BME MONDAY ROUNDTABLE

OCTOBER 24, 2022

Happy Diwali to those who celebrate!

HEADS NOTE

Hello Weldon School of Biomedical Engineering,

Congratulations go out to Sandy May, BME’s Graduate Program Administrative Assistant. Sandy recently received the 2022 Community Spirit Award from the Management and Professional Staff Advisory Committee (MaPSAC) and the Campus Support Staff Advisory Committee (CSSAC). For as long as she can remember, Sandra has been actively involved in her community. May’s volunteer experience is wide-ranging and has included roles as a big sister in Big Brothers Big Sisters of America, a youth group leader and a lifetime member of the Beta Chapter of Kappa Kappa Sigma Sorority. She attributes her lifelong passion for service to the role models she had as a child. You can read the full article here: https://www.purdue.edu/newsroom/purduetoday/releases/2022/Q4/biomedical-engineerings-sandra-may-receives-2022-community-spirit-award.html If you get a chance, stop by the academic programs office and give her a hearty congrats on this well-deserved award!

QUICK LINKS

Flu shots

UPCOMING IMPORTANT DATES

Week of October 24

Mon., Oct. 24: Purdue Engineering Distinguished Lecture Series: 12:30-1:30 p.m., ARMS, Kurz Atrium. Nancy Leveson, Jerome C. Hunsaker Professor in Aeronautics and Astronautics, MIT will present “A Paradigm Change for System Safety Engineering (and Security).” Following the presentation will be a panel: “Conflict and complementation between agile methods and systems analysis in developing and maintaining software-intensive systems” from 1:45-2:45 p.m. Both are sponsored by the College of Engineering and the Elmore Family School of Electrical & Computer Engineering. Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_aY0q0Nf8GiPKvjw?utm_source=delivra&utm_medium=email&utm_campaign=PEDLS%20-%20Nancy%20Leveson%20-%20Aug%202022-copy&utm_id=43884000

Mon., Oct. 24: IU Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon, via Zoom. Nourah Almutlaq, MBBS, Pediatric Endocrinology & Diabetology Fellow, Riley Children's Hospital, IUSOM will present “Safety and Efficacy of PTH 1-34 and 1-84 Therapy in Chronic Hypoparathyroidism: A Meta-Analysis of Prospective Trials” and Ala Ustyol, MD, Pediatric Endocrinology Fellow, IUSOM will present "Tracking and Cumulative Lifetime Exposure to IGF-I in 6,459 Healthy Individuals and in SGA Children Treated with GH ".

Zoom link: https://iu.zoom.us/j/83951671092?pwd=WC9GNTJaVTRVcEIyako4cHMvN2FXZz09

(password: 629133)

The Research Seminar Series is hosted by the Indiana University Center for Diabetes and Metabolic Diseases.

Tues., Oct. 25: Purdue Center for Cancer Research Monthly Series on Career Development: A Panel Discussion with Assistant Professors in Cancer Research: Graduate School, Postdoc and Beyond, 12:00-1:00 p.m. via Zoom. Register at: https://purdue-edu.zoom.us/meeting/register/tJYode2grTItGtDD5R1LYZZnCjA2rOVxLIph

Tues., Oct. 25: Young Institute for Advanced Manufacturing of Pharmaceuticals Lecture Series, 1:30 p.m., Wilmeth Active Learning Center (WALC) B066. Asif Ansari, Director, Technical Portfolio Lead-Vaccines, Pfizer will present “Supplying mRNA COVID-19 Vaccine at Unprecedented Pace and Scale.” Asif Ansari, Ph.D. has over 20 years of experience in the biopharmaceutical industry in leading multifunctional and global teams in developing product lifecycle strategies and providing technical and regulatory support for full-scale commercial and clinical biologics manufacturing. After 5 years with Bayer as a process engineer, he has held site and global positions of increasing responsibility with Pfizer since 2005. Ansari is currently the Technical Portfolio Lead-Vaccines in the Global Technology & Engineering group within Pfizer’s Global Supply organization where he also supported Pfizer’s COVID vaccine project. He is a proud graduate of Purdue’s Department of Chemical Engineering, receiving his B.S. in 1995, and he received his Ph.D. from Carnegie Mellon University in 2000.

Tues., Oct. 25: Mentoring Graduate Writers Workshop for faculty and postdocs: 2:00-3:30 p.m., A good deal of research indicates that mentoring graduate students on their writing is fraught with problems. This initial workshop will share a range of best practices around mentoring and writing in the disciplines, with the hope of making mentoring graduate writers more empowered, effective, and sustainable. Details below.

Tues., Oct. 25: Life Sciences Career Panel: Growing Opportunities for Scientists and Engineers, 4:00-4:45 p.m., Purdue Memorial Union, North Ballroom. The panel will consist of Asif Ansari, Director, Technical Portfolio Lead-Vaccines, Pfizer; Rae D. Record Ritchie, Senior Scientist, Cook Biotech; and Daniel Fricker, Site Head, Tippecanoe Laboratories.

Wed., Oct. 26: Weldon School of Biomedical Engineering Distinguished Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Junsuk Rho, Endowed Chair Professor and Young Distinguished Professor, Pohang University of Science and Technology (POSTECH), Korea and Visiting Professor at Northwestern University will present the Weldon School of BME's Distinguished Seminar on Wednesday, October 26, at 9:30 a.m. in MJIS 1001 and via Zoom. The presentation is entitled "Metamaterials: From invisibility cloak to future extended reality displays.”

Wed., Oct. 26: Graduate Mentorship Seminar Series: Building Healthy Mentorship Relationships. 4:30 p.m., WALC 2051. Hear from various COE faculty members and students in a panel-led discussion on how to develop good faculty mentor-student advising relationships. Faculty members welcome!

Wed., Oct. 26: Frontiers in Biophysics Seminar, 1:30 p.m., MJIS 1001 and via Zoom. Chun-liang Chen, Purdue University will present “Structural and mechanistic basis for Gβγ-mediated activation of phosphoinositide 3-kinaseγ. Co-sponsored by Structural and Computational Biology & Biophysics (SCBB) in the Department of Biological Sciences and the NIGMS-funded Molecular Biophysics Training Program (MBTP, in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology; and the following institutes: PI4D, PCCR, and PIDD. Register in advance for Zoom presentation at: https://purdue.edu/zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDGj76V5

Thurs., Oct. 27: Seminar in Hearing Research, 10:30 a.m., LYLE 1150 and via Zoom. Matt Hay will present "A Personal Journey with Neurofibromatosis Type 2 (NF2) and Auditory Brainstem Implantation (ABI).” Bio: Matt Hay, author, keynote speaker, patient advocate, university guest lecturer, and auditory brainstem implant (ABI) user. lives with neurofibromatosis type 2 (NF2). He currently resides in Westfield, Indiana with his wife and children, where he works as a Consumer Insights Analyst. He is also a member of the Board of Directors of the Children’s Tumor Foundation and is the U.S. Director of Advocacy for Neurofibromatosis. Zoom link: https://purdue-edu.zoom.uslj/4326340458 Meeting ID: 432 634 0458

Thurs., Oct. 27: BMS 692/CPB 697 Graduate Seminar, 3:30 p.m., LYNN 1136. Four graduate research assistants will present their current research. Marwa Alhashimi - Graduate RA, CPB - will present "Next Generation of Adenoviral Vector Vaccines to Combat COVID-19." Kristine Towns - Resident, CPB - will present "Laboratory Animal Medicine: It's More Than Just a Mouse!" Vishnu Manikantan - Graduate RA, CPB - will present "In-Vitro Characterization of the Effect of Ivermectin on Parascaris spp. Larvae-Derived Extracellular Vesicles." Abhishek Datta - Graduate RA, CPB - will present "Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida Albicans in the Intestine." The seminars are hosted by the College of Veterinary Medicine.

Fri., Oct. 28: Purdue Quantum Science and Engineering Institute Seminar, 10:00 a.m., BRK 2001 and via Zoom. Dr. Vladislav V. Yakovlev, Texas A&M University will present “Seeing life in a new light: From simple classical physics to quantum-enhanced imaging.”

Upcoming important deadlines and info.

Tues., Nov. 1: Special BME Seminar: 11:00-12:00 p.m., MJIS 2001. Pierre Sicard, PhD, Research Engineer at Universite de Montpellier, INSERM, France will present “Cerebrovascular Hypoxia During Experimental Traumatic Brain Injury.”

Tues., Nov. 1: Proposals due for WL-Indy Collaborative Seed Grant. (From Jay Akridge): “We are happy to announce a collaborative seed grant competition, which is focused on establishing new research collaborations between faculty located at our two campuses. Please review the attached guidelines and reach out to colleagues to start building new research collaborations. Proposals are due November 1, 2022. See attached RFP.

Tues., Nov. 1: Mentoring and the Dissertation Process for faculty and postdocs, 2:00-3:30 p.m. . You must have a GoSignMeUp account to register for this free workshop. See details below.

Wed., Nov. 2: COE “Celebrating our Associate Professors” Session, 11:30 a.m. This event features recently tenured associate professors making a 10-minute presentation on some aspect of their teaching/learning, research and/or engagement activities, followed by an opportunity to discuss the presented work with other colleagues in attendance. IE/BME’s very own Ramses Martinez will be one of the presenters on this date. Go to https://purdue.ca1.qualtrics.com/jfe/form/SV_4GXBqUDu1DZdTn0 to register. After registering, you will receive a confirmation email containing information about joining the meeting.

Wed., Nov. 2: Frontiers in Biophysics Seminar, 1:30 p.m., via Zoom. Thomas Wollert, Institut Pasteur Paris will present “Formation of autophagosomes by a concerted action of ATG16L1 and LC3B.” Co-sponsored by Structural and Computational Biology & Biophysics (SCBB) in the Department of Biological Sciences and the NIGMS-funded Molecular Biophysics Training Program (MBTP, in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology; and the following institutes: PI4D, PCCR, and PIDD. Register in advance for Zoom presentation at: https://purdue.edu/zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDGj76V5

Wed., Nov. 2: Seminar for Neurotrauma and Diseases, 4:00 p.m. via Zoom. Philip Low, Presidential Scholar for Drug Discovery and Ralph C. Corley Distinguished Professor of Chemistry at Purdue University will present “Targeted therapies for inflammatory, malignant and infectious diseases.” The Seminar for Neurotrauma and Diseases is sponsored by Plexon, a leading neuroscience technology company, and is supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Join the Center for Paralysis Research and our set of amazing speakers as we explore various facets of neurotrauma and diseases and build a community to make long-lasting impacts on neurotrauma research. Zoom link: https://bit.ly/3QN4YL.

Thurs., Nov. 3: Travel Workshop will be held in the 1^st floor computer lab on Thursday, November 3 from 1:00-3:00 p.m. Please plan to attend if you would like assistance with creating or submitting an expense report in Concur. Please email Pam Lamb lambp@purdue.edu if you will be attending.

Wed., Nov. 9: Frontiers in Biophysics Seminar, 1:30 p.m., MJIS 1001 and via Zoom. Andrei Fokine, Purdue University will present “Structure and assembly of Myoviridae bacteriophages.” Co-sponsored by Structural and Computational Biology & Biophysics (SCBB) in the Department of Biological Sciences and the NIGMS-funded Molecular Biophysics Training Program (MBTP, in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology; and the following institutes: PI4D, PCCR, and PIDD. Register in advance for Zoom presentation at: https://purdue.edu/zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDGj76V5

Wed., Nov. 9: Seminar for Neurotrauma and Diseases, 4:00 p.m. via Zoom. Wen Jiang, Professor of Biological Sciences and Scientific Director of Purdue Cryo-EM Facility will present “Cryo-EM structural characterization of amyloid fibrils in neurodegenerative diseases.” The Seminar for Neurotrauma and Diseases is sponsored by Plexon, a leading neuroscience technology company, and is supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Join the Center for Paralysis Research and our set of amazing speakers as we explore various facets of neurotrauma and diseases and build a community to make long-lasting impacts on neurotrauma research. Zoom link: https://bit.ly/3QN4YL.

Wed., Nov. 9: Graduate Mentorship Seminar Series: Diversity and Inclusion in Mentorship Relationships, 4:30 p.m., WALC 2051. Learn about how identity and culture are crucial components to recognize in faculty mentor-student advising relationships. Faculty members welcome!

Wed., Nov. 9 – Sat., Nov. 12: The Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) is a go-to conference for underrepresented groups in STEM fields. Scientific or professional development session submissions due July 29.

Thurs., Nov. 10: BME Faculty Coffee Chats for Grad Students, 9:30-10:30 a.m., MJIS 3041. Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl. Potential discussion topics: ask me anything/ healthcare, academic jobs/academia, visas/international students

Thurs., Dec. 8: BME Faculty Coffee Chats for Grad Students, 2:00-3:00 p.m., MJIS 2041. Faculty host: Deva Chan. Potential discussion topics: AMA work-life, teaching & diversity statements, time management

Thurs., Dec. 15 The BME Senior Design Expo will be from 3:30 - 5:30pm in MJIS. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details.

PROTECT PURDUE

Fall 2022 update: Protect Purdue Fall expectations

https://protect.purdue.edu/updates/fall-2022-what-you-need-to-know/

Committee Updates

Business Services Update

Thurs., Nov. 3: Travel Workshop will be held in the 1^st floor computer lab on Thursday, November 3 from 1:00-3:00 p.m. Please plan to attend if you would like assistance with creating or submitting an expense report in Concur. Please email Pam Lamb lambp@purdue.edu if you will be attending.

Undergraduate Programs Update

The BME Senior Design Expo will be Thursday, December 15 from 3:30 - 5:30pm in MJIS. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details.

Graduate Office Update

COE Graduate Mentor Seminar Series

In case you missed the excellent workshop this week on “Navigating Toxic Environments” with Dr. Gonzalez-Perez (Associate Dean for Diversity Initiatives) from Princeton, a recording is available (view that here). This virtual seminar covered how to better identify attributes that can lead to poor mentorship relationships or environments and mitigating tips.

The next seminar in this series is on Wednesday, October 26th from 4:30-5:30pm in WALC 2051! Contact Stephen McBride (Assistant Director, Graduate Student Success; College of Engineering - Graduate Education) for more information on this seminar series, or anything else related to the College’s work/initiatives to support graduate students https://engineering.purdue.edu/Engr/Academics/Graduate.

BME Coffee Chats

We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊.

These coffee chats will attempt to accomplish some priorities that have been shared with us by you:

First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee.
Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics.
Increase faculty involvement with graduate students outside of their own lab.
Help build community between grad students.

Here are the dates and faculty for fall:

November

Date: November 10^th

Time: 9:30 am-10:30 am

Location: MJIS 3041

Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl

Potential discussion topics: ask me anything/healthcare, academic jobs/academia, visas/international students

December:

Date: December 8th

Time: 2:00 pm-3:00 pm

Location: MJIS 2041

Faculty host: Deva Chan

Potential discussion topics: AMA work-life, teaching & diversity statements, time management

Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included.

Graduate Admissions Update

Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions

DateDATE	Activity
Now	Research Areas create a plan and potentially agree on dates to meet ranking deadlines. December 19th—All Fellowship Nominations Due
Oct. 26	Deadline to sign up for a speaker slot during Nov 10th Virtual Event
Oct 27	Send invitation to all applicants for Virtual Recruiting Faculty Research Presentations
Nov 10	Virtual Recruiting Faculty Research Presentations (3-5:30 pm presentations)
Dec 1	Complete applications due for priority admission and funding consideration
Dec 2	Prescreening of eligibility of Purdue Doctoral and George Washington Carver sent to faculty
Dec 2	Spreadsheet and applications posted to Engineering Intranet for Research Area and faculty review
Dec 19	DUE: All Fellowship Nominations and Additional Invite Lists
Dec 20	Grad office to process admission for all fellowship-nominated applicants to the Purdue Graduate School and any additional applicants you would like to admit from the open house invitation list.
Dec 20	Tammy to send invitations to invited students to participate in our virtual open house.
Jan 3	Deadline for students to respond to Open House RSVP (hotels released today).
Jan 26	Agendas for all invited students due from faculty to Tammy and sent to student.
Feb 2-4	Weldon School Visitation Days (Hybrid)
Feb 8	Last chance for Research Areas / Faculty to remove students from fellowship consideration
Feb 10	Fellowship offers announced and complete rankings list made available to BME faculty; BME Graduate Office will notify students by email (offer letters distributed as soon as signed by BME Head and COE Dean)
Mar 10	DUE: All Master’s students to be decisioned as either admit, deny or hold
Mar 31	Due: All PhD students to be decisioned as either admit, deny or hold
April 15	Graduate applicant acceptance deadline

Research Area Update

The NIH OITE is pleased to offer the RAISING A RESILIENT SCIENTIST series for faculty, staff scientists, and administrators who mentor students and postdoctoral fellows in the biomedical, behavioral, and social sciences. A variety of topics will be covered with a specific focus on communication and shared problem-solving to help trainees deal with the inevitable setbacks experienced in high knowledge environments. The goal of the Raising a Resilient Scientist series is to promote the mental health and well-being of the academic research community by supporting faculty and administrators to develop self-management, relationship-management, and mentoring skills. There will be five units in the series and start on November 9^th, 2022; each unit will consist of a 75-minute lecture followed by a 1-hour facilitated discussion with peers.

Previous participants found participation very valuable, and the tools presented practical and actionable. Here is what those who participated in series have to say:

“Informative workshop that I think all faculty should be required to attend. Making this a requirement for mentoring teams for fellowship and training grants would be a great approach! They need to be invested in mentoring and training, as much as training fellows.”
“Thank you! I've done a lot of mentoring workshops/training but feel like this one is already taking things to another level.”
“This course needs to be offered again and again, such an important resource in any academic curriculum.”

There is no charge for participation, but advanced registration is required. For more information, and to register, please visit our webpage. Participation in the entire series is recommended but is not required. Please do not hesitate to email us if you have any questions.

Dr. Sharon L. Milgram

(she/her/hers)

Director, NIH Office of Intramural Training & Education

NIH Office of the Director

www.training.nih.gov

Resources, attachments, further information

Purdue Center for Cancer Research Monthly Series on Career Development: A Panel Discussion with Assistant Professors in Cancer Research: Graduate School, Postdoc and Beyond, Tues., Oct. 25, 12:00-1:00 p.m. via Zoom. Register at: https://purdue-edu.zoom.us/meeting/register/tJYode2grTItGtDD5R1LYZZnCjA2rOVxLIph

Questions that you could ask the panelists:

How did you find your postdoc?
What are the secrets for a successful postdoctoral training?
How to find mentors?
How to make yourself stand out as an academic faculty candidate?
Bring your own set of questions!

Panelists:

Lauren Ann Metskas, Ph.D. Assistant Professor, Department of Biological Sciences

Matthew Scarpelli, Ph.D. Assistant Professor, School of Health Sciences

Chi Zhang, Ph.D. Assistant Professor, Department of Chemistry

Check out other PCCR career development events and resources at: https://www.purdue.edu/cancer-research/training-and-education/Monthly%20Series%20on%20Career%20Development.php

Questions: yang1491@purdue.edu

Mentoring Graduate Writers Workshop for faculty and postdocs: Tues., Oct. 25, 2:00-3:30 p.m., A good deal of research indicates that mentoring graduate students on their writing is fraught with problems. This initial workshop will share a range of best practices around mentoring and writing in the disciplines, with the hope of making mentoring graduate writers more empowered, effective, and sustainable. Participants will learn strategies for sound response and receive materials to take away and study. Depending on faculty interest, additional workshops will be scheduled to address needs that arise during the conversation. This workshop is for faculty and postdocs only. Register: https://gspd.gosignmeup.com/public/Course/browse?courseid=3923

Weldon School of Biomedical Engineering Distinguished Seminar Series, Wed., Oct. 26, 9:30 a.m., MJIS 1001 or via Zoom. Junsuk Rho, Endowed Chair Professor and Young Distinguished Professor, Pohang University of Science and Technology (POSTECH), Korea and Visiting Professor at Northwestern University will present the Weldon School of BME's Distinguished Seminar on Wednesday, October 26, at 9:30 a.m. in MJIS 1001 and via Zoom. The presentation is entitled "Metamaterials: From invisibility cloak to future extended reality displays.”

Abstract: The invisibility cloak in Harry Potter and the dreams of invisibility as a superpower are no longer fiction. With the invention of metamaterials, they are theoretically and experimentally possible in real life. Metamaterials — materials that are engineered to have properties that are not found in naturally-occurring materials — allow us to overcome physical and biological limitations. Scientists around the world are researching metamaterials that can be used in diverse sectors, including healthcare, optical display, and military affairs. For example, metalenses, which can exceed the physical limitations of light, may facilitate leaps in biological, biomedical, and medical applications. The development of metamaterials has just begun, but their potential is limitless. In this talk, I will give a brief overview of metamaterials and metasurfaces: principles, applications and manufacturing methods towards their science-to-technology transition.

Bio: Prof. Rho is a Mu-Eun-Jae Endowed Chair Professor and Young Distinguished Professor at Pohang University of Science and Technology (POSTECH), Korea, with a double appointment in the Department of Chemical Engineering and the Department of Mechanical Engineering. He received his Ph.D. at the University of California, Berkeley (2013), M.S. at the University of Illinois, Urbana-Champaign (2008) and B.S. at Seoul National University, Korea (2007) all in Mechanical Engineering. Prior joining POSTECH, he conducted postdoctoral research in Materials Sciences Division & Molecular Foundry at Lawrence Berkeley National Laboratory, and also worked as a principal investigator (Ugo Fano Fellow) in Nanoscience and Technology Division & the Center for Nanoscale Materials at Argonne National Laboratory. Prof. Rho has authored and co-authored more than 250 high-impact journal papers including Science, Nature, Nature Nanotechnology, Nature Materials, Nature Photonics and Chemical Reviews. He serves 13 editorial positions including Light: Science and Applications (Springer-Nature), Microsystems and Nanoengineering (Springer-Nature) and Nanophotonics (De Gruyter).

~BME Faculty Host: Dr. Young Kim ~

Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09

NOTE: Students registered for the seminar are expected to attend in-person.

Purdue Quantum Science and Engineering Institute Seminar, Fri., Oct. 28, 10:00 a.m., BRK 2001 and via Zoom. Dr. Vladislav V. Yakovlev, Texas A&M University will present “Seeing life in a new light: From simple classical physics to quantum-enhanced imaging.”

Abstract: The progress of biomedical sciences depends on the availability of advanced instrumentation and imaging tools capable of attaining the state of biological systems in vivo without using exogenous markers. Mechanical forces and local elasticity play a central role in understanding physical interactions in all living systems. We demonstrate a novel way to image microscopic viscoelastic properties of biological systems using Brillouin microspectroscopy [1]. In my talk, I will discuss the ways how an old spectroscopic tool can be used for real time microscopic imaging [2-3] and provide possible solutions to long standing problems in Life Sciences and Medicine [4-6] while advancing instrumentation beyond classical limits [7].

References:

[1] Zh. Meng, A. Traverso, C. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Advances in Optics and Photonics 8(2), 300-327 (2016).

[2] Zh. Meng, S. C. Bustamante-Lopez, K. E. Meissner and V. V. Yakovlev, “Subcellular imaging of mechanical and chemical properties using Brillouin microspectroscopy,” Journal of Biophotonics 9(3), 201-207 (2016).

[3] C. W. Ballmann, Zh. Meng, A. J. Traverso, M. O. Scully, and V. V. Yakovlev “Impulsive Brillouin microscopy,” Optica 4(1), 124-128 (2017).

[4] Zh. Meng, T. Thakur, C. Chitrakar, M. K. Jaiswal, A. K. Gaharwar, and V. V. Yakovlev, “Assessment of local heterogeneity in mechanical properties of a bulk hydrogel network,” ACS Nano 11(8), 7690–7696 (2017).

[5] M. Troyanova-Wood, Zh. Meng, and V. V. Yakovlev, “Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy,” Biomedical Optics Express 10(4), 1774-1781 (2019).

[6] D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, Zh. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” Journal of Biomedical Optics 23(9), 097004 (2018).

[7] T Li, F Li, X Liu, VV Yakovlev, GS Agarwal, “Quantum-enhanced stimulated Brillouin scattering spectroscopy and imaging,” Optica 9(8), 959-964 (2022)

Host: Prof. Alexandra Boltasseva

Virtual Option: Zoom Link

This seminar is sponsored by the Purdue Quantum Science and Engineering Institute’s Emerging Frontiers Center Crossroads of Quantum and AI.

Special BME Seminar, Tues., Nov. 1, 11:00-12:00 p.m., MJIS 2001. Pierre Sicard, PhD, Research Engineer at Universite de Montpellier, INSERM, France will present “Cerebrovascular Hypoxia During Experimental Traumatic Brain Injury.”

Abstract

Background: Retrospective studies suggest that mild traumatic brain injury (mTBI) in pediatric patients may lead to an increased risk of cardiac events. However, the exact functional and temporal dynamics and the associations between heart-brain pathophysiological trajectories are not understood.

Methods: A single impact to the left somatosensory cortical area of the intact cranium was performed on juvenile mice 17 days postnatal. Cerebral 3D photoacoustic imaging was used to measure the oxygen saturation (sO₂) in the impacted area 4 hours after mTBI followed by 2D and 4D echocardiography at days 7, 30, 90, and 190 post-impact. At 8 months, we performed a dobutamine stress test to evaluate cardiac function. Lastly, behavioral analyses were conducted one year after initial injury.

Results: We report a rapid and transient decrease in cerebrovascular sO₂ and increased hemoglobin in the impacted left cortex. Cardiac analyses showed long-term diastolic dysfunction and a diminished systolic strain response under stress. We found linear correlations between brain oxygenation immediately post-mTBI and long-term cardiac strain after 8 months (r = -0.55, p = 0.03). We also found that initial cerebrovascular hypoxia chronic cardiac systolic dysfunction correlated with long-term behavioral changes, namely decreased time spent in the center of an open field and novel object recognition, hinting to anxiety-like and memory maladaptation.

Conclusion: Experimental juvenile mTBI induces time-dependent cardiac dysfunction that corresponds to the initial cerebrovascular sO₂ dip and is associated with long-term behavior. These biomarkers of the heart-brain axis could be applied to improve clinical pediatric mTBI treatment.

Biography

Dr. Pierre Sicard is a research engineer at INSERM in Montpellier (France) where he leads the ultrasound/photoacoustic platform on campus (IPAM/INSERM/ Montpellier University). Dr Sicard obtained in 2007, from the University of Burgundy, a PhD in Cardiovascular Physiology. He studied the interplay between oxidative stress, hypertension and their consequences on the heart. In 2007, he joined the cardiovascular division at St Thomas’ Hospital (King’s College London, UK) as a postdoctoral fellow to investigate the importance of p38 MAPK isoforms during experimental myocardial infarction. He continued his research in the Institute of Metabolic and Cardiovascular Diseases in Toulouse (France) in order to develop a bench to bedside project about the potential contribution of Gadd45 proteins in post-myocardial infarction remodeling. His current research interests focused on the mechanism involved in multiple-organ dysfunction after traumatic injury.

~BME Faculty Host: Craig Goergen~

Mentoring and the Dissertation Process for faculty and postdocs, Tues., Nov. 1, 2:00-3:30 p.m. Among the most consequential documents that writers produce in graduate school is the dissertation. Strong mentoring at specific critical junctures in the dissertation process can strengthen both the document itself and graduate students’ abilities to later support their own graduate students. Unfortunately, most faculty receive little to no training about the writing instruction central to the dissertation process, from invention to final deposit. Instead, they rely upon their own experiences producing a doctoral thesis, which might have been problematic and trauma producing or wonderful yet still mystifying. This workshop incorporates current research on graduate student writing and builds on insights about graduate student struggles that the Writing Lab gains through working with dissertation writers. Faculty will be offered actionable strategies for helping dissertation writers be more effective. The workshop also will offer faculty mentors guidance on when and how to direct their students to the Writing Lab for intensive and on-going support. This workshop is for faculty and postdocs only. You must have a GoSignMeUp account to register for this free workshop. Registration: https://gspd.gosignmeup.com/public/Course/browse?courseid=3923