BME Summer Seminar Series

Wednesday, June 1^st, 2022

9:30-10:30AM EST

Via Zoom Meeting – link below*

Evaluation links:

Hammad Khan: https://purdue.ca1.qualtrics.com/jfe/form/SV_7TEqpoFmC1So8cu

Vidhya Vijayakrishnan Nair: https://purdue.ca1.qualtrics.com/jfe/form/SV_5bUJg6ukLwsXsxg

Speaker 1: Title: TBD

Hammad Khan (K. Jayant / T. Kinzer-Ursem, advisor)

Speaker 2: Human CSF Movement Influenced by Vascular Low-Frequency Oscillations and Respiration

Vidhya Vijayakrishnan Nair (Y. Tong, advisor)

Abstract:

The flow of Cerebrospinal fluid (CSF) through the pathways within the central nervous system is of high significance for maintaining normal brain health and function. Nevertheless, the exact driving forces behind CSF flow are still poorly understood. Low-frequency hemodynamic oscillations and respiration are two important mechanisms that have been shown to drive CSF in the brain. This study explores their independent and coupled effects on CSF movement using novel functional MRI scans of the neck. The results show that the CSF movement can be assessed from the neck by studying the interactions between the oscillations of blood and CSF from large blood vessels and ventricles, respectively. Furthermore, a cross-frequency interaction between the two separable mechanisms was also revealed. This capability of the CSF system to respond to multiple physiological forces simultaneously would help unveil the pathological mechanisms behind CSF flow-related disorders and facilitate the development of new therapeutic interventions. Moreover, the simple fMRI method employed here could be used to assess these CSF-related disorders.

*Join Zoom Meeting

https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz09

Meeting ID: 921 6873 9019

Passcode: biomedical

Elizabeth Rowen

She/Her

Graduate Program Assistant
Weldon School of Biomedical Engineering

Martin C. Jischke Hall of Biomedical Engineering
206 S. Martin Jischke Drive
West Lafayette, IN 47907-2032

o: 765-494-1197