cells be corrected and grown on an implantable matrix; and how we are improving diagnosis and management of PCD in Africa. Next, I will discuss viral pneumonia and bronchiolitis, specifically including a promising new potential approach for treating COVID, RSV and metapneumovirus. Next, I will discuss bronchopulmonary dysplasia (BPD), reviewing whether we might be able to treat we treat BPD and tracheomalacia with GSNO. Finally, I will go over our translational work on asthma. Specifically, whether GSNO can be used to treat asthma, with FeNO as a biomarker; whether Cavosonstat may be able to benefit an ADH5 genotype-targeted severe asthma population; whether DHEA could benefit and HSD3B1 genotype-targeted population; whether inhaled Optate could decrease asthmatic airway inflammation, and whether ciliary dysfunction predisposes to asthma.

Biography: Dr. Gaston is Vice Chair for Translational Research at Riley Hospital for Children. He went to college and to medical school at the University of Virginia.  He did his military service (USS Iwo Jima) and Pediatric training (Bethesda) in the United States Navy.  He trained in Pediatric Pulmonology at Boston Children’s Hospital.  He has been continuously funded by the NIH for 25 years, and currently is PI on a P01 to study airway epithelial biology.  He also is PI or CoI on several other grants, including the PrecISE asthma intervention trial and an R33 in continuity with an R44/SBIR focused on developing a novel respiratory stimulant. He and his collaborators have several other small grants, including grants on PCD; and the P01 is flexible enough to help support PCD research.  He has over 230 publications.  He has helped to found several companies focused on translating discoveries for the benefit of children with respiratory diseases.  Currently, most of his clinical work and a good deal of his research is focused on improving the diagnosis and management of PCD. He and his wife have three wonderful children.

~ BME Host: George Wodicka ~

Note:  Students registered for the seminar are expected to attend in-person.

Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09

 

Thurs., Nov. 2:  Seminars in Hearing Research, 12:00 noon, Nelson Hall, Room 1215. Leroy Medrano, AUD Student, SLHS will present “Reliability of audiovisual temporal window measurements.”

Abstract:  The temporal binding window (TBW) is a period of time where two stimuli presented at different times are perceived as one event. This is a way to measure how the brain integrates different stimuli, and to see if individuals can distinguish the temporal delay between a pair of stimuli. The use of visual and auditory stimuli has been used more in prior multisensory integration studies, and the results from these studies have been used to compare individuals with typical sensory and cognitive functions with individuals who have impairments in these domains. These conclusions are built on differences that aren’t supportable without some reliability measurements. Therefore, we aim to measure the consistency of temporal binding windows across different visits using audio-visual stimuli. Temporal binding window measures were collected in 10 participants (ages 19 – 58) with normal hearing and no history of vestibular disease. Each participant was tested twice at separate visits (at baseline, and on average 7 days later) using a fixed psychophysical procedure that consisted of subjective responses of either “flash” or “beep” in each trial. Preliminary results using both Generalized Linear Model (GLM) and Bayesian parameters suggest that there may not be consistency across visits at the group level when using linear regression analysis. Further research and analysis will include a larger sample size to account for variance, Karolinska Sleepiness Scale (KSS) data analysis to see if subjective sleepiness can influence performance, and perhaps increasing the number of trials per time interval. Overall, more work is needed to investigate the reliability of audio-visual behavioral data.

This year’s SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule 

Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts

 

Thurs., Nov. 2: Institute for Cancer Research Seminar, 11:30 a.m., Drug Discovery (DD) Conference Room. Juhun Lee, PhD, Associate Professor of Radiology, University of Pittsburgh, will present “Advancing Breast Cancer Detection with AI: Leveraging Bilateral Asymmetry, Simulated Mammograms Using GANs, and Cautionary Considerations.”

Abstract:  Machine learning and artificial intelligence are driving forces in medical research, including radiology. These technologies heavily rely on data, often millions of meticulously curated medical images, for deep neural network development and optimization. Our lab focuses on innovative ways to maximize existing data for deep algorithm performance. In this seminar, we'll discuss recent studies from our lab. The first part explores using breast laterality features to improve breast cancer detection in mammograms through the Radon Cumulative Distribution Transform (RCDT), which can highlight subtle bilateral tissue differences in breast mammograms. We will then discuss how simulated mammograms via Generative Adversarial Networks (GANs) could improve the performance of cancer detection algorithms. I will conclude the seminar with cautions on when to use GANs for simulating mammograms, as this can significantly affect the performance of the detection algorithm.

This seminar is hosted by Purdue’s Institute for Cancer Research and the Weldon School of Biomedical Engineering.

 

Mon., Nov. 6:  Midwest Mechanics Seminar 2023, 3:30 p.m., ARMS B071. Dr. Alison Marsden, Douglass M. and Nola Leishman Professor of Cardiovascular Disease, Professor of Pediatrics and Bioengineering, and by courtesy of Mechanical Engineering, Institute for Computational and Mathematical Engineering, Stanford University, will present “Multi-physics Modeling of Flow and Cardiac Function in Pediatric Cardiology.”

Abstract: Congenital heart disease affects 1 in 100 infants and is the leading cause of infant mortality in the US. Among the most severe forms of congenital heart disease is single ventricle physiology, in which the heart develops with only one functional pumping chamber. These patients typically undergo three open chest surgeries, culminating in the Fontan procedure at three years of age. Prior work has extensively explored the use of multiscale models, combining hemodynamics with lumped parameter models of single ventricle physiology to assess surgical methods for all three stages of single ventricle palliation. Here, we present our recent work, which extends traditional models of Fontan hemodynamics to include multiple physical processes and cardiac function. We will discuss our recent progress towards: 1) growth and remodeling of tissue engineered vascular grafts in the Fontan circulation, including a finite element framework for fluid solid growth simulations, and 2) model-driven design of a bioprinted pulsatile conduit to provide a power source for Fontan physiology. Recent methodological advances for generation of vascular networks using optimization will also be described. Finally, we discuss progress and challenges of developing whole heart models incorporating machine learning for image segmentation, fluid mechanics, active contraction, electrophysiology and valves. We will describe open source software and data resources available via the SimVascular project and the Vascular Model Repository.

Bio: Alison Marsden is the Douglass M. and Nola Leishman Professor of Cardiovascular Disease in the Departments of Pediatrics, Bioengineering, and, by courtesy, Mechanical Engineering at Stanford University.  She is a member of the Institute for Mathematical and Computational Engineering. From 2007-2015 she was a faculty member in Mechanical and Aerospace Engineering at UCSD.  She graduated with a BSE degree in Mechanical Engineering from Princeton University in 1998, and a PhD in Mechanical Engineering from Stanford in 2005. She was a postdoctoral fellow at Stanford University in Bioengineering from 2005-07. She was the recipient of a Burroughs Wellcome Fund Career Award at the Scientific Interface in 2007, an NSF CAREER award in 2011. She was elected fellow of AIMBE and SIAM in 2018, the APS DFD in 2020, and BMES in 2021.  She is the 2023 recipient of the Van C. Mow medal from the ASME Bioengineering Division. She has published over 160 journal articles and holds leadership roles in the ASME and APS scientific societies. Her research focuses on the development of numerical methods for cardiovascular biomechanics and application of engineering methods to impact patient care in cardiovascular surgery and congenital heart disease.

This seminar is sponsored by Purdue’s Schools of Aeronautics and Astronautics and Mechanical Engineering.

 

Thurs., Nov. 9:  BME PhD Preliminary Exam for Grigorii Rudakov (T. Kinzer-Ursem and L. Green, co-advisors). Everyone is invited to attend the public presentation beginning at 9:00 am in MJIS 2001. For coffee and bagels come 15 minutes early. Title: DNA Tetrahedron Design Optimization for Efficient Drug Delivery Through the Blood-Brain Barrier.

Committee: Dr. Tamara Kinzer-Ursem (co-chair), Dr. Leopold Green (co-chair), Dr. Chengde Mao (Chemistry), Dr. Gregory Knipp (Pharmacy)

Abstract: In our proposed study, we aim to optimize the design of Tetrahedral DNA Nanomaterials (TDN) to effectively deliver drugs through the Blood-Brain Barrier (BBB). Starting with two classical TDN structures, we alter the design by changing the size, structure (one or two double-stranded DNA helices on the edges), and attached DNA aptamers for receptor-medicated endocytosis pathway to study the influence of these factors on cellular uptake, stability of TDNs, toxicity, and potential delivery efficiency. We plan on testing our materials in vitro HEK293, SUM159, mice cortical, and human astrocytes cellular lines, as well as in the human BBB in vitro model. To study the biodistribution and tissue toxicity, we will perform in vivo tests of the most prominent TDNs designs on the C57BL/6-wt mouse model, harvest the tissues, and run histology analysis with H&E stains. The TDNs concentration will be measured by measuring implemented into the DNA strands cyanine 3 and 5 dyes fluorescence and the stability will be estimated by Fluorescence Resonance Energy Transfer measurements. If we succeed in our work, we will develop an effective, exceptionally biocompatible, and stable nanomaterial with great potential applications in drug delivery through BBB, brain imaging, and gene therapy. We expect the main application of this nanomaterial to be in treating and mitigating the symptoms of Alzheimer's and other neurodegenerative diseases, as the low BBB permeability poses the main challenge in the way of studying and treating these illnesses.

 

Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m.  Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, the following changes to the way you use the Purdue West Lafayette telephone systems will be required.
1. Moving to utilize 10-digit dialing for all outgoing calls. This dialing method requires users to dial 1 + the area code of the person being called as part of the dialing process. However, 5-digit internal to campus dialing will remain the same.
This is a requirement dictated to use by our Carrier and is now standard nationwide. If you would like to know more about 10-digit dialing, the following website contains more information: https://www.fcc.gov/consumers/guides/ten-digit-dialing 

2. International Calling: The current process using international access codes will no longer be supported. If you currently have an international calling code and need the ability to dial internationally then please complete the form at: https://purdue.ca1.qualtrics.com/jfe/form/SV_1FVkar7IS9zKvjg 
Purdue IT strives to provide a top-quality telecommunications system and appreciates your support as we continue to upgrade our services and provide a highly reliable service. If you should have questions or concerns, please contact 
it@purdue.edu

 

Fri., Dec. 1:  Indiana Life Sciences Conference – “Closing the Gap[ of Health Inequalities,” 8:00 a.m. – 3:15 p.m., Roche Diagnostics, Indianapolis.

 




Closing the Gap of
Health Inequalities

Friday, December 1
Roche Diagnostics, Indianapolis

Addressing the persistent disparities in health and wellness among different populations is an issue that can’t be ignored. While the healthcare cost implications are significant, the societal and economic implications are even more so.

This conference will examine ongoing efforts to improve both the delivery of healthcare and health-related social factors like access to healthy foods, access to transportation and safe neighborhoods, which influence health outcomes.

 

 

AGENDA

 

8:00-9:00am

Registration & Breakfast

9:00-9:15am

Welcome & Introduction

9:15-10:15am

Opening Keynote- Defining Health Inequalities

Paul K. Halvorsen, Professor & Founding Dean, Richard M. Fairbanks School of Public Health, Indiana University

10:15-10:30am

Break

10:30am-12:00pm

Panel- Provider Perspective & Initiatives

Brownsyne Tucker Edmonds, M.D., Associate Professor of Obstetrics & Gynecology & Associate Dean for Health Equity Research, IU School of Medicine & VP Chief Health Equity Officer, IU Health

Edmond Davis, Senior Director, Health Equity, Zimmer Biomet

TBA

12:00-12:45pm

Break for Lunch

12:45-1:30pm

Luncheon Keynote- Snapshots of Ongoing Initiatives

Paige Bingham, Director, Close the Gap

Ariana McGee, Founder & CEO, Navigate Maternity

Holly Wood, Senior Director, Health Equity Initiative, Purdue University

TBA

1:30-3:00pm

Panel- Payer Perspective & Initiative

Antoniette Holt, Strategic Equity Officer & Division Director, Office of Minority Health, Indiana Department of Health

Darryl Lockett, Health Equity Director, Anthem Indiana Medicaid

Andy Vector, President of Benefits Consulting & Chief Growth Officer, MJ Insurance

TBA

3:00-3:315pm

Wrap-Up

 

 

 

 

Series Sponsors

 

 

Event Sponsors

 

 

 

 

 


Supporting Sponsors

 

Series Marketing Sponsors
Indiana Health Information Exchange
Indiana University Office of the Vice President for University Relations
Linking Pharma Women

 

 

BME Weekly Research Seminars

 

Week #

Date

Speaker

Title

Host

Website

11

11/1/2023

Ben Gaston

Billie Lou Wood Professor of Pediatrics Indiana University School of Medicine

George Wodicka

https://medicine.iu.edu/faculty/43800/gaston-benjamin

12

11/8/2023

Jean-Pierre Mobasser

Affiliate Clinical Faculty
Indiana University

Young Kim

https://www.goodmancampbell.com/our-team/team-member/jean-pierre-mobasser-md

13

11/15/2023

Jane Grande- Allen

Isabel C. Cameron Professor of Bioengineering, Rice University

Deva Chan

https://profiles.rice.edu/faculty/k-jane-grande-allen

14

11/29/2023

Sarah Wiehe

Jean and Jerry Bepko Professor of Pediatrics Indiana University School of Medicine

George Wodicka

https://medicine.iu.edu/faculty/16722/wiehe-sarah

15

12/6/2023

Robbee Wedow

Assistant Professor of Sociology and Data Science,
Purdue University Department of Sociology

David Umulis

https://www.robbeewedow.com/?_ga=2.88497945.389094989.1679581193-1816225309.1603576015

 

Postdoctoral Fellow Opportunity – IUSM Emergency Medicine

 

The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally.

For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651

 

 

Attachments

 

2024 College of Engineering Dean's Teaching Fellowship