BME MONDAY ROUNDTABLE

APRIL 3, 2023

HAPPY GRAD STUDENT APPRECIATION WEEK!

 

DEPUTY HEAD’S NOTE

 

DEPUTY HEAD’S NOTE

 

 

Important MJIS Alert

 

Starting Monday, May 22nd, Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details.

 

UPCOMING IMPORTANT DATES

 

Week of April 4

 

Mon. Apr. 3 – Fri., Apr. 7:  Grad Student Appreciation Week. Our grad students are superheroes! Let us show you how much we appreciate you! Monday – Not all heroes wear capes! Grab a token of appreciation, 3-4:00 p.m.; Tuesday – Get your POW! back with a snack, 10-11:00 a.m.; Wednesday – A SOUP-er Peer Mentoring Lunch, 11am-1pm; Thursday – Super-charge your morning! 9:30-10:30 a.m.; Friday – Grab a “Frozone” Treat! 3-4:00 p.m. See flyer for details.

 

Mon., April 3: BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation:  Small-scale Technologies for Enhanced Diagnostics and Therapeutics.

 

Mon., April 3: BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor), 4:00 p.m., MJIS 2001 or via Zoom. Title of presentation: Characterization of CSF flow using physics-guided enhancement of 4D flow MRI.

 

Mon., April 3:  Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 p.m. via Zoom. Xiaoli Chen, MD, PhD, Professor and General Mills Chair in Genomics for Healthful Foods, Department of Food Science and Nutrition, University of Minnesota – Twin Cities will present “A Deeper Understanding of Adipocyte-Derived Factors in metabolic Health.” Zoom link: https://iu.zoom.us/s/87501979533

 

Tues., April 4: BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), 1:30 p.m., DLR 131 and via Zoom. Title of presentation: “Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus.”

 

Wed., Apr. 5:  BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Junhong Chen, PhD, Crown Family Professor of Molecular Engineering, University of Chicago and Lead Water Strategist and Senior Scientist, Science Leader for Argonne in Chicago presents “2D Nanomaterials-based Field-effect Transistor for Rapid Chemical and Biological Sensing.”

 

Wed., Apr. 5:  Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.”

 

Wed., April 5: IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor), 10:30 a.m., via Zoom. Title of Thesis Research: Elucidating pathological correlations between Traumatic Brain Injury and Alzheimer’s Disease

 

Wed., April 5: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Dr. Matthias van Osch, Professor, C.J. Gorter MRI Center, Department of Radiology, Leiden University, the Netherlands will present Advances in non-invasive MRI for assessing brain physiology: Hemodynamics and brain clearance. Zoom link: https://bit.ly/3HsTf5R  Seminars are sponsored by Plexon and the Center for Paralysis Research at Purdue.

 

Thurs., Apr. 6: BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging.

 

Thurs., Apr. 6:  Seminars in Hearing Research at Purdue (SHRP), 10:30 a.m., LYLE 1150 and via Zoom. James Bundy, UG Student, Computer Science, will present “A New Model of Auditory Aging in Chinchillas: Chronic Application of Furosemide to the Round Window.”

 

Thurs., Apr. 6:  Special BMS 692/CPB 697 Seminar, 12:30 p.m., LYNN 1136. Dr. Matthew Harris, Associate Professor in the Department of Genetics at Harvard Medical School and at the Department of Orthopedics at Boston Children’s Hospital will present “Inherent Capacity for Change: Latent Developmental Potential and the Evolution of the Skeleton.”

 

Thurs., Apr. 6:  BME Faculty and Staff Town Hall, 1:00-2:00 p.m., MJIS 2001. Arvind Raman, the next dean of Purdue’s College of Engineering starting April 1, will begin hosting town halls for Purdue Engineering’s academic units and listening sessions for faculty and staff in April and May. The main goal for the town halls is to seek input and advice on the College’s priorities for the coming years. Faculty and staff are invited to attend the town hall of their respective academic unit. Registration is not required for the town halls.  A zoom link will be provided for each unit’s town hall; they will not be recorded. Please bring a laptop or smart phone to the town hall as it will be an interactive session.

Zoom link: https://purdue-edu.zoom.us/j/93333532289?pwd=U00wLytBK2dpbERQNVpQRXJ0RndJdz09

 

Fri., Apr. 7:  BME PhD Preliminary Exam Announcement for Peter J. Brumm (T. Kinzer-Ursem, advisor), 10:30 a.m., DLR 131. Research Title: Computational Models determine how 𝑪𝒂^(𝟐+)signal decoding controls subcellular actin organization by quantifying neuronal dendritic spine regulation.

 

Upcoming important deadlines and info.

 

Mon., April 10: BME Master's Defense Announcement for Robert Thurston (J. Rispoli, Chair), 1:00 p.m., MJIS 2001. Title of the Thesis Research: Modeling of Radiofrequency Wave Propagation in the Body.

 

 

Mon., April 10: BME Master's Defense Announcement for Jacob Larsen (E. Nauman, advisor), 11:00 a.m., via Zoom. Title: Characterization of chemical and mechanical properties of porcine brain tissue in vitro

 

Tues., April 11:  BME-IBSC PhD Defense Announcement for Antonia Šušnjar (J. Rispoli and T. Talavage, Co-Chairs), 1:00 p.m., Purdue Graduate Student Center, Room 105 and via Zoom. Title of the Thesis Research: Clinical Applications of Magnetic Resonance Spectroscopy

 

Tues., Apr. 11: Shah Family Global Innovation Lab 2023 I2D Expo, Student Poster Session, Dudley Atrium, 11:30 a.m. - 1:30 p.m., Seed Grant Showcase, WSLR 116, 2:30-4:30 p.m., Keynote and Awards, ME 1130, 5:30-7:00 p.m. Go here to register for all events and for additional information: https://engineering.purdue.edu/GEP/ShahLab/Expo2023/Expo_2023

 

Wed., April 12: BME-IBSC PhD Defense Announcement for Jennifer L. Anderson (C. Goergen, advisor), 12:30 p.m., MJIS 2001 and via Zoom. Title: The Role of Renal Compartment Syndrome in renal injury during pregnancy 

 

Thurs., April 13: BME PhD Defense Announcement for Ángel G. Enríquez Mujica (H. Lee, advisor), 9:00 a.m., MJIS 2001 and via Zoom. Title: Magnetic actuators for applications in biomedical devices and a novel thrombectomy catheter.

 

Wed., April 19: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. Dr. Kinam Park, Showalter Distinguished Professor of Biomedical Engineering at Purdue  will present Drug Delivery Systems: The Revolution-Evolution Cycle. Zoom link: https://bit.ly/3HsTf5R  Seminars are sponsored by Plexon and the Center for Paralysis Research at Purdue.

 

Fri., April 21:  Upcoming Indiana Life Sciences Collaboration Conference:  Digital Health – The “Buzz” and the Reality,” 8:00 a.m. – 5:00 p.m., Taft-Regions Tower, Indianapolis. The FDA defines digital health as “mobile health (mHealth), health information technology (IT), wearable devices, telehealth and telemedicine, and their relationship to personalized medicine”. The pandemic accelerated its adoption across healthcare. This conference will take a look at the progress that has actually been made, further opportunities and issues still needing to be ironed out so digital health can reach its full potential. For more information and to register, go to: https://kelley.iu.edu/faculty-research/centers-institutes/business-of-life-sciences/conference-series/digital-health.html

 

Tues., Apr. 25-Thurs., Apr. 27: Artificial Intelligence in Healthcare Innovation: Moving from Reactive to Proactive Conference hosted by the Regenstrief Institute and Indiana University School of Medicine, Department of Biostatistics & Health Data Science, April 25-27. Registration is free, and available at regenstrief.org/ai-conference-2023

 

Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research.  For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial

 

Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions.

 

Committee Updates

 

Academic Programs Update

 

REMINDER to Fall teaching faculty: The teaching schedule for Fall has been published and for those offering classes, you should be able to view your course within MyPurdue or the online Schedule of Classes.

 

Fall deadlines are already approaching. Therefore, please complete the attached Course Info Form about the need for any textbooks OR supplemental materials, AND the need for any exams (Evening or Final Exams) for your course. Please return the attached form to Cindy Holderbaum as soon as you know that information or no later than Friday, 4/14. 

 

Also send Cindy the syllabus for your course. We will accept drafts at first, but please remember to send the final one whenever it is ready. The basic requirements for a syllabus, as mandated by the provost, can be found here: https://www.purdue.edu/innovativelearning/developing-courses/syllabus-template/  Cindy will upload syllabi into the Registrar’s Course Insights website on your behalf.

 

Undergraduate Programs Update

 

BMES is holding our annual Spring Undergraduate Forum in MJIS 1001 from 6-7:30 pm on Thurs., April 6th. Many of you joined us in November for our Fall Open Forum. This event has historically served as an opportunity for undergraduate students to voice their questions, comments, and concerns via a collective conversation. Before this semester's forum, BMES will be compiling data regarding course-specific feedback, DEI concerns, and feedback regarding the Purdue-IUPUI transition. Here is our preliminary forum survey. Survey Link: https://tinyurl.com/PurdueBMEForum2023

 

The high success we've had with this event in the past has been contingent on high levels of participation from students and faculty alike. We would appreciate your support in advertising this event and the survey to your students. Historically, instructors usually advertise this event with Brightspace announcements and including them in lecture slides. 

 

All feedback, both in the survey and at the forum, will be documented and forwarded to you all! We also would love to have as many faculty to attend this event, as we discuss various courses focusing on the sophomore and junior level classes. If you are able to make time to attend, please stop by, and food will be provided!

 

Questions:  Contact Anisha Rath, Biomedical Engineering Society Vice President, rath2@purdue.edu|

 

Graduate Office Update

 

Good afternoon, graduate students!

 

I hope you enjoyed your Spring Break last week. Did you know there is a multitude of fellowship opportunities for Graduate Engineering students found on our website? This list includes external fellowship programs you can apply for, and each award lists eligibility requirements and a link to find out more information. For instance, here are some awards for you to consider:

For more information on all of the 150+ fellowship opportunities listed, please visit: https://engineering.purdue.edu/Engr/Academics/Graduate/fellowship-list

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below.

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011). Details below.

 

BMEGSA General Body Meetings – All BME graduate students are welcome, and encouraged to attend! Upcoming meetings:

Thursday, April 20th 3:30PM-4:30PM 

All meetings are held in MJIS 2001 in person only.

 

Graduate Admissions Update

 

Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions

DateDATE

Activity

April 15

Graduate applicant acceptance deadline

 

Research Update

 

To safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and “hidden” predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned.

https://www.science.org/content/article/fast-growing-open-access-journals-stripped-coveted-impact-factors

https://retractionwatch.com/2023/03/21/nearly-20-hindawi-journals-delisted-from-leading-index-amid-concerns-of-papermill-activity/

 

Participants needed for a Motor Function Study, “Development of a Diagnostic System for Assessment of Motor Impairment,” IRB# IRB-2022-1299. See below for details.

 

Resources and further information

 

BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), Mon., April 3, 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation:  Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Committee: Luis Solorio, Chair; Craig J. Goergen; David J. Cappelleri; Yoon Yeo

Abstract: Miniaturization of technologies to milli-, micro- and nanoscale offers numerous advantages for diagnostic and therapeutic biomedical applications. In comparison to their macro-scale counterparts, these small-scale systems are more portable, less invasive and less costly. They can facilitate rapid, sensitive and high throughput detection of abnormalities, help track disease progression, reduce sample consumption and improve therapeutic efficacy of drug delivery while decreasing systemic toxicity. Thus, there is clearly a need for creating innovative milli-, micro- and nanoscale tools that can uncover new possibilities in detection and treatment of various types of diseases. The overall objective of this dissertation was to develop novel small-scale technologies that could help enhance diagnostic and/or therapeutic outcomes in patients with cancer, opioid addiction and inflammatory bowel disease. First, we developed an echogenically stable nanodroplet ultrasound contrast agent with potential applications in diagnostic extravascular tumor imaging and targeted cancer therapies. Then, we created a polymer blend microsphere system that could be integrated in prescription opioid tablets to develop an abuse-deterrent formulation against smoking. Finally, we designed a release system for localized delivery of aminosalicylates from magnetically actuated millirobots in the colon to improve therapeutic outcomes in patients suffering from inflammatory bowel disease. Overall, the technologies we developed could serve as a basis for designing diagnostic and therapeutic tools that are superior to currently existing platforms.

Zoom Link: https://purdue-edu.zoom.us/j/92472577791?pwd=YUxuSDVPMlV3cHFBY1lYanJPYmFWdz09
Meeting ID: 924 7257 7791, Passcode: 473469

 

BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor), Mon., April 3, 4:00 p.m., MJIS 2001 or via Zoom. Title of presentation: Characterization of CSF flow using physics-guided enhancement of 4D flow MRI.

Committee: Vitaliy L. Rayz, Chair; Amy J. Schwichtenberg; Edward J. Delp; Michael Markel

Abstract: Cerebrospinal fluid (CSF) plays a diverse role within the skull including cushioning the brain, regulating intracranial pressure, and clearing metabolic wastes via the glymphatic system. Disruptions in CSF flow have long been investigated for hydrocephalus-related diseases. Recently, changes in CSF flow have been implicated in neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. It remains difficult to obtain in vivo measurements of CSF flow which would enable further study of disease initiation, progression, and treatment. Three-directional phase-contrast MR imaging (4D flow MRI) has been used to measure CSF velocities within the cerebral ventricles. However, there remain challenges in balancing acquisition time, spatiotemporal resolution, and velocity-to-noise ratio. This is complicated by the low velocities and long relaxation times associated with CSF flow. To address these challenges, we have applied physics-guided neural networks (PGNN) to super-resolve and denoise synthetic 4D flow MRI of CSF flow within the 3rd and 4th ventricles using novel loss functions. These loss functions are specifically designed to ensure that high-resolution estimations of flow fields are physically consistent and temporarily coherent. We apply these PGNN to various test cases including synthetically generated 4D flow MRI in the cerebral ventricles and vasculature, in vitro 4D flow MRI acquired at two resolutions in 3D printed phantoms of the 3rd and 4th ventricles, and in vivo 4D flow MRI in a healthy subject. Lastly, we propose to use these methods to investigate the influence of vasculature changes to CSF flow in the ventricles and associated implications to conditions such as idiopathic normal pressure hydrocephalus.

Zoom link: https://iu.zoom.us/j/86147472960

 

BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), Tues., April 4, 1:30 p.m., DLR 131 and via Zoom. Title of presentation: “Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus.” Committee: Elsje Pienaar (Major Professor), Tamara Kinzer-Ursem, Nan Kong, Shelby O’Connor, David Umulis

Abstract: Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic infections, such as Human Immunodeficiency Virus (HIV). Animal models of HIV have demonstrated that IL-15 agonists can suppress the virus, but this was transient and was not observed in all cohorts. We developed a mechanistic mathematical model of IL-15 therapy of HIV to explain these differences in efficacy and to explore solutions. First, the model was applied to evaluate mitigating factors, including immune regulation, viral escape, and drug tolerance, using Akaike Information Criterion.  We found that immune regulatory mechanisms could explain the viral rebound observed with continued IL-15 therapy. Next, the model was expanded to allow it to simultaneously explain both the transient viral suppression noted above and the lack of viral suppression observed in another animal cohort.  In this cohort, the model suggested that higher pre-treatment viral load came with higher activation of immune cells and a balancing regulatory inhibition of cytotoxicity. Finally, we conducted stability analysis at a range of IL-15 therapeutic strengths. While there was an ideal IL-15 strength, monotherapy could not maintain viral levels below what would clinically be considered to be safely controlled. Stable viral control in the model required the combination of IL-15 with blockade of key regulatory pathways. Immune therapy of complex diseases will likely require combinations of medicines that boost the immune response at multiple key points. Mathematical models like this can expedite development of these treatments.

Place: Hall for Discovery and Learning Research DLR 131 and on Zoom

https://purdue-edu.zoom.us/j/94454650628?pwd=ZnFUWkJCSXFtSER4VlVPS2xqeVlJQT09

 

BME Distinguished Seminar Series, Wed., Apr. 5,  9:30 a.m., MJIS 1001 and via Zoom. Junhong Chen, PhD, Crown Family Professor of Molecular Engineering, University of Chicago and Lead Water Strategist and Senior Scientist, Science Leader for Argonne in Chicago presents “2D Nanomaterials-based Field-effect Transistor for Rapid Chemical and Biological Sensing.”

Abstract: This talk will present a powerful approach to real-time chemical and biological sensing through molecular engineering of 2D nanomaterials in a field-effect transistor platform. The working principle of the sensor is that the conductivity of 2D nanomaterial channel changes upon binding of chemical or biological species to molecular probes anchored on the nanomaterial surface. As such, the presence and the concentration of analytes (e.g., heavy metals, proteins, bacteria, viruses) can be determined by measuring the sensor resistance or impedance change. The patented technology allows for real-time detection of deadly water contaminants and biological species with high sensitivity and selectivity in field settings for one-time testing or in-line continuous flow testing. The talk will focus on the molecular engineering aspects of the sensor device (e.g., engineering nanomaterial channel, molecular probe, and device passivation) through both theoretical and experimental approaches. The talk will also include a brief introduction on the translation of the platform technology from concept to prototype product through partnership with industries.

Biography: Junhong Chen is currently Crown Family Professor of Pritzker School of Molecular Engineering at the University of Chicago and Lead Water Strategist & Senior Scientist at Argonne National Laboratory. He also serves as the Science Leader for Argonne’s presence in the City of Chicago (Argonne in Chicago). Prior to coming to Chicago, Dr. Chen served as a program director for the Engineering Research Centers program of the US National Science Foundation (NSF) and the director of NSF Industry-University Cooperative Research Center (I/UCRC) on Water Equipment & Policy (WEP). He founded NanoAffix Science LLC to commercialize real-time water sensors based on 2D nanomaterials.  Dr. Chen received his Ph.D. in mechanical engineering from University of Minnesota in 2002 and was a postdoctoral scholar in chemical engineering at California Institute of Technology from 2002 to 2003. His current research focuses on nanomaterial innovation for sustainable energy and environment. Dr. Chen has published over 260 journal papers and has been listed as a highly cited researcher (top 1%) in materials science/cross-field by Clarivate Analytics. He is an elected fellow of National Academy of Inventors and the American Society of Mechanical Engineers (ASME).

~ BME Host: Chi Hwan Lee ~

NOTE: Students registered for the seminar are expected to attend in-person.

Zoom link:  https://purdue-edu.zoom.us/my/chihwanlee

 

Frontiers in Biophysics Seminar Series, Wed., Apr. 5,  1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.” Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering.

 

IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor), Wed., April 5, 10:30 a.m., via Zoom. Title of Thesis Research: Elucidating pathological correlations between Traumatic Brain Injury and Alzheimer’s Disease.

Committee: Major Professor: Dr. Riyi Shi, M.D., Ph.D.;  Dr. Fang Huang, Ph.D.;  Dr. Joesph Rispoli, Ph.D.;  Dr. GuangJun Zhang, M.D., Ph.D.

Abstract: Traumatic Brain Injuries (TBI) are a major cause of disability and death in the United States. One of the greatest consequences of the disease is the resulting long-term damage, especially in milder injuries where the damage is initially subclinical and thus lacking acutely observable manifestations that over time can compound significantly. Among these chronic issues, Alzheimer’s Disease (AD) could be the most serious. While multiple studies demonstrate an increased likelihood of developing neurodegenerative diseases in response to TBI, the underlying mechanisms remain undefined and limited treatment options are currently available. Multiple hypotheses have been postulated based on various animal and clinical models, contributing a great deal to our current knowledge base and implicating several related-targets of interest (i.g. oxidative stress, inflammation, proteostasis-disruptions). While extremely valuable, these in vivo examinations are physiologically and ethically complex: there is currently no model capable of separating and visualizing TBI-induced sub-cellular damage in the moments immediately following injury, and the associated long-term changes. Further, no mechanistic study has been performed to link mechanical-trauma independently with neurodegeneration initiation via protein aggregation. It is clear that additional investigative tools are needed to rectify these intricate issues, and while in vitro methodologies generally offer the type of resolution required, no such model replicates these phenomena. Therefore, we introduce the “TBI-on-a-chip” in vitro concussive model, with a series of concomitant targeted-experiments to address this urgent, currently unmet need. Utilizing TBI-on-a-chip, we directly observe evidence of impact-induced functional and biochemical consequences, while isolating oxidative stress as a key, contributing component.

Zoom link: https://purdue-edu.zoom.us/j/97333625618

 

BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), Thurs., Apr. 6, 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Thesis Committee: Craig J. Goergen, Chair; Steven R. Steinhubl; Gregory J. Loomis

Abstract: Cardiovascular disease has been the leading cause of death in the United States for over 70 years. To evaluate the extent and progression of cardiovascular disease, non-invasive imaging techniques are frequently used clinically and pre-clinically. Current echocardiographic and cine magnetic resonance approaches rely on measurements that are typically obtained from two-dimensional images, which assumes uniformity of the structure being evaluated. To explore methods to potentially address these shortcomings, our group has developed and validated high frequency four-dimensional ultrasound techniques as well as created a software toolbox that allows for measurement of myocardial kinematics. In this thesis, I assisted in the application of these methods to two murine models of disease states: myocardial infarction and aortic aneurysm. Another study I aided in focused on cardiac magnetic resonance imaging data from patients with Duchenne muscular dystrophy. From our software, we are able to obtain various strain and strain rate estimates that reveal significant functional changes in infarction and Duchenne muscular dystrophy earlier than standard measurement techniques. Furthermore, we are able to identify vascular expansion, transmural thickening, and changes in hemodynamics prior to aneurysm development. Earlier detection and localization allows for more targeted surveillance and interventions, which ultimately may result in improved clinical outcomes.  Ideally, these findings can be used to expand the capabilities of cardiac research and the development of clinically applicable imaging techniques and treatments to better address underlying cardiovascular pathophysiology.

Zoom link: https://iu.zoom.us/j/89684973230

 

Seminars in Hearing Research at Purdue (SHRP), Thurs., Apr. 6,  10:30 a.m., LYLE 1150 and via Zoom. James Bundy, UG Student, Computer Science, will present “A New Model of Auditory Aging in Chinchillas: Chronic Application of Furosemide to the Round Window.”

Abstract: In humans, hearing loss can come from many sources, from hair cell damage to degradation of other ear components. In auditory neuroscience, a hotly debated topic is which factor is primarily responsible for age-related hearing loss (ARHL). One of the proposed causes of ARHL is a drain of endocochlear potential, which is the battery that allows hair cells to transmit electrical signals. This battery can also be drained by furosemide, which results in temporary hearing loss. To measure the effects of the drained battery alone, in 2004, David Mills and Richard Schmiedt used an implanted pump in gerbils to apply furosemide to the middle ear over several weeks. Mills and Schmiedt found the chronic application of furosemide in young gerbils produced readings remarkably similar to aging. The present study examines whether this approach is possible in chinchillas: an osmotic pump will be implanted and furosemide will be delivered to the cochlea. Compared to gerbils, the auditory system in chinchillas is closer that of humans, and due to this, chinchillas are a more established hearing loss model. However, chinchillas' 15-year lifespan has limited their use in aging studies. Here, we propose a model of ARHL in chinchillas, which will allow for more powerful studies in the future to analyze the factors contributing to hearing loss and how they interact. This may allow for studies in chinchillas that analyze differences between hearing loss due to noise exposure and hearing loss due to aging, which can lead to more individualized treatments for hearing loss.

Zoom link for remote attendees: https://purdue-edu.zoom.us/j/4326340458 Meeting ID: 432 634 0458

The working schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule

The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts

 

BME PhD Preliminary Exam Announcement for Peter J. Brumm, Fri., Apr. 7, 10:30 a.m., DLR 131. Research Title: Computational Models determine how 𝑪𝒂^(𝟐+)signal decoding controls subcellular actin organization by quantifying neuronal dendritic spine regulation.

Thesis Committee Members: Tamara Kinzer-Ursem (chair),  Taeyoon Kim (member),  Elsje Pienaar (member),  Jeremiah Zartman (member)

Abstract: Dynamic changes in the connection strength between neurons provide a cellular basis of neural function. Following Ca2+ stimulation, neurons have been shown to change in both electrophysiological and structural properties. Critical to both changes are interactions between dodecameric Ca2+/Calmodulin-dependent Kinase II (CaMKII) and the Actin Cytoskeleton. While both CaMKII and the Actin Cytoskeleton have been implicated in synaptic plasticity and multiple neurological diseases, the explicit molecular mechanisms have not been quantified. Using reaction-diffusion models, this study quantifies the relative contribution of various hypothesized mechanisms responsible for the regulation of the Actin Cytoskeleton by CaMKII, and vice versa. Explicit quantification of molecular mechanisms provides a basis for neurological diagnostics as well as pharmaceutical interventions.

 

BME Master's Defense Announcement for Robert Thurston, Mon., April 10, 1:00 p.m., MJIS 2001. Title of the Thesis Research: Modeling of Radiofrequency Wave Propagation in the Body. Everyone is invited to attend the public presentation.

Thesis Committee: Dr. Joseph Rispoli (BME), Chair; Dr. Elsje Pienaar (BME); Dr. Luis Gomez (ECE)

Abstract: Understanding how radiofrequency (RF) pulses propagate through and interact with the body is crucial for determining regions of the body that are subject to potential heating or damage. Applications of pulse propagation include magnetic resonance imaging (MRI) and cell phones which utilize directed pulses that can cause undesirable heating in the body. Notably, these interactions are closely when monitored in organs, but due to composition and location of organs, there exist multiple transition zones between tissues with differing physical and electrical properties. Therefore, structures such as the skull or pelvis may limit entry of the pulse while creating internal refractions once the signal enters the body. This study utilizes finite-difference time-domain (FDTD) solvers to simulate the potential interactions of an external, targeted pulses or waves in the body, specifically the prostate and the brain. This study is divided into two sections with the first section studying the interactions of electromagnetic fields that are generated from 5G cell phones and a human prostate. These interactions will be evaluating regions in the prostate more susceptible to local peaks in specific absorption rates (SAR) and damage to the tissue. The second section will focus on the effects of targeted pulses on the brain. By observing the local peaks in electric field, the general propagation patterns of the wave once it enters the head, and checking for internal reflections of the wave, this study observes which regions of the brain might be susceptible to abnormal events such as neuron triggers or hormone changes.

 

BME Master's Defense Announcement for Jacob Larsen, Mon., April 10, 11:00 a.m., via Zoom. Title: Characterization of chemical and mechanical properties of porcine brain tissue in vitro

Committee: Dr. Eric A. Nauman, Chair, Dr. Vitaliy L. Rayz, Dr. Yunjie Tong

Abstract: Traumatic brain injury (TBI) is characterized by a violent or sudden blow to the head that causes tearing or bruising of the brain tissue and its supporting blood vessels. Determination of the mechanical properties of gray and white matter is critical for the creation of computational models of healthy and TBI-damaged brain tissues. Current in vivo methods to characterize brain tissue, such as 3D amplified MRI (aMRI) and magnetic resonance elastography (MRE), are highly vulnerable to motion artifacts and have limited techniques to exert mechanical loads on the brain. Therefore, in vitro testing was employed to estimate the chemical composition of gray and white matter using Fourier Transform Infrared (FTIR) spectroscopy and the stress responses of the brain tissues to high compressive deformations via unconfined compression. Attenuated total reflectance (ATR) was run in conjunction with FTIR spectroscopy to eliminate the need for sample preparation. Unconfined compression of gray and white matter samples was performed to 70% of the total sample height at a constant strain rate of 0.5 Hz. Results showed significant increases in the absorbances of white matter (p < 0.05) in the characteristic lipid and carbohydrate regions of the FTIR spectra when compared to gray matter. Within the initial 10% toe-region of the stress-strain curve, white matter is observed to absorb significantly greater compressive loads (p < 0.05) than gray matter. These results indicate an incomplete characterization of brain tissue; therefore, additional in vitro and in vivo methods are still necessary in combination to accurately characterize brain tissue mechanics in TBI and non-TBI patients.

Zoom link: (https://purdue-edu.zoom.us/j/94322528882?pwd=cGRxZlMzUXo4ZHpRUm9oc1JlQmxkUT09)

 

BME-IBSC PhD Defense Announcement for Antonia Šušnjar (J. Rispoli and T. Talavage, Co-Chairs), Tues., April 11, 1:00 p.m., Purdue Graduate Student Center, Room 105 and via Zoom. Title of the Thesis Research: Clinical Applications of Magnetic Resonance Spectroscopy

Thesis Committee members: Dr. Joseph Rispoli, Major Professor, Co-Chair; Dr. Thomas Talavage, Co-Chair; Dr. Ulrike Dydak; Dr. Uzay Emir

Abstract: Magnetic resonance spectroscopy (MRS) is a non-invasive imaging technique that provides unique information about the biochemical composition of the human body. By excluding the overwhelming signals from water and fat, clinically relevant biomarkers such as lactate, N-acetyl aspartate, choline, creatine, glutamate/glutamine (Glx), gamma-aminobutyric acid (GABA), glutathione, and myoinositol can be reliably quantified. MRS has diverse applications in investigating the metabolic window of a wide range of biochemical processes.

      Here, we have utilized MRS to better understand chemical changes associated with neurological disorders and treatment response. We have investigated neurometabolic imbalances in brain regions related to post-traumatic stress disorder (PTSD) symptoms and found that neurometabolic changes are brain region-specific in PTSD population compared to healthy controls. MRS was applied to better understand the neurobiological processes of hyperbaric oxygen therapy in military veterans with clinically diagnosed traumatic brain injury and/or PTSD. From preliminary data, we found the largest neurometabolic changes in the insula – a core component of body awareness. Lastly, MRS was utilized to understand neurochemical changes during and following transcranial Direct Current Stimulation (tDCS) for modulation of brain activity in a large healthy cohort. Increases in primary inhibitory neurotransmitter GABA, energy marker creatine, and excitatory neurotransmitter Glx were observed.

     With improved specificity and the ability to probe microstructural and chemical changes, MRS represents a powerful tool for investigating various disorders and treatment responses.

Zoom link:  https://purdue-edu.zoom.us/j/98032847567

 

BME-IBSC PhD Defense Announcement for Jennifer L. Anderson, Wed., April 12, 12:30 p.m., MJIS 2001 and via Zoom. Title: The Role of Renal Compartment Syndrome in renal injury during pregnancy 

Thesis Committee Members: Dr. Craig J. Goergen, Chair; Dr. David G. Reuter; Dr. Abigail Cox; Dr. Bruno Roseguini; Dr. George R. Wodicka 

Abstract: Preeclampsia and other hypertensive disorders of pregnancy impact 2-8% of pregnancies with often devastating results. Current treatment methods resort to birth, which forces the fetus into the world before they are fully developed but can save the mother’s life. Preeclampsia is broadly considered to be of placental origin and current etiologic understanding focuses on systemic endothelial dysfunction triggered by an imbalance of vasoregulatory factors released by this maternal/fetal organ. This imbalance explains many early-term cases but fails to adequately address later cases where this imbalance is not always seen. Conversely, ischemia-reperfusion of the kidney is known to correlate with endothelial dysfunction, and preeclamptic women are known to have a stenosis in their left renal vein (LRV) in the supine position (on their back). Herein, we suggest that extrinsic compression of the LRV by the gravid uterus, without collaterals, produces a renal injury which can induce systemic endothelial cell dysfunction. We theorize this compression is position dependent and produces renal ischemia through an unchecked cycle of increased intrarenal pressure, subsequent afferent arteriole constriction and decreased glomerular perfusion, and activation of the renin-angiotensin-aldosterone system. We aim to elucidate this through murine studies of a surgically induced LRV stenosis and a retrospective clinical study where the maternal renal veins are measured from magnetic resonance images. Findings from this work suggest partial renal venous outflow obstruction leads to renal injury but could be moderated through alternative maternal resting positions. This potential alternative pathologic mechanism has significant clinical implications for future therapies targeting this condition. 

Zoom link: https://purdue-edu.zoom.us/j/97092123267?pwd=OWdUeXhZUklUeHRPYTFyQ1FaV2hqUT09

 

BME PhD Defense Announcement for Ángel G. Enríquez Mujica, Thurs., April 13, (H. Lee, advisor), 9:00 a.m., MJIS 2001 and via Zoom. Title: Magnetic actuators for applications in biomedical devices and a novel thrombectomy catheter. Everyone is invited to attend the public presentation.

Thesis Committee: Hyowon (Hugh) Lee (Major professor), Luis Solorio, Chi-Hwan Lee, Daniel Sahlein

Abstract: The untethered transfer of energy and the scalability of magnetic actuators can add novel functionalities to an otherwise passive system. For example, wireless magnetic actuation can turn static 2D and 3D cell cultures into a more physiologically-relevant dynamic environment that can limit contamination. Moreover, magnetic microactuators can turn conventionally static indwelling catheters and implantable sensors with limited functional lifespan into more active and reliable medical devices. In this work, I will demonstrate examples of novel biomedical microdevices enabled by magnetic actuation. First, I will describe a soft polymer magnetic actuator that can facilitate the study of a physiologically relevant cell culturing system. By cyclically stretching an extracellular matrix protein in a 3D cell culture, this system can elucidate the process by which breast cancer cells respond to a dynamic environment in the lungs. Our results demonstrate a clear suppression of cancer cell progression due to cyclic stretching that has implications for a mechanical role in the dormancy and reactivation of metastasizing breast cancer cells. As a second application, I will demonstrate the use of magnetic microactuators to regenerate biosensors to prolong their functionality. Our preliminary results suggest that the motion of the actuator on the sensor surface can maintain biosensor signal integrity and prevents the downstream effects of the foreign body response. Finally, I will present the design and proof of concept testing of a novel aspiration thrombectomy catheter meant to improve the engagement between the catheter and the blood clot being removed. Our preliminary results demonstrate the added benefit of incorporating a microstructure in an aspiration catheter lumen with increased embolism retraction force. 

Zoom link: https://purdue-edu.zoom.us/j/98595923252 ; Meeting ID: 985 9592 3252

 

Participants Needed for Research Study:

(Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.)

I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task.  This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements.  The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299.

If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha@purdue.edu.  

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011).

Fall 2023, 3.0 credit hours

Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only)

Prerequisite: BME Graduate Standing

Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout.

Weekly Course Topics:

August 23            Pediatrics Introduction

August 30            Neonatology Introduction

September 6      Pediatric Device Design and Development I

September 13    Pediatric Device Design and Development II

September 20    Pediatric Device Regulation

September 27    Pediatric Clinical Studies

October 4            Pediatric Cardiology

October 18          Pediatric Cardiovascular Surgery

October 25          Pediatric Nephrology

November 1       Pediatric Pulmonology

November 8       Pediatric Wound Healing

November 15     Pediatric Gastroenterology

November 29     Ethical Considerations in Pediatrics

December 6        Future Directions and Trends

Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu

Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate.

 

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001)

 

Week

 

Date

Speaker

Host

 

Week 12

4/5/2023

Dr. Junhong Chen

Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory

Dr. Chi Hwan Lee

Week 13

4/12/2023

Dr. Chien-Chi Lin

Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI

Dr. Young Kim

Week 14

4/19/2023

Dr. Rachel Surowiec

Assistant Professor of BME at IUPUI

Dr. Young Kim

Week 15

4/26/2023

Dr. James Moon

J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan

Dr. Chi Hwan Lee

The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts

 

Attachments

Course Info Form 2023