BME
WEEKLY ROUNDTABLE
WEEK
OF November 13, 2023
INTERIM
HEAD¡¯S NOTE
Several
BME faculty won the Acorn Award recently, given to investigators in recognition of their accomplishment in obtaining an external sponsored award of $1 million or more. Please see lists of awardees by year. To find out who they are, please visit
https://www.purdue.edu/research/oevprp/researcher-resources/awards/seed-for-success/
Congratulations!
We
are coming down the home stretch. Everyone, please take care and please be mindful of the changes and development among students you teach when you interact with them.
We
have gotten additional clarity on the staff side of our academic unit on the PU – Indy campus. We are approved to have one academic advisor, one administrative assistant, one research lab operations person, and one instructional lab operations person. Vitaliy
and I are collecting information from the teaching faculty there to clarify the job responsibilities of the instructional lab operations person. We hope to have sufficient clarity by our next faculty meeting.
The
Bilsland Dissertation Fellowship
is a wonderful way to recognize our graduate students. as they get ready to finish up their PhD research. More information is in the Graduate Program Update section.
UPCOMING
IMPORTANT DATES
Week
of November 13
Mon.,
Nov. 13: Center
for Diabetes and Metabolic Diseases Research Seminar Series/Diabetes Day,
12:00
p.m., R4-101 (Indianapolis) and via Zoom. Susan Bonner-Weir, PhD, Diabetes Research and Wellness Foundation Professor, Joslin Diabetes Center and Professor of Medicine, Harvard Medical School will present ¡°Evidence of (Re)growth of Human Endocrine Pancreas?¡±
This seminar is hosted by the IU School of Medicine and the Center for Diabetes and Metabolic Diseases.¡± Zoom link:
https://iu.zoom.us/s/87501979533
Wed.,
Nov. 15: Weldon
School of Biomedical Engineering Research Seminar,
9:30
a.m., MJIS 1001 or via Zoom. Jane Grande-Allen, PhD, Department of Bioengineering, Rice University, will present ¡°Biophysically Faithful Biomaterial Platforms for Cardiovascular and Intestinal Mechanobiology.¡±
Wed.,
Nov. 15, Advancing
Discovery in Antimicrobial Resistance Seminar Series, 12:00
noon, Purdue DRUG, Lobby Conference Room. Dr. Christopher A. Rice, Assistant Professor of Parasitology, Section Head, Microbiology, Immunology and Molecular Genetics, Member of PIDD, PI4D and RCHE, Department of Comparative Pathobiology will present ¡°Awareness,
Drug Discovery, and Diagnostic Tools for Pathogenic Free-Living Amoebae.¡± The seminars are sponsored by the College of Veterinary Medicine, Department of Basic Medical Sciences.
Thurs.,
Nov. 16: BME
PhD Preliminary Exam Announcement for Elnaz Ghajar-Rahimi,
(C.
Goergen, advisor), 2:30 p.m., MJIS 2001 and via Zoom. Title: Cardiovascular remodeling due to volume and pressure overload.
Thurs.,
Nov. 16:
Seminars
in Hearing Research,
12:00 noon, Nelson Hall, Room 1215. Andrew Sivaprakasam, MD/PhD Trainee, Indiana University School of Medicine will present ¡°Physiological and Perceptual Investigations of Place and Time Coding of Pitch Across Species: Preliminary Findings and Experimental
Framework.¡±
Fri.,
Nov. 17: BME
PhD Preliminary Exam Announcement for Eugene S. Kim
(T. Kinzer-Ursem, advisor).
Everyone is invited to attend the public presentation beginning at 1:00 p.m. in MRGN 121. Title: ¡°The Role of CaMKII¥â-DrebrinA Binding in F-actin Stabilization in Dendritic Spines.¡±
Fri.,
Nov. 17: BME
PhD Defense Announcement for Tyler Diorio
(V. Rayz, advisor). Everyone is invited to attend the public presentation beginning at 3:30pm in MJIS 2001 and via Zoom.
Title of Thesis Research: Brain Biomechanics: Multiscale Mechanical Changes in the Brain and its Constituents.
As
of Wed., Nov. 29: Telephone
System Update Implemented,
7:00
p.m. Purdue
IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required, including required use
of area codes for ALL calls. See link below for details.
ACADEMIC
PROGRAMS ALERT
Re:
final exam accommodations. We have a number of students who may need accommodations for final exams and faculty need to be proactive in scheduling with the Testing Center if they plan to use that.
Below
is some important information instructors should know if they choose to have Purdue Testing Services (PTS) administer their accommodated exams.
*If
you had already submitted a TIF for your final prior to receiving this email, PTS staff updated your TIF to the correct exam group
Another email will be sent closer to finals week with more important information regarding delivery and return methods. Instructors may find up-to-date information as well as step-by-step guides on
our
website.
Thanks,
Kelsey
Jordan, M.S.
she/her/hers
Director, Purdue
Testing Services
ALSO:
We
are now more than halfway through the Fall term so here are some reminders as we round the corner to final grading:
FERPA,
GLBA, Protecting SSNs, and Data Handling all must be current at the time of grade entry to prevent any roadblocks.
https://www.purdue.edu/registrar/faculty/grading/index.html
Full
Term (16 Weeks) and Second Eight-Week Session (meeting between October 18 and December 16)
Grade
entry begins at 8 a.m. December 1 and ends at 5 p.m. December 19.
GRADUATE
PROGRAM UPDATE
Fellowship
Opportunity
The
Bilsland Dissertation Fellowship
provides support for outstanding PhD candidates in their
final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details
https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff/index.html
Note:
Students in other schools outside of BME should follow those schools¡¯ procedures.
Due
Date: Sunday, December 3rd (tsiemers@purdue.edu)
Student
Eligibility
Application
Package Should Include the following in one PDF:
Salary
& Usage:
The
announcement will go out to the students as well. Please let me know if you have any questions.
Excellence
in Teaching Awards Competition
Applications
are now being accepted for the Midwestern Association of Graduate Schools (MAGS) 2024 Excellence in Teaching Awards Competition. The University is eligible
to nominate one masters-level and one Ph.D.-level student for each award that includes a citation and a $750 honorarium that will be presented at the MAGS annual meeting on April 3-5, 2024. Interested students must submit their application materials to the
Graduate School by Friday, December 1, 2023, at 5:00 p.m. for consideration.
Award
Details
Submission
Details
Graduate
students wishing to be considered for this award must submit a single PDF document that includes:
Timeline
toward nomination
Questions?
Please
contact Associate Dean David Rollock at the Graduate School (rollock@purdue.edu;
496-2775).
Upcoming
important deadlines and information
Wed.,
Nov. 29: Seminar
for Neurotrauma and Diseases, 4:00
p.m., DLR 131. Koji Uchida, Professor of Food Chemistry, University of Tokyo will present ¡°Conversion of Proteins into DNA Mimetics by Reactive Aldehydes.¡± This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue
Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is:
https://bit.ly/441Dllq.
For additional information, see https://vet.purdue.edu/cpr/
Wed.,
Nov. 29: Telephone
System Update Implemented,
7:00
p.m. Purdue
IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required. See link below for details.
Fri.,
Dec. 1: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate
Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Fri.,
Dec. 1: Indiana
Life Sciences Conference – ¡°Closing the Gap[ of Health Inequalities,¡± 8:00
a.m. – 3:15 p.m., Roche Diagnostics, Indianapolis. See below for details.
Sun.,
Dec. 3: The Bilsland Dissertation Fellowship nominations
due to Tammy Siemers (tsiemers@purdue.edu).
See above for details.
Thurs.,
Dec. 14: SAVE
THE DATE: 2023 Senior Design Projects Expo and Awards Ceremony, 3:30-5:30
p.m., MJIS. Please mark your calendars and plan to join us to celebrate the achievements of our 2023 senior design teams. The expo will highlight 30 innovative engineering solutions, followed by a live awards ceremony.
Fri.,
March 1: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate
Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Fri.,
June 7: Indiana
Human-Centered Design for Health Seminar Series, 12:00
p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor,
Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar
Resources
and further information
Wed.,
Nov. 15: Weldon
School of Biomedical Engineering Research Seminar,
9:30
a.m., MJIS 1001 or via Zoom. Jane Grande-Allen, PhD, Department of Bioengineering, Rice University, will present ¡°Biophysically Faithful Biomaterial Platforms for Cardiovascular and Intestinal Mechanobiology.¡±
Abstract:
The material behavior of many biological tissues is due to their unique microstructural arrangements of fibrous extracellular matrix (ECM) proteins, i.e., collagen and elastin, within the more amorphous matrix. The orientation of these fibers, and their segregation
into discrete regions within the tissues, often gives rise to anisotropy and unique biological stress-strain behavior that enables the essential function of the tissues. Layered or segregated structuring allow hierarchical tissue organization in a manner designed
to withstand external forces efficiently while protecting more delicate tissues and cells from damage. These structure-function relationships within biological tissues have been studied for decades but have not been widely translated into the creation of biomimetic
scaffolds for use in tissue engineering and in vitro analyses of cell and tissue biology. The Grande-Allen research group has focused on integrating these structural and material characteristics into hydrogel and fibrous biomaterials using a range of fabrication
techniques including molding, photolithography, electrospinning, and 3D printing. The majority of our investigations have addressed heart valve disease, which is widely prevalent in our society, with valve replacement or repair in almost 100,000 people in
the United States and 275,000 people worldwide each year. More recently, we have translated our fabrication strategies to generate biomaterial platforms for investigating intestinal epithelial cell biology and enteric diseases.
Biography:
Jane Grande-Allen is the Isabel Cameron Professor of Bioengineering at Rice University. Her research group investigates the structure-function-environment relationship of soft connective tissues through bioengineering analyses of the extracellular matrix
and cell mechanobiology, with a focus on cardiovascular and intestinal diseases, as described in >180 peer-reviewed publications. Dr. Grande-Allen received a BA in Mathematics and Biology from Transylvania University in 1991 and a PhD in Bioengineering from
the University of Washington in 1998. After postdoctoral research in Biomedical Engineering at the Cleveland Clinic, she joined Rice University in 2003 and was promoted to full professor in 2013. Dr. Grande-Allen is a Fellow of AIMBE, IAMBE, BMES, AAAS, AHA,
and the Society for Experimental Mechanics. She served on the BMES Board of Directors and Executive Board from 2009-2022 and was BMES Secretary from 2020-2022. Dr. Grande-Allen also serves on the research committee for the American Heart Association.
~
BME
Host: Deva Chan ~
NOTE:
Students
registered for the seminar are expected to attend in-person.
Zoom
link:
https://purdue-edu.zoom.us/j/95124789878?pwd=S0x0VW5Vd3VaMVc1LytlL0NJU1FYUT09
Thurs.,
Nov. 16: BME
PhD Preliminary Exam Announcement for Elnaz Ghajar-Rahimi,
(C.
Goergen, advisor), 2:30 p.m., MJIS 2001 and via Zoom. Title: Cardiovascular remodeling due to volume and pressure overload.
Advisory
Committee: Craig J. Goergen, Chair; Vitaliy L. Rayz; Fiona R. Kolbinger; Kyoko Yoshida; Benjamin J. Landis
Abstract:
Volume and pressure overload induce cardiac remodeling that may lead to heart failure when left untreated. Conditions such as pregnancy, lactation, and aortic stenosis are common etiologies of pressure and volume overload. However, sex- and female-specific
variables and recovery are often overlooked in studies of cardiac overload. One of the most common modalities used to study cardiac function, 2D ultrasound, does not fully capture changes that may occur to heart shape and performance given that it is limited
to a single imaging plane. To improve our understanding of pressure and volume overload we propose mouse models of lactation, chronic hypertension with pregnancy, and reversible transverse aortic constriction. We hypothesize that four-dimensional ultrasound
will reveal the unique ways in which volume and pressure overload in the setting of pregnancy, lactation, and aortic constriction affect cardiac remodeling. Completion of this study will broaden the horizons of maternal cardiac health and lay the framework
for future exploration of sex as a biological variable in CVD studies.
Zoom
link: https://purdue-edu.zoom.us/j/94088456640
Thurs.,
Nov. 16: Seminars
in Hearing Research,
12:00 noon, Nelson Hall, Room 1215. Andrew Sivaprakasam, MD/PhD Trainee, Indiana University School of Medicine will present ¡°Physiological and Perceptual Investigations of Place and Time Coding of Pitch Across Species: Preliminary Findings and Experimental
Framework.¡±
Abstract: An
elusive empirical neural explanation for pitch perception has inspired several cochlear place and time-dependent hypotheses. Most experts debate the importance of tonotopy versus temporal coding, but it is still unclear how disruptions of these mechanisms
are influenced by sensorineural hearing loss (SNHL). SNHL is complex, but as a diagnosis, it groups variable degrees of inner and outer hair cell (IHC/OHC) and cochlear synapse (CS) damage which likely results in different patterns of pitch perception. With
careful stimulus design and electrophysiological data harmonization between animal and human subjects, we are developing a framework to more directly link alterations in neural coding to pitch perceptual outcomes. I will present progress related to my NRSA
F30 project (Title: Place and Time Processing of Pitch in the Context of Cochlear Dysfunction), which was funded thanks to the fruitful discussions and feedback sparked by this seminar two years ago. Key progress so far includes data collection in several
chinchillas and humans with normal hearing status, involving iteratively refined electrophysiological (EFR, ACC) and behavioral correlates (F0DL) of place and time coding.
This
year¡¯s SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule
Titles
and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts
Fri.,
Nov. 17: BME PhD Preliminary Exam Announcement for Eugene S. Kim
(T. Kinzer-Ursem, advisor).
Everyone is invited to attend the public presentation beginning at 1:00 p.m. in MRGN 121. Title: ¡°The Role of CaMKII¥â-DrebrinA Binding in F-actin Stabilization in Dendritic Spines.¡±
Thesis
Committee members: Dr. Tamara L. Kinzer-Ursem (Chair), Dr. Janice P. Evans, Dr. Fang Huang, Dr. Krishna Jayant
Abstract:
Alzheimer¡¯s disease (AD) is a neurodegenerative disease often observed in elderly patients (¡Ã65y/o). Symptoms of AD include, but are not limited to, loss of learning and memory function and epileptic seizures. Symptoms of AD are rooted in dysfunctional synapses
between neurons, leading to impaired synaptic plasticity. Several genes are associated with AD. For example, mutations in the gene encoding drebrin (DBN) are strongly implicated in AD. Drebrin1A (DBN1A) is an actin-stabilizing protein prominently expressed
in dendritic spines and helps maintain the cytoskeletal structure. The role of DBN1A in structure-based synaptic plasticity has not been described. Dendritic spines are protrusions on the postsynaptic neuron and are composed of a spine head and spine neck.
Although spine head enlargement is commonly seen in synaptic plasticity, an understanding of how the regions between the spine neck, head-neck interface, and spine head are regulated and its relation to synaptic plasticity is lacking. A recent discovery of
DBN1A and CaMKII¥â interactions near this interface has been reported. However, it is still unclear how CaMKII¥â-DBN1A increases F-actin bundling in dendritic spines. Based on the literature, we suspect that CaMKII¥â-DBN1A binding plays a significant role in
structure-based synaptic plasticity. We hypothesize that during synaptic plasticity, structural remodeling of dendritic spines requires CaMKII¥â-DBN1A to stabilize the F-actin pool at the head-neck interface. To test this hypothesis, we propose to use super-resolution
microscopy (SRM) and molecular dynamic (MD) simulations to provide comprehensive evidence that CaMKII¥â-DBN1A complex is critical F-actin bundling during synaptic plasticity in dendritic spines.
Fri.,
Nov. 17: BME PhD Defense Announcement for Tyler Diorio
(V. Rayz, advisor). Everyone is invited to attend the public presentation beginning at 3:30pm in MJIS 2001 and via Zoom.
Title of Thesis Research: Brain Biomechanics: Multiscale Mechanical Changes in the Brain and its Constituents.
Thesis
Committee: Dr. Vitaliy Rayz (Chair), Dr. Yunjie Tong, Dr. Deva Chan, and Dr. Eric Nauman (School of Biomedical Engineering, University of Cincinnati, OH)
Abstract:
The brain is a dynamic tissue that is passively driven by a combination of the cardiac cycle, respiration, and slow wave oscillations. The function of the brain relies on its ability to maintain a normal homeostatic balance between its mechanical environment
and metabolic demands, which can be greatly altered in the cases of neurodegeneration or traumatic brain injury. It has been a challenge in the field to quantify the dynamics of the macroscale tissue and cerebrospinal fluid flow in human subjects on a patient-specific
basis over the many spatial and temporal scales that it relies upon. Non-invasive imaging tools like structural, functional, and dynamic MRI sequences provide modern researchers with an unprecedented view into the human brain. Our work leverages these sequences
by developing novel, open-source pipelines to 1) quantify the biomechanical environment of the brain tissue over 133 functional brain regions, and 2) estimate real-time cerebrospinal fluid velocity from the noise on functional MRI by employing breathing regimens
to enhance fluid motion. These pipelines provide a comprehensive view of the macroscale tissue and fluid motion in a given patient. Additionally, we sought to understand how the transmission of macroscale forces, in the context of traumatic brain injury, contribute
to neuronal damage by 3) developing a digital twin to simulate 30-200 g-force loading of 2D neuronal cultures and observing the morphological and electrophysiological consequences of these impacts in vitro by our collaborators. Taken together, we believe these
works are a steppingstone that will enable future researchers to deeply understand the mechanical contributions that underly clinical neurological outcomes and perhaps lead to the development of earlier diagnostics, which is of dire need in the case of neurodegenerative
diseases.
Zoom
link: https://purdue-edu.zoom.us/j/98326783717
Wed.,
Nov. 29: Telephone
System Update Implemented,
7:00
p.m. Purdue
IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, the following changes to the way you use the Purdue West Lafayette telephone systems will be required.
1. Moving to utilize 10-digit dialing for all outgoing calls. This dialing method requires users to dial 1 + the area code of the person being called as part of the dialing process. However, 5-digit internal to campus dialing will remain the same.
This
is a requirement dictated to use by our Carrier and is now standard nationwide. If you would like to know more about 10-digit dialing, the following website contains more information: https://www.fcc.gov/consumers/guides/ten-digit-dialing
2.
International Calling: The current process using international access codes will no longer be supported. If you currently have an international calling code and need the ability to dial internationally then please complete the form at: https://purdue.ca1.qualtrics.com/jfe/form/SV_1FVkar7IS9zKvjg
Purdue IT strives to provide a top-quality telecommunications system and appreciates your support as we continue to upgrade our services and provide a highly reliable service. If you should have questions or concerns, please contact it@purdue.edu.
Fri.,
Dec. 1: Indiana
Life Sciences Conference – ¡°Closing the Gap[ of Health Inequalities,¡± 8:00
a.m. – 3:15 p.m., Roche Diagnostics, Indianapolis.
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|

BME
Weekly Research Seminars
|
Week
# |
Date |
Speaker |
Title |
Host |
Website |
|
13 |
11/15/2023 |
Jane
Grande- Allen |
Isabel
C. Cameron Professor of Bioengineering, Rice University |
Deva
Chan |
|
|
14 |
11/29/2023 |
Sarah
Wiehe |
Jean
and Jerry Bepko Professor of Pediatrics Indiana University School of Medicine |
George
Wodicka |
|
|
15 |
12/6/2023 |
Robbee
Wedow |
Assistant
Professor of Sociology and Data Science, |
David
Umulis |
https://www.robbeewedow.com/?_ga=2.88497945.389094989.1679581193-1816225309.1603576015 |
Postdoctoral
Fellow Opportunity – IUSM Emergency Medicine
The
laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical
and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores
highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is
to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary
research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include:
(1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like
fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of
environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally.
For
additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651