BME MONDAY ROUNDTABLE

FEBRUARY 6, 2023

 

DEPUTY HEAD’S NOTE

 

Dear all, I hope you had a good weekend.

 

 

UPCOMING IMPORTANT DATES

 

Week of February 6

Mon., Feb. 6: Celebrating our Associate Professors, 11:30 a.m., Purdue Graduate Student Center (PGSC) 105 A&B. BME’s own Joseph Rispoli will present a 10-minute presentation, followed by an opportunity for discussion. Register at https://purdue.ca1.qualtrics.com/jfe/form/SV_8HX3JSdsyIvf6rs

Mon., Feb. 6: BME PhD defense announcement for Sean M. Rothenberger (V. Rayz, advisor), 3:00 p.m., MJIS 2001 and via Zoom. Title of presentation: Statistical Models of 4D flow MRI Velocity Error using Principles of Fluid Dynamics and Imaging Physics

Wed., Feb. 8: Prospective BME Faculty Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University will present “Traditional and computational development of fluorescence imaging tools for neuroscience.” (Note:  Students registered for credit for the seminar are expected to attend in-person.)

Wed., Feb. 8: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. Dr. Chongli Yuan, Charles Davidson Associate Professor of Chemical Engineering at Purdue will present “Towards understanding persistent molecular markers after traumatic injuries.”

Wed., Feb. 8:  Diabetes Research Virtual Seminar, 2:00 p.m., via Zoom. Barbara E. Corkey, Professor Emeritus of Medicine and Biochemistry, Boston University School of Medicine will present “The ReDox Network: Master Regulator of Metabolism.” Zoom link:  https://zoom.us.j/91323894836 .

 

Upcoming important deadlines and info.

Tues., Feb. 14: Special BME Virtual Seminar, 9:30 a.m. via Zoom. Fiona Kolbinger, Surgical Clinician Scientist at the University Hospital, the National Center for Tumor Diseases and the Else Kroener Fresenius Center for Digital Health in Dresden, Germany, will present “From Anatomy Segmentation to Complication Prediction: The Power of AI in Surgery.” Zoom link:  https://purdue-edu.zoom.us/j/92881451071?pwd=aUQvM1QyWUFPTWdIUEpvQUtBT1Jadz09

Thurs., Feb. 16: BRAG Session, 3:30 p.m., MJIS 2001. Andrew Brightman, Professor of Engineering Practice in Biomedical Engineering, will hold a session titled “Responsive Mentoring for Responsible Research”. Together we will discuss the elements of responsive mentoring of students to guide them on a path of responsible conduct of research. This session is for those who are new to research mentoring or imagine they will be mentors in the near future.  The 60-90 min session will cover information from the Online Ethics Center materials linked here:  ‘Instructor’s Guide to Prepare Research Group Leaders as RCR Mentors’ and the recent research paper here: ‘Ethical Practices and Tips for Improving Engineering Faculty-Student Research Relationships’ in case participants want to look ahead to the content. “Fika”, i.e. coffee/tea + cookies/snacks provided.

Fri., Feb. 17:  Clinical and Translational Sciences (CTSI) Winter Retreat, 9:30 a.m. – 3:00 p.m., Purdue University West Lafayette campus, Hall for Discovery Learning and Research, Room 131. Agenda includes:

·      Introduction from Indiana CTSI

·      Keynote Speakers on women's health research

·      Discussion panels including topics on:

o    Maternal and child health

o    Obesity and chronic diseases

o    Neurodegenerative disorder and aging

o    Women's health in rural areas

Full agenda and registration links at https://engineering.purdue.edu/BME/CTSI/Winter-Retreat . This event is sponsored by the Purdue University Women’s Global Health Institute and the Indiana CTSI. Registration closes February 14.

Fri., Feb. 17:  College of Agriculture Distinguished Professor Renewal Seminar, 1:00 p.m., Deans Auditorium, Pfendler Hall. University policy requires that Named and Distinguished Professors be reviewed every five years. This seminar marks the renewal of Michael Ladisch’s distinguished professorship. The seminar is entitled “Renewable Resources Engineering: Proteins and People at Interfaces.”

Thurs., Feb. 23:  RCHE Graduate Student Seminar Series, 3:00-4:00 p.m., via Microsoft Teams. Presenters include Geonsik Yu (PhD student in Industrial Engineering) and Alexis Hoerter (PhD student in Biomedical Engineering).

Mon., Feb. 27: Center for Diabetes and Metabolic Diseases Pilot & Feasibility Grants, Letter of Intent due to Jeffrey Elmendorf (jelmendo@iupui.edu) by 5:00 p.m.

Wed., Apr. 5:  Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.”

 

PURDUE ADVERSE WINTER WEATHER POLICY

If adverse weather conditions necessitate that a wind chill, snow or ice emergency be declared for the West Lafayette campus, special procedures pertaining to classes, operations, parking, pay and/or attendance will become effective. Jay Wasson, vice president for physical facilities and chief public safety officer, describes procedures for adverse winter weather in this memo.

 

Committee Updates

 

Graduate Office Update

 

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below.

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011). Details below.

 

Awards season is upon us and we will be asking for several nominations with varying deadlines over the next month.  Below is a quick snapshot of all those awards and deadlines.  More detailed emails for each award will be sent separately that will list the criteria and materials needed for the nomination. Two of them look similar (Dissertation and Outstanding Graduate Researcher) so we wanted to make sure that you knew they were actually two separate awards.

Let me know if you have any questions (tsiemers@purdue.edu).

 

Graduate Admissions Update

 

Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions

DateDATE

Activity

Feb 8

Last chance for Research Areas / Faculty to remove students from fellowship consideration

Feb 10

Fellowship offers announced and complete rankings list made available to BME faculty; BME Graduate Office will notify students by email (offer letters distributed as soon as signed by BME Head and COE Dean)

Mar 10

DUE: All Master’s students to be decisioned as either admit, deny or hold

Mar 31

Due: All PhD students to be decisioned as either admit, deny or hold

April 15

Graduate applicant acceptance deadline

 

 

Undergraduate Committee Update

 

CURE – Purdue accepting applications to design course-based undergraduate research - Purdue University News 

 

Purdue professional development program within the Office of Undergraduate Research is now accepting applications from instructors of any discipline for the 2023-24 academic year. CURE – Purdue seeks to develop course-based undergraduate research experiences (CUREs) across the Purdue West Lafayette campus as a way to increase undergraduate students’ overall access to novel research. The program provides instructors with the time and framework for designing a CURE, either by transforming an existing course or developing a new one. CUREs have a number of features and positive outcomes, including increasing the overall capacity for undergraduate research by operating at a larger scale than the traditional apprenticeship model and increasing inclusion by allowing any eligible student to enroll. Research findings suggest additional benefits to instructors:

 

BME Faculty Search Update

 

The Faculty Search Committee has invited four faculty candidates to campus for interviews. If you are interested in meeting with any of the candidates, please contact Jo Gelfand (jo@purdue.edu). All candidates will give a research seminar in MJIS 1001 at 9:30 a.m. on the Wednesday of their visit.

Jan. 18-19 – Jacob Rosenstein, Associate Professor of Engineering, Brown University

Jan. 25-26 – Sunghee Estelle Park, PhD Candidate and CEMB Fellow, Bioengineering, Univ. of PA

Feb. 1-2 – Wei Ouyang, Postdoctoral Fellow, Bioelectronics, Northwestern Univ.

Feb. 8-9 – Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke Univ.

 

 

Resources and further information

 

The Great Lakes NSF I-Corps Hub and Purdue I-Corps are offering various workshops in Spring 2023 that can significantly increase the chances of securing federal proof of concept & commercialization grants like SBIR/STTR, PFI-TT that range from $500k to $1.6 million. The historical success rate for Purdue Faculty, who complete the NSF I-corps workshops, and apply for these competitive NSF research commercialization grants is over 90%. Please find details of the workshops below. 

STEM Jumpstart: Feb 3 – March 24 

Medical Jumpstart: Feb 3 – March 24 

Purdue I-Corps Discovery, Discovery+: Feb 17-March 24; March 31-April 7 

Gain new insights about your research, explore the commercial potential, learn about NSF funding opportunities, and increase your industry and professional network. Learn from our NSF-certified instructors, experienced entrepreneurs, and mentors. 

If a student/Post-doc in your lab is interested in this opportunity and would like to learn more, please reach out to Geetali Pradhan at gpradhan@purdue.edu

 

 

Purdue I-Corps 

Great Lakes hub I-Corps (Jumpstart) 

 

Discovery 

Discovery+ 

STEM specific 

Medical specific 

Duration 

4 workshops 

2 workshops 

5 workshops 

5 workshops 

Schedule 

Feb 17 – March 24, online 

March 31, April 7, online 

Feb 3 – March 24, online 

Feb 3 – March 24, online 

Team requirement

2-4

2-4

2-4

Affiliation 

Purdue Univ, any Midwest Univ 

Purdue Univ, any Midwest Univ 

Hub-affiliated institutions and other Midwest teams 

Hub-affiliated institutions and other Midwest teams 

Prerequisite 

None 

Discovery 

None 

None 

Instructors 

2-3 

2-3 

3-6 

3-6 

Learnings 

Customer Discovery, Product-Market Fit, and Market Assessment 

Market size, Commercialization pathway, Commercialization grants 

Customer Discovery, Product-Market Fit, Market Assessment, Commercialization Pathway 

Customer Discovery, Product-Market Fit, Market Assessment, Commercialization Pathway 

Learn more 

Purdue I-Corps 

STEM Jumpstart 

Medical Jumpstart 

 

 

BME PhD defense announcement for Sean M. Rothenberger, Mon., Feb. 6, 3:00 p.m., MJIS 2001 and via Zoom. Title of presentation: Statistical Models of 4D flow MRI Velocity Error using Principles of Fluid Dynamics and Imaging Physics. Everyone is invited to attend the public presentation.

Advisory Committee: Vitaliy L. Rayz, Chair; Pavlos P. Vlachos; Craig J. Goergen; Michael Markl

Abstract: 4D flow magnetic resonance imaging (MRI) has emerged as an imaging modality capable of assessing cardiovascular flow non-invasively. Despite interest in using these in vivo measurements for cardiovascular disease diagnostics and progression assessment, there are no adequate models of 4D flow MRI’s measurement error. Error models are essential in evaluating accurate hemodynamic biomarkers and judging the quality of 4D flow MRI scans. Here, we present a comprehensive error model of 4D flow MRI velocity measurements using fluid dynamics and imaging physics principles. 4D flow MRI velocity error is described as a multivariate normal distribution which is a function of space and time. The error distribution’s scale is assessed using the principle of conservation of mass, and error correlations are assessed using the novel standardized difference of means (SDM) velocity metric. We define the SDM velocity as the difference between the local mean velocity and the global background mean velocity relative to the standard error of the local mean velocity. We also demonstrate the SDM velocity’s utility in segmenting vessels in 4D flow MRI measurements. This work also introduces a bias error model, which accounts for insufficient spatial resolution and partial volume effects. These bias error estimates serve as one means of validating our proposed 4D flow MRI error model. All algorithms presented are validated in 4D flow MRI measurements in scaled in vitro cerebral aneurysms and in vivo 4D flow measurements. This work ultimately supports the development of reliable biomarkers indicative of cardiovascular disease progression.

Zoom link: https://purdue-edu.zoom.us/j/99467282487

 

Prospective BME Faculty Seminar, Wed., Feb. 8, 9:30 a.m. in MJIS 1001 and via Zoom. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University will present “Traditional and computational development of fluorescence imaging tools for neuroscience”

Abstract: Modern basic research in neuroscience aims to dissect neural activity from genetically identifiable neuron populations within dense neural circuits. Such research has relied increasingly on tools that perform optical imaging and optical stimulation. In this area, my lab develops a diverse toolbox that employs multiple engineering disciplines simultaneously. In this talk, I will highlight our recent gains in protein engineering, optical microscopy, and data analysis. The protein tools will attempt to enable multi-channel optical experiments by increasing spectral separation between fluorescent protein sensors and actuators. The microscopy tools will attempt to support fast volumetric imaging experiments that accurately capture neural activity. The data analysis tools will attempt to find neurons and calculate their neural activity from the large datasets resulting from optical imaging experiments quickly and accurately. Lastly, this talk will touch on the future of the protein engineering pipeline seen through the lens of protein tools in neuroscience.

Bio: Yiyang Gong obtained his B.S. in Electrical Engineering from the California Institute of Technology. He then obtained his M.S. and Ph.D. in Electrical Engineering from Stanford University, training with Prof. Jelena Vuckovic on plasmonic and photonic crystal optical devices. He trained with Prof. Mark Schnitzer at Stanford University as a postdoc in Biology, developing genetically encoded voltage sensors that are advancing the current generation of neuroscience experiments. His current work focuses on imaging neural activity with a combination of engineered protein sensors, optical microscopes, and computational algorithms. His work has been supported by the Beckman Young Investigator Award, the BRAIN initiative, NIH New Innovator Award, NSF CAREER Award, Sloan Fellowship, and Vallee Young Investigator Award.

~BME Host: Hugh Lee~

Zoom link: https://purdue-edu.zoom.us/j/97275864534?pwd=UFNhaDBadVVxRjVxdE5UOTRlT0trUT09&from=addon

 

Seminar for Neurotrauma and Diseases, Wed., Feb. 8, 4:00 p.m., DLR 131 and via Zoom. Dr. Chongli Yuan, Charles Davidson Associate Professor of Chemical Engineering at Purdue will present “Towards understanding persistent molecular markers after traumatic injuries.” The Seminar for Neurotrauma and Diseases, organized by the Center for Paralysis Research, is sponsored by Plexon, a leading neuroscience technology company, and jointly supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Join CPR and our set of amazing speakers as we explore various facets of neurotrauma and diseases and build a community to make long-lasting impacts on neurotrauma research! Seminars will be held on alternating Wednesdays from 4:00-5:00 p.m. in DLR 131, with a hybrid option on Zoom for those who cannot attend in-person at https://bit.ly/3HsTf5R .

 

Special BME Virtual Seminar, Tues., Feb. 14, 9:30 a.m. via Zoom. Fiona Kolbinger, Surgical Clinician Scientist at the University Hospital, the National Center for Tumor Diseases and the Else Kroener Fresenius Center for Digital Health in Dresden, Germany, will present “From Anatomy Segmentation to Complication Prediction: The Power of AI in Surgery.” Zoom link:  https://purdue-edu.zoom.us/j/92881451071?pwd=aUQvM1QyWUFPTWdIUEpvQUtBT1Jadz09

Abstract Surgical tumor resection represents the central component of curative treatment approaches in most patients with cancers of the gastrointestinal tract. While technological innovations such as the adoption of minimally-invasive surgery and the introduction of surgical robots have transformed surgery since the 1970s, postoperative complications remain the third largest contributor to death worldwide. In this presentation, I will demonstrate how Artificial Intelligence-based image recognition and data analysis methods can contribute to the reduction of such complications. Combining routinely available clinical parameters with imaging data and video recordings of minimally-invasive pancreatic and colorectal surgeries, machine learning-based pre- and intraoperative complication risk stratification models were developed. These models could facilitate tailored surgical approaches considering individual cancer patients’ complication risk profiles.

Biography Since 2019, Fiona Kolbinger is a surgical clinician scientist at the University Hospital, the National Center for Tumor Diseases and the Else Kroener Fresenius Center for Digital Health in Dresden, Germany. Her research focus is the intersection of medicine and computer science, as well as the translation of technological innovations, in particular Artificial Intelligence, into clinical practice. Based on automated analysis of medical imaging such as radiological, endoscopic, or microscopic images, she aims to contribute to improving clinical outcomes through more individualized interdisciplinary treatments and better risk and outcome stratification in patients with cancer. Fiona graduated from the University of Heidelberg medical school in 2019 and subsequently completed a research doctorate at the German Cancer Research Center Heidelberg, Germany.

Dr. Kolbinger is a prospective research faculty member and will be hosted by Professor Young Kim.

 

RCHE Graduate Student Seminar Series, Thurs., Feb. 23:  3:00-4:00 p.m., via Microsoft Teams. Presenters include Geonsik Yu (PhD student in Industrial Engineering) and Alexis Hoerter (PhD student in Biomedical Engineering). Geonsik is advised by Yuehwern Yih in Industrial Engineering and will present on: Opinion-Disease Integrated Simulation Model: Examination of Social Features’ Impact on Disease Spread. Alexis is advised by Elsje Pienaar in Biomedical Engineering and will present on: In silico modeling of M. tuberculosis granuloma dynamics. Please mark your calendars and plan to attend at the link below. The Regenstrief Center for Healthcare Engineering brings together researchers and practitioners from multiple disciplines to pursue a proactive, patient-centered, and wellness-focused healthcare delivery system by conducting impactful research that leverages collaborative partnerships.

RCHE’s monthly Graduate Student Seminar is designed to showcase our interdisciplinary faculty and their graduate students.  With this series, we strive to foster a community of students and faculty that can share their knowledge, develop presentations skills, and engage in opportunities to collaborate all with the intention of working together to improve healthcare. 

Microsoft Teams meeting

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Meeting ID: 291 434 447 980
Passcode: wC4C9L

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Frontiers in Biophysics Seminar Series, Wed., Apr. 5,  1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present “Mechanical Stability of Microtubules.” Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering.

 

New Course for Fall 2023:  BME 69500 Pediatric Medical Devices (CRN 14011).

Fall 2023, 3.0 credit hours

Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only)

Prerequisite: BME Graduate Standing

Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout.

Weekly Course Topics:

August 23            Pediatrics Introduction

August 30            Neonatology Introduction

September 6      Pediatric Device Design and Development I

September 13    Pediatric Device Design and Development II

September 20    Pediatric Device Regulation

September 27    Pediatric Clinical Studies

October 4            Pediatric Cardiology

October 18          Pediatric Cardiovascular Surgery

October 25          Pediatric Nephrology

November 1       Pediatric Pulmonology

November 8       Pediatric Wound Healing

November 15     Pediatric Gastroenterology

November 29     Ethical Considerations in Pediatrics

December 6        Future Directions and Trends

Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu

Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate.

 

Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001)

 

Week

 

Date

Speaker

Host

 

Week 5

2/8/2023

Faculty candidate

Dr. Yiyang Gong, Assistant Professor of Biomedical Engineering, Duke University

Dr. Hugh Lee

 

Week 6

2/15/2023

Dr. Ken Yoshida

Professor of BME at IUPUI

Dr. Young Kim

Week 7

2/22/2023

Dr. Rita Patel

Associate Professor, Speech & Hearing Sciences + Associate Professor of Otolaryngology-Head & Neck Surgery at IUSM

Dr. Young Kim

Week 8

3/1/2023

Dr. Joey Wallace

Chair and Professor of BME at IUPUI

Dr. Young Kim

Week 9

3/8/2023

Dr. Hubert Lim

Professor, Department of Biomedical Engineering, Otolaryngology, Institute for Translational Neuroscience Scholar, University of Minnesota

Dr. Hugh Lee

Week 10

3/22/2023

Dr. Daniel DiLorenzo, Assistant Professor, Neurosurgery and Biomedical Sciences, Loma Linda University; Attending Neurosurgeon, Loma Linda VA Medical Center; President Barinetics Corporation

Dr. Matthew Ward

Week 11

3/29/2023

Dr. Nimmi Ramanujam

Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University

Dr. Jackie Linnes

Week 12

4/5/2023

Dr. Junhong Chen

Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory

Dr. Chi Hwan Lee

Week 13

4/12/2023

Dr. Chien-Chi Lin

Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI

Dr. Young Kim

Week 14

4/19/2023

Dr. Rachel Surowiec

Assistant Professor of BME at IUPUI

Dr. Young Kim

Week 15

4/26/2023

Dr. James Moon

J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan

Dr. Chi Hwan Lee

The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts

 

Attachments

2023 CTSI Winter Retreat Flyer v2.pdf

CDMD RFA 2023.pdf

CDMD Application 2023.docx