I would like to bring to your attention a seminar by Ms. Taylor Baum from MIT.
Title:
Adaptive Closed-Loop Control of Arterial Blood Pressure with Phenylephrine and Clevidipine
Date/time:
Thursday, March 12, 3:30 pm - 4:30 pm
Abstract: Poor regulation of arterial blood pressure (ABP) in the operating room or intensive care unit is associated with increased morbidity
and mortality. Although closed-loop ABP control has been pursued for decades, clinical adoption has remained extremely limited. In this work, we present a novel bidirectional adaptive closed-loop ABP control system. Our system comprises two adaptive model
predictive controllers: one actuated by phenylephrine (PE) and the other by clevidipine (CL). Through validation experiments in swine, we find that, in non-emergent, post-transient periods, our PE-actuated controller maintained mean ABP within +/- 5 mmHg of
the target 99.4% of the time (95% CI: 98.4, 100.0) and has 1.0 mmHg (95% CI: 0.8, 1.4) mean absolute error (MAE) and our CL-controller, 95.4% (95% CI: 90.8, 98.7) with 1.6 mmHg (95% CI: 1.1, 2.1) MAE. We additionally find that both controllers rapidly rejected
severe disturbances, and that mid-session switching between controllers was achieved safely. These results demonstrate the attainable precision and stability of bidirectional adaptive closed-loop ABP control and support its potential for clinical translation.
Bio: Taylor Elise Baum is an Electrical Engineering and Computer Science PhD Candidate at the Massachusetts Institute of Technology (MIT),
advised by Profs. Emery Brown, Munther Dahleh and Thomas Heldt. She is interested in improving how we understand and control physiological systems (e.g., the cardiovascular system and nervous system) in the OR and ICU. Her PhD work has advanced systems that
automate cardiovascular management, including arterial blood pressure regulation and treatment of serious cardiac arrhythmias. Taylor’s research has recently been recognized with a featured article in IEEE Transactions on Biomedical Engineering (2024), an
invited article at the American Control Conference (2025), the Hugh Hampton Young Memorial Fund Fellowship (2024) and selection as a Rising Star in EECS (2025) as well as an MIT Graduate Woman of Excellence (2023). She also founded Sprouting Education, which
develops bilingual curricula and has hosted 30+ events across South America and the U.S., earning her MIT’s Seth J. Teller Award for Excellence, Inclusion and Diversity (2023).