BME Summer Seminar Series
Wednesday, July 27th, 2022
9:30-10:30AM EST
Via Zoom Meeting – link below*
Evaluation links:
Seokkyoon Hong:
https://purdue.ca1.qualtrics.com/jfe/form/SV_bPdJifZqThzP6wm
Sang Hoon Um:
https://purdue.ca1.qualtrics.com/jfe/form/SV_agF5usVIO1N5AdE
Porous Foam for Wearable Strain Sensing Applications
Seokkyoon Hong (C. Lee, advisor)
Abstract: Strain gauges, particularly in wearable sensing applications, require a high level of stretchability, softness, sensitivity, linearity, and selectivity while suppressing hysteresis, overshoot, and
response/recovery time. To date, none of current strain gauges meet all these requirements at the same time due to their trade-off relationship. Here, we introduce a porous foam that is highly stretchable and effective in strain sensing under tensile deformation
while being irresponsive to other deformations such as compressing and bending. This unique feature enables superior gauge factor and strain range beyond current stretchable strain gauges without a trade-off in performance metrics. This work involves systematic
investigation to disclose the structure-property-performance relationship of the porous foam and demonstrate its utility in wearable sensing applications such as human motion monitoring, human-robot interaction, and health-monitoring of a large animal.
Retooling the neuronal membrane channel with DNA origami
Sang Hoon Um (B. Han, advisor)
Abstract: DNA nanotechnology offers fascinating self-assembled nanostructures that allow for constructing synthetic ion channels with nanoscale precision and controllable functionalization. In particular,
membranal ion channels at dendritic spines generate electric input signals, making them the primary site for processing information. Mimicking the biological channel consisting of DNA nanostructures has drawn significant attention lately. Synthetic ion channels
can enhance real-time imaging of electrically excitable neuronal cells as the functional versatility of DNA nanostructures enables both direct and indirect recording of electric signals from the neuronal membrane.
Investigating and mapping the whole-cell electrophysiology of neurons require rational strategies on DNA structures to enable the stabilized interaction with the cellular membrane. Herein, we design DNA nanotube
with small circular DNA that keeps structural rigidity. During the process, controlled spatial presentation of cholesterol units creates conditions for practical membrane interfacing with minimal aggregation. The DNA-derived nanopore is functionalized with
two phosphorothioate DNA strands to arrest a single quantum dot (QD) in the center nanopore. The incorporation of the QD extends the scale and range of electrically recordable neurons with increased sensitivity and responsiveness.
We will implement a nanopipette with synthetic DNA nanopores that allows direct voltage recording from neuron cells for a direct voltage recording system. DNA nanotubes will be transferred into the neuronal membrane
via recording nanopipette near dendritic spines, creating a nanopipette coupled ion channel with minimal invasiveness.
Furthermore, we will indirectly quantify voltage by delivering DNA nanopores bearing a single QD into the neuronal membrane's core. QD effectively changes the electrical signal in the neural network to the visualized
signal, which is emission spectral changes of QD.
By applying DNA nanotube as a versatile platform to the various voltage recording system, we aim to explore excitatory postsynaptic potential of neurons and shed light on the complexity of its processes.
*Join Zoom Meeting
https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz09
Meeting ID: 921 6873 9019
Passcode: biomedical
Liz Rowen
She/Her
Graduate Program Assistant
Weldon School of Biomedical Engineering
Martin C. Jischke Hall of Biomedical Engineering
206 S. Martin Jischke Drive
West Lafayette, IN 47907-2032
o: 765-494-1197
