BME
Monday ROUNDTABLE
July
3, 2023
INTERIM
HEAD’S NOTE
I
am starting this new position as Interim Head in the Weldon School of Biomedical Engineering at Purdue University. I am humbled to continue to have the wonderful opportunity to serve the Weldon School, its faculty, staff, and students. I hope to serve all
of you better in the coming academic year in this role.
UPCOMING
IMPORTANT DATES
Week
of July 3
Tues.,
July 4: Official University Holiday. All
offices and buildings closed.
Wed.,
July 5: BME
Summer Seminar,
9:30
a.m., via Zoom. Grigorii Rudakov (Tamara Kinzer-Ursem/Leopold Green, advisors) will present “Drug Delivery Through Blood-Brain Barrier: DNA Nano Lego for Grown-Ups” and Ankit Shah (Hugh Lee, advisor) will present “Advancing Smart Catheter Technology: Development
of a 4-Axis 3D Printer for Direct Printing of Electronics on Curvilinear Surfaces.”
Thurs.,
July 6: BME
Master’s Defense Announcement
for
Zada B. Anderson (B. Duerstock and Thomas H. Everett IV,
co-chairs), 2:00 p.m., via Zoom. Title of presentation: Cardiac Effects of Recurring Autonomic Dysreflexia.
MJIS
UPDATES
Just
a reminder: If you eat/snack in any of the seating areas in MJIS, please take a moment when you are finished to spray and wipe down the tables and make sure all trash is in the trash bins. We are seeing quite an infestation of ants that are attracted to food
residue and crumbs! There are cleaning supplies available in each area. PLEASE remember to clean up after yourself each time.
Also,
we are seeing a lot of backpacks, bookbags and personal items being left in the sitting areas. The Purdue Police have notified us that the theft ring has made a reappearance on campus, and are working their way through campus building. This particular group
works on a “theft by convenience” mode – entering unlocked offices, and taking whatever is readily available. If you have high school students or others working in your labs this summer, please make sure they keep their personal belongings on the provided
hooks inside the secure lab block. Don’t allow yourself to be the victim of a convenience crime!
Important
deadlines and information
Tues.,
July 11: BME IBSC PhD Defense Announcement for Mazin Hakim (L. Solorio, advisor),
3:00 p.m., MJIS 2001 and via Zoom. This defense is open only to those who have signed the Lilly NDA.
Title: Platforms for Molecular Mechanisms and Improvement in Subcutaneous Injection of Biotherapeutics.
Advisory Committee: Luis Solorio, Chair; Arezoo M. Ardekani; Julie C. Liu; Pavlos P. Vlachos.
Join
Zoom Meeting
https://purdue-edu.zoom.us/j/94670872770?pwd=SmxaZjFlaSs3RXVPZWZsU3d3SXhsQT09
Meeting ID: 946 7087 2770
Passcode: Mazin
Sat.
July 15th:
Nominations submitted from faculty and staff for
Purdue Engineering Fellows. The Purdue
Engineering
Fellows program is designed to recognize the accomplishments, contributions and potential of seven
outstanding seniors who make a difference in the college and in the lives of others by
bringing creative thinking to their academic activities, demonstrating distinctive
problem-solving abilities, and are respected by their peers and faculty. In summary,
Purdue
Engineering Fellows will be students who demonstrate impressive abilities to think creatively and to develop innovative solutions to problems—whether in the classroom, in student life, or
in the community. We are now asking our faculty and staff to submit nominations through the Qualtrics survey:
https://purdue.ca1.qualtrics.com/jfe/form/SV_7ZZLY4ioCfXwjb0
by July 15th.
Students
must be in their senior year and graduating in May of 2024 (December grads are not eligible). Upon graduation,
each recipient will receive $20,000 to use as they see fit. A nomination
letter and copy of the student’s resume are required for full consideration.
Contact Darshini Render (render@purdue.edu) if you have questions, including verifying your student nominee eligibility. You can find information about previous Purdue Engineering Fellows here:
https://engineering.purdue.edu/Engr/AboutUs/News/Spotlights/2022/2022-0923-purdue-engineering-fellows
Mon.,
July 24: Final Grade Entry Begins. (Ends
promptly at 5:00 p.m., Tues., August 8th).
Wed.,
Sept. 6: BMES
Early Bird Registration Deadline! Register
now to lock in savings with early-bird pricing for the 2023 BMES Annual Meeting (to be held in Seattle, WA, October 11-14). Thousands of biomedical engineers will attend this year’s meeting to learn, collaborate, and network. As a BMES member, you can save
more than 10% with reduced early bird rates, so if you’re not already a member, now would be a good time to join! Click here for details:
https://mailchi.mp/e3958bb463f2/o8cvhb9q5x-9335625?e=ea10e317a2
NOTE:
We recommend booking your room at the Hyatt Regency Seattle because it’s
closer to the convention center AND it’s where university receptions will be held (in addition to some being held
inside the convention center). Here’s the link to reserve with the $259 discount rate.
This rate only lasts until the allotted number of rooms have been sold.
https://www.hyatt.com/en-US/group-booking/SEARS/G-BMES
Fri.,
Sept. 8: Abstract
Submission Deadline for The Trauma THOMPSON Challenge.
The
primary goal of The Trauma THOMPSON Challenge is to encourage research to build better algorithms for autonomous instruction systems in uncontrolled and austere environments, especially for life-saving procedures. The envisioned algorithms include action recognition,
action anticipation, procedure recognition, and visual question answering (VQA). The challenge participation details are below.
Committee
Updates
Academic
Programs Update
Summer
Grading Deadlines:
-
Final
Grading windows are found here:
-
Full
12-week summer session (includes
all undergrad and grad-level research students)
-
Grade
entry begins at 8 a.m. Monday July 24th and ends promptly at 5 p.m. Tuesday August 8th.
-
Guidance
on Final grading -
Now
is the perfect time for faculty to take the 15 minutes to get all your required certifications up to date BEFORE the deadline approaches.
- FERPA
- GLBA
- Data
Handling
-
Protecting
SSNs
- This
page
provides myPurdue grade entry instructions.
- This
page
provides BrightSpace final grade submission instructions.
- Those
not making the deadline must use the Grade Change Workflow to submit a grade for each student.
- Instructions
may be found here.
Resources
and further information
BME Summer Seminar,
Wed., July 5,
9:30 a.m., via Zoom. Grigorii Rudakov (Tamara Kinzer-Ursem/Leopold Green, advisors) will present “Drug Delivery Through Blood-Brain Barrier: DNA Nano Lego for Grown-Ups” and Ankit Shah (Hugh Lee, advisor)
will present “Advancing Smart Catheter Technology: Development of a 4-Axis 3D Printer for Direct Printing of Electronics on Curvilinear Surfaces.”
*Join Zoom Meeting
https://purdue-edu.zoom.us/j/98231659969?pwd=T21Oa1B6QzFyQzFvckMzS1doNGlJUT09
Meeting ID: 982 3165 9969,
Passcode: biomedical
Drug Delivery Through Blood-Brain Barrier: DNA Nano Lego for Grown-Ups
Abstract:
Treating brain-related diseases non-invasively poses a significant challenge, primarily due to the highly impermeable nature of the Blood-Brain Barrier (BBB). The BBB acts as a filter, preventing the passage of most artificial materials larger than 100 nm.
Additionally, the substantial proton gradient between the brain and blood flow further complicates drug delivery. However, the field of nanomaterials offers promising solutions to overcome these obstacles, thanks to their small sizes and extensive research
spanning over 50 years. Numerous approaches and materials have been investigated to enhance BBB permeability, including polymeric, organic, and inorganic nanoparticles, as well as composite nanomaterials. Despite these efforts, achieving efficient drug transport
through the BBB remains a significant challenge. In this study, we focus on utilizing DNA nanomaterials, known for their exceptional biocompatibility, to facilitate the delivery of dyes into the brain. Specifically, we employ DNA tetrahedra, which are extensively
studied and possess excellent physical rigidity. Our research investigates the impact of various factors, such as size, structure, receptor-mediated endocytosis pathway, and DNA chirality, on the efficiency of drug delivery. Our ultimate goal is to optimize
this approach and achieve maximum delivery efficiency while ensuring high biocompatibility. To assess efficiency, we consider factors such as stability (both biological and physical), toxicity, and the quantity of dye delivered through both passive and active
diffusion. The outcomes of this study hold significant potential. Firstly, we aim to gain insights into the most efficient method of drug delivery through the BBB using the most biocompatible material available. Additionally, our research contributes to the
advancement of DNA bionanotechnology, paving the way for further developments in this field. Ultimately, our work represents a crucial milestone towards effectively treating brain-related diseases by enabling efficient drug delivery to the brain. This text
was edited with chatGPT.
Evaluation link for Grigorii Rudakov:
https://purdue.ca1.qualtrics.com/jfe/form/SV_2rjC90vn9ZYFw0K
Advancing Smart Catheter Technology: Development of a 4-Axis 3D Printer for Direct Printing of Electronics on Curvilinear Surfaces
Abstract: The demand for flexible conformal electronics on curvilinear surfaces for health monitoring and therapeutic applications has emerged due to the curvilinear nature of human
anatomy. This research focuses on developing a 4-axis 3D printer designed specifically to address challenges associated with the conformal manufacturing of electronics on catheter surfaces for smart catheter applications. The goal is to eliminate complex lithography
transfer techniques and overcome issues related to adhesion, surface geometry mismatch, material wastage, and other common problems in traditional fabrication methods. The key innovation of this device is its ability to directly print electronics on the catheter
surface, transforming the catheter into a print bed. Leveraging the catheter's rotational movement and automatic height detection with specialized control system algorithms, the printer ensures precise nozzle positioning regardless of the catheter's surface
geometry. Directly printing electronics onto catheters enables the development of advanced functionalities, including integrated sensors, wireless communication modules, and therapeutic devices. Additive manufacturing and the versatility of different inks
and nanomaterials allow for incorporating a wide range of functionalities into these conformal medical devices. We have demonstrated printing encrypted chipless RFID antennas, microheaters, flow sensors, pH sensors, strain sensors, and flexible conducting
traces directly on catheters, unlocking the potential for smart implantable catheters. This advancement enhances monitoring, diagnostics, and treatment capabilities while reducing the complexity and costs associated with traditional manufacturing techniques.
The 4-axis printing approach provides customization and adaptability, allowing for patient-specific and tailored electronic devices on catheters.
Evaluation link for Ankit Shah:
https://purdue.ca1.qualtrics.com/jfe/form/SV_8GrFpXuRHzrgy2O
BME Master’s Defense Announcement
for Zada B. Anderson (B. Duerstock and Thomas H. Everett IV, co-advisors),
Thurs., July 6, 2:00 p.m., via Zoom. Title of presentation: Cardiac Effects of Recurring Autonomic Dysreflexia.
Advisory Committee: Bradley S. Duerstock and Thomas H. Everett IV, co-chairs, Riyi Shi
Abstract: Persons with a spinal cord injury (SCI) above the sixth thoracic vertebrae commonly experience autonomic dysreflexia (AD), 90 percent of individuals with this level of injury are
susceptible to AD which is associated with an increase in sympathetic nerve activity. Left untreated AD causes a paroxysmal rise in blood pressure that may result in seizures, heart attack, or even death. This project investigates how AD affects QT interval,
RR interval, P wave height, heart rate, and QRS width both during an event and long term to help identify potential cardiac risks for individuals with SCI who experience chronic AD. Sympathetic tone has been shown to influence QT interval changes that can
be indicative of an increased risk of arrhythmia, which can be exacerbated by recurring episodes of AD. A rat spinal cord injury model at the T3 level undergoing colorectal distention (CRD) was used to induce AD. Electrophysiological recordings from an implanted
ECG sensor and noninvasive skin nerve activity (SKNA) sensor array during normal baseline and three trials of CRD were collected on days 5, 7, 9, 11, 14, 16, 19, and 21 post-SCI. QT interval measurements were taken for 2 minutes of baseline and for 2 minutes
after the initiation of each CRD trial. Corrected QT interval (QTc) was calculated using normalized Bazett’s formula to account for the impact of heart rate
on QT interval. It was found that the rats’ susceptibility and reaction to AD events varied between subacute (5-14 days) and chronic phases of SCI. During the chronic phase the incidence of AD events increased during regular occurrences of CRD as indicated
by above-threshold (≥15 mmHg) blood pressure spikes. AD events also resulted in increased QT interval short term variability marking an increased risk of arrythmias. Baseline P-wave height and QTc interval were also increased resulting in potentially detrimental
cardiac effects. This rat model showed that humans who experience recurrent AD during the chronic phase of SCI may be at increased risk for arrythmia.
Location:
Zoom - https://purdue-edu.zoom.us/j/93427795215
Fri., Sept. 8: Abstract Submission Deadline for The Trauma THOMPSON Challenge.
The primary goal of The Trauma THOMPSON Challenge is to encourage research to build better algorithms for autonomous instruction systems in uncontrolled and austere environments, especially for life-saving procedures. The
envisioned algorithms include action recognition, action anticipation, procedure recognition, and visual question answering (VQA). The challenge participation details are below.
We cordially welcome and invite you to take part in The Trauma THOMPSON Challenge at MICCAI 2023, which will be held in Vancouver, BC on October 12, 2023.
*****************************************************************
Event: The Trauma THOMPSON Challenge
Location: Co-located with MICCAI 2023 (Satellite Event)
Date: October 12, 2023
TIME: AM Session
Abstract Submission Deadline:
September 8th, 2023
Paper Submission Deadline:
September 15th, 2023
Challenge Website: https://thompson-challenge.grand-challenge.org
*****************************************************************
Challenge Overview:
The primary goal of The Trauma THOMPSON Challenge is to encourage research to build better algorithms for autonomous instruction systems in uncontrolled and austere environments, especially for life-saving procedures. An AI-based guidance
system does not only enhance the capabilities of untrained personnel to deliver diagnosis or resuscitative care in austere environments but also increases their confidence to undertake psychologically daunting procedures. This dataset would allow the study
of human actions and intentions from the first-person view in the medical domain (refer to egocentric datasets of medical procedures). To the best of our knowledge, our dataset is the first egocentric view dataset of life-saving intervention (LSI) procedures
with detailed annotations by medical professionals. We have collected over 200 procedure videos with environment, simulator, and type variability. Based on this dataset, the challenge we propose involves multiple tasks to encourage participants across the
globe to design impactful algorithms with applications to medicine. The envisioned algorithms include action recognition, action anticipation, procedure recognition, and visual question answering (VQA). The challenge participation details are available on
our challenge
website.
Call for Participation and Papers:
There will be 2 tracks for this challenge and a total of 4 challenge tasks. All accepted papers will be included in the MICCAI challenge proceedings (Lecture Notes in Computer Science (LNCS) volume in the challenges subline). We have
a leaderboard for each task and submitting a paper (min 6 pages, max 12 pages, LNCS format) is mandatory for a corresponding submission in any task to be eligible in the official ranking.
● Track 1
o Task 1: Action Recognition
o Task 2: Action Anticipation
o Task 3: Procedure Recognition
● Track 2
We have prizes for top performing teams in each task and the best paper award. The details are available on our challenge
website.
Important Dates
● Train data release: 11:59 PM EST, Jul. 6th, 2023
● Test data release: 11:59 PM EST, Aug. 15th, 2023
● Participation declaration form deadline: 11:59 PM EST, Aug. 25th, 2023 (Data confidentiality agreement required) - All teams must enter before this date!
● Deadline for results submission: 11:59 PM EST, Sep. 1st, 2023
● Submit your inference code + checkpoint: 11:59 PM EST, Sep. 5th, 2023
● Abstract submission: 11:59 PM EST, Sep. 8th, 2023
● Full Paper submission deadline: 11:59 PM EST, Sep. 15th, 2023
● Winner announcement: 11:59 PM EST, Sep. 22nd, 2023
● Conference date: AM session, Oct. 8th, 2023
Organizing Committee
● Nina Jiang, Purdue University
● Yupeng Zhuo, Purdue University
● Juan Wachs, Purdue University
● Andrew W. Kirkpatrick, University of Calgary
● Jessica McKee, University of Calgary
● Kyle Couperus, The Geneva Foundation
● Christopher Colombo, The Geneva Foundation
● Eleanor Birch, Madigan Army Medical Center
● Chad Gorbatkin, Madigan Army Medical Center
● Oanh Tran, The Geneva Foundation
● Jonah Beck, The Geneva Foundation
● DeAnna DeVane, The Geneva Foundation
Contact If you have any questions about the Trauma THOMPSON Challenge, please email Nina Jiang (jiang841@purdue.edu),
Yupeng Zhuo (zhuoy@purdue.edu), and Oanh Tran (otran@genevausa.org).