BME
MONDAY ROUNDTABLE
May
1, 2023
(FINALS
WEEK)
DEPUTY
HEAD’S NOTE
May
has finally come, which means we are so close to the end of the semester. I just want to wish you a successful end of the semester here!
- As
you know, Purdue had its annual Day of Giving. In total, the event raised more than $110M. I believe it was the first time a leaderboard was set up to track the amount of money raised by each academic unit. I am so proud that we came in as no. 18 with a total
of more than $644K raised in one day. Among the engineering departments, we only trailed the big boys, ECE, ChE, ME, Civil Eng, AAE. I hope we can set a higher target and be strategic and proactive about it for next year. Every penny counts and every penny
will come back to supporting our learning, research, and engagement.
- We
had a wonderful End-of-Year Celebration last Friday, organized by jointly by Purdue BMES and BMEGSA. Thanks to those who put up this event in a short amount of time. Several Undergraduate Scholarships, Graduate Awards, and TA Awards were presented. Congratulations
to the graduate students who won the awards. Thanks to the faculty, staff, and graduate students, who worked closely with the undergraduate award recipients. Most importantly, past Friday’s event was regarded a de-stress event for students as they were about
to enter the Final Exams week.
- I
personally encourage you to participate in the Weldon School Climate Survey. It is a survey focusing on the issues of diversity, equity, and inclusion. This survey will take about 10 – 15 minutes to complete. Your input is highly valued. We will be able to
use the information to guide our DEI efforts over the next year in order to improve the culture of the school. As you know, our school has been a frontrunner on DEI efforts at the college and the university. We want to keep our momentum. Many thanks to Professors
Luis Solorio and Elsje Pienaar. If you have questions, please contact them.
- Qualifying
exams are still under way. Many of the faculty have served with the best of their capacity in these exams. My great appreciation to you especially in this time of the semester. We will continue to collect data and monitor the process. We have expected the
adoption of qualifying examination of this form would enhance our PhD students for their preparation in the pursuit of research and professional development. First-year graduate students, I encourage you to reach out to me, Dr. Tami Kinzer-Ursem, and Dr. Mike
Heinz if you have questions and comments. The faculty panelists, please do so as well.
- We
will have our BME faculty/staff Happy Hour on May 17th to celebrate the end of the semester and more importantly, welcome the two new members of the Weldon School. Please come out to have an epic pre-summer celebration.
Important
MJIS Alert
Starting
Tuesday, May 16th (NOTE new date!), Martin Jischke Drive will be CLOSED to all traffic.
The
university will be performing
infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process
yet. Stay tuned for additional details.
UPCOMING
IMPORTANT DATES
Week
of April 24
Mon.,
May 1 – Fri., May 5: Final Exams Week.
Tues.,
May 2: BME
PhD Preliminary Exam Announcement for Awadh M. Alhawwash
(K. Yoshida and H. Lee, co-advisors). Everyone is invited to attend the public presentation beginning at 1:00 PM in
IUPUI SL 220A or via Zoom. Title: Exploring Sinusoidal Low Frequency Alternating Currents (LFAC) as a New Modality for Functional Electrical Stimulation.
Tues.,
May 2: Elmore
Family School of Electrical & Computer Engineering Distinguished Seminar,
10:30 a.m.-11:45 a.m., WALC 2088 and via Zoom. Stephen A. Boppart, MD, PhD, Professor and Grainger Distinguished Chair in Engineering, University of Illinois, Urbana-Champaign will present “Imaging with Artificial Intelligence for Identifying Optical Biosignatures
of Disease using Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) Microscopy.”
Upcoming
important deadlines and info.
Mon.,
May 8: BME
PhD Preliminary Exam Announcement for Brendan K. Ball
(D. Brubaker, advisor), 11:00 a.m., MJIS 2001 and via Zoom. Title:
Alzheimer’s Disease Pathology Driven by Orexin and Type 2 Diabetes.
Wed.,
May 10: BME
PhD Defense Announcement for James K. Nolan
(H. Lee, advisor), 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors.
Wed.,
May 10: BME
PhD Preliminary Exam Announcement for Michael Zimmerman
(A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations.
Fri.,
May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial,
sponsored
by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN.
Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up
of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward
with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program
Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial
Fri.,
May 12: Diabetes
Data and Hypothesis Hub (D2H2) Seminar,
12:00
p.m., via Zoom. Dr.
Avi Ma’ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration.”
Register
here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg
Wed.,
May 17: BME Summer Seminar Series, 9:30
a.m., via Zoom. The BME Summer Seminar Series will run from May 17th – August 9th. The first week’s speakers will be Ruhi Sharmin and Brendan Ball. Full schedule is attached.
Thurs.,
May 25:
Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars
for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential
impact in expanding representation and diversity in engineering. See attached flyer for application instructions.
Committee
Updates
Academic
Programs Update
Fall
2023 Course Schedule
is
attached to this email.
Full
Term (16 Weeks) and Second Eight-Week Session grade entry (meeting between March 6 and May 6) begins at 8 a.m. April 21 and ends promptly at 5 p.m. May 9.
-
Now
is the perfect time for faculty to take the 15 minutes to get all their required
certifications up to date BEFORE the deadline approaches.
- FERPA
- GLBA
- Data
Handling
-
Protecting
SSNs
- This
page
provides myPurdue grade entry instructions.
- This
page
provides BrightSpace final grade submission instructions.
- Those
not making the deadline can use the Grade Change Workflow.
- Instructions
may be found here.
- Lastly
but still very important, any faculty that assigned an Incomplete in Spring 2022
has until Tuesday, May 2 at 5pm to use the Grade Change Workflow to submit a completion grade. If not submitted by this deadline it will revert to an IF grade for the student.
- Any
extension requests for students that faced obstacles outside of their control should be submitted to
@Shomaker,
Lori
no later than Friday, May 5 for processing.
Graduate
Office Update
Dear
BME Faculty,
Weldon
BME PhD students performing research in one of these areas - cardiovascular devices, implantable biomaterials design, drug-delivery systems, or biochemical sensors – are eligible for nomination for the Ronald W. Dollens Scholarship.
For
the nomination, we will need from you a short description (less than 250 words) of an outstanding, current graduate student in your lab who is excelling in research performance and service to the department. In your description, please mention/include the
following:
- Student’s
year in the PhD program (1st year, 2nd year, etc.)
- Brief
description of outstanding research performance
- Brief
description of service to the department
- Mention
of recent awards, presentations made at conferences, papers authored, etc., that you think help describe the student’s contributions
- Student’s
CV
Please
send the nomination to tsiemers@purdue.edu
by Sunday, May 21st.
The
Ronald W. Dollens Scholarships in Life Sciences will be awarded based on academic merit to two deserving graduate students in the Weldon School of Biomedical Engineering who meet the criteria and are selected. The
scholarship award is $5,000 with half being awarded in the Fall 2023 semester and half in the Spring 2024 semester.
If
you have any questions, please don’t hesitate to reach out.
New
Course for Fall 2023:
BME 69500 Pediatric Medical Devices (CRN 14011). Details below.
Research
Update
To
safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and “hidden” predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned.
Participants
needed for a Motor Function Study,
“Development of a Diagnostic System for Assessment of Motor Impairment,” IRB# IRB-2022-1299. See below for details.
Resources
and further information
BME
PhD Preliminary Exam Announcement for Awadh M. Alhawwash,
(K. Yoshida and H. Lee, co-advisors). Everyone is invited to attend the public presentation on
Tues.,
May 2,
beginning at 1:00 PM in IUPUI SL 220A or via Zoom.
Title: Exploring Sinusoidal Low Frequency Alternating Currents (LFAC) as a New Modality for Functional Electrical Stimulation.
Committee
members: Dr. Ken Yoshida (Co-advisor),
Dr. Hyowon Hugh Lee (Co-advisor),
Dr. Edward J. Berbari, Dr. Matthew P. Ward
Abstract:
Functional Electrical Stimulation (FES) is a promising rehabilitative technology that provides hope for restoring functional movements in patients suffering from paralysis caused by spinal cord injury, stroke, or traumatic brain injury. However, the clinical
effectiveness of FES is limited by the simultaneous occurrence of muscle fatigue and excessive metabolic cost resulting from the reversed order of muscle fiber recruitment of conventional pulse stimulation. In this project, we propose the use of sinusoidal
low frequency alternating current (LFAC) stimulation as a novel motor nerve stimulation method. Our pilot study in a rabbit model showed that LFAC stimulation induced long-lasting non-fatiguing muscle contractions, necessitating further investigation. This
research aims to explore and comprehensively analyze the muscle contractions elicited by LFAC stimulation using cuff electrodes. Electrodes are placed on the sciatic nerve of anesthetized rats to evoke motor activity using pulse and LFAC stimulation. The order
of motor unit recruitment and rate of muscle fatigue are compared for LFAC and pulse stimulation. The initial results indicate that the muscle is activated by LFAC stimulation. The EMG activity was phase-locked to the sinusoidal cycle but exhibited two distinct
phenotypes: burst and unitary. The LFAC activation threshold was frequency-dependent and influenced by the cuff electrode geometry. The soleus muscle, mediated by smaller caliber alpha motor neurons, generally had a lower LFAC activation threshold than the
lateral gastrocnemius, mediated by larger caliber alpha motor neurons. This finding suggests a normal "physiological" recruitment order is obtained using LFAC stimulation. A comparison of fatigue rate between pulse and LFAC stimulation is pending, but initial
indications are that LFAC-based stimulation has greater fatigue resistance but greater force production variability. Systematic characterization of LFAC-based motor nerve stimulation aims to provide empirical evidence to identify the mechanism and locus of
action of LFAC stimulation. This will establish a foundation for LFAC to be developed as a new modality in the field of neuromodulation, with the potential to overcome limitations and enhance the effectiveness and usability of FES technology.
Zoom
link: https://purdue-edu.zoom.us/j/91256810994?pwd=ai9qR3EvWndIRW9paEx3eE4yM2RjZz09
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Elmore
Family School of Electrical & Computer Engineering Distinguished Seminar,
Tues., May 2, 10:30 a.m.-11:45 a.m., WALC 2088 and via Zoom. Stephen A. Boppart, MD, PhD, Professor and Grainger Distinguished Chair in Engineering, University of Illinois, Urbana-Champaign will present “Imaging with Artificial
Intelligence for Identifying Optical Biosignatures of Disease using Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) Microscopy.”
Abstract:
Label-free intravital optical imaging and imaging of fresh, unstained, resected tissue specimens, offers a wealth of new biosignatures for revealing the true colors of cancer and diagnosing neurodegenerative changes. Using new optical source technology
and nonlinear optics to generate new excitation wavelengths and manipulate the light stimulus in new ways, Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) microscopy can achieve fast simultaneous visualization of the rich intrinsic molecular
and metabolic features within tissues. Quantitative machine/deep learning analyses of these multi-dimensional datasets can be used to identify selective diagnostic biosignatures for disease. Specifically, extracellular vesicles (EVs) in carcinogenesis and
plaque composition in Alzheimer’s disease were analyzed via their optical signatures and spatial distributions. Analysis showed that EVs from the tumor microenvironment and variations in amyloid-beta plaques have unique optical signatures, in comparison to
those vesicles and tissues from healthy subjects. The clinical demonstration of these optical biomedical imaging technologies offers new paradigms for point-of-procedure diagnosis and guidance.
Bio:
Stephen Boppart is a Professor and Grainger Distinguished Chair in Engineering at the University of Illinois Urbana-Champaign (UIUC) with appointments in the Departments of Electrical and Computer Engineering, Bioengineering, the Carle Illinois College
of Medicine, and the Beckman Institute for Advanced Science and Technology. His Biophotonics Imaging Laboratory is focused on developing novel optical biomedical diagnostic and imaging technologies and translating these into clinical applications. Prof.
Boppart received his Ph.D. in Medical and Electrical Engineering from MIT, his M.D. from Harvard Medical School. Prof. Boppart has been a strong advocate for the integration of engineering, technology, and medicine to advance human health and our healthcare
systems. He played an active role in the initiation, visioning, launch, and growth of the new engineering-based Carle Illinois College of Medicine at the University of Illinois Urbana-Champaign, and served as Executive Associate Dean and Chief Diversity Officer.
Currently he is serving as the Interim Director for the university’s Interdisciplinary Health Sciences Institute, and as the Illinois Co-Chair of the Mayo Clinic & Illinois Alliance for Technology-Based Healthcare. He is also leading the Chancellor’s charge
to develop a new cross-campus model for research and education in technology-inspired health innovation.
Host:
Prof. Meng Cui
Zoom
link: https://purdue-edu.zoom.us/j/99256954527
BME
PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor),
Mon.,
May 8, 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer’s Disease Pathology Driven by Orexin and Type 2 Diabetes.
Committee
Members: Doug Brubaker, Ph.D. (Chair), Elizabeth Proctor, Ph.D., Deva Chan, Ph.D., Tamara Kinzer-Ursem, Ph.D., Brendan Lucey, M.D.
Abstract:
Alzheimer’s disease (AD) is the most common form of dementia and is often presented with aggregates of amyloid-â and intracellular tau
proteins in the brain, which leads to downstream progressive memory loss and cognitive impairment. Multiple risk factors for AD development include age, genetics, and other pre-existing diseases such as type 2 diabetes (T2D). While up to 81% of people with
AD may have T2D or impaired glucose levels, the biological mechanisms by which T2D exacerbates AD pathology are not well-understood. Previous studies shown that orexin, a neuropeptide responsible for appetite, arousal, and wakefulness, to be involved in AD
and T2D pathology, which may be a potential link between the two diseases. We propose that protein aggregation in the brain, and metabolic processes regulated by the orexin network and T2D exacerbates AD pathology. To test this idea, we will first identify
functional and biological associations of gene expressions via protein interaction networks and gene set enrichment analysis. Second, we will incorporate publicly available mouse, post-mortem human brain tissue, and human cell line transcriptomic data into
our computational model to characterize pathways by which proteinopathy, T2D and orexin are predictive of human neuropathological status. Finally, we will quantify neuroinflammatory cytokines and gene expression by performing multiplexing assays and RNA sequencing
of primary neuron samples after stimulation with disease-associated metabolites and orexin antagonist. Upon completion of this study, we will have improved our understanding on biological mechanisms in which orexin and T2D exacerbates AD pathology, which may
introduce avenues for disease-directed therapeutics.
Zoom
Link: https://purdue-edu.zoom.us/j/5554725555
BME
PhD Defense Announcement for James K. Nolan (H. Lee, advisor),
Wed.,
May 10, 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors.
Committee:
Hyowon Lee, Chair; Aaron B. Bowman; Chi Hwan Lee; Jacqueline Linnes
Abstract:
Electrochemical biosensor arrays been integrated into microfluidic cell culture platforms have measured metabolic markers, proteins, and nucleic acids. There is a gap for electrochemical biosensor lab on a chip for simultaneously monitoring multiple neurotransmitters,
such as glutamate and dopamine, while compatible with recombinant fluorescent neurotransmitter and epigenetic biosensors. A microfluidic neuronal cell-culture platform with these capabilities would be a valuable tool for quantifying phenotypes of PD-linked
epigenetic change resulting from environmental chemical exposure. To this end, we aim to develop arrays of enzymatic electrochemical sensors for multi-analyte biosensing. We have developed sensors using direct ink writing robotic printing and conventional
thin film processing that can simultaneously measure neurotransmitters (glutamate) and metabolic biomarkers (glucose and lactate) together simultaneously in cell culture media. We have also shown the biocompatibility of theses sensors for neuronal cell culture.
What remains to do is verify their stability during many weeks exposure to cell culture conditions and to demonstrate glutamate measurement from glutaminergic neurons in a microfluidic chip.
BME
PhD Preliminary Exam Announcement for Michael Zimmerman (A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation on
Wed.,
May 10, beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations.
Committee:
Dr. Alexander Chubykin (Primary advisor),
Dr. Krishna Jayant (Co-advisor).
Dr. Maria Dadarlat,
Dr. Edward Bartlett
Abstract:
Autism spectrum disorder (ASD) is an extremely prevalent group of neurodevelopmental disorders that affects 2% of the population worldwide. Many of the symptoms of ASD emerge as difficulties with social communication or other comorbidities
such as mood disorders and epilepsy. A hallmark of ASD is disruption of sensory processing and filtering that is associated with either hyper- or hyposensitivity which impacts social interaction, daily functioning, and learning and memory. Currently, the underlying
mechanism causing this disruption has yet to be understood. Fragile X Syndrome (FX) is the most common monogenetic form of ASD, accounting for approximately 5% of all cases, and is a prime model for investigating this disruption. This work takes advantage
of emerging novel technologies and paradigms to unravel an underlying mechanism behind learning and memory and its impairment in FX. I find that low frequency theta oscillations emerge following familiarity in both the primary
visual cortex (V1) and hippocampus, which is known to encode memory, yet are primarily formed in V1. Additionally, with an active learning behavior paradigm, these oscillations are modified between stimuli and consistently weaker in FX mice, suggesting they
encode more than just familiarity. Finally, I propose future work that will utilize optogenetic stimulation to further investigate the role of these oscillations, and potentially identify a future therapy for ASDs.
Overall, this work is investigating the role of theta oscillations across the brain to understand their function in memory formation and encoding while also testing a potential therapeutic treatment for learning disability.
Zoom
link: https://purdue-edu.zoom.us/j/91953591881
Diabetes
Data and Hypothesis Hub (D2H2) Seminar,
Fri.,
May 12, 12:00
p.m., via Zoom. Dr.
Avi Ma’ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration.”
Register
here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg
Abstract:
This seminar will discuss two new interactive bioinformatics software tools that integrate knowledge from many NIH funded and other key resources for hypothesis generation. The Diabetes Data and Hypothesis Hub (D2H2) is a platform that integrates tools and
datasets related to diabetes research into one integrative platform. The Playbook Partnership Workflow Builder (PPWB) is a system that enables novice users to created bioinformatics workflows by exploring a network of distributed but connect microservices.
These two new tools will be demonstrated through a variety of use cases with applications that prioritize personalized drugs and targets for kidney disease, diabetes, and pan-cancer.
Bio:
Dr. Ma’ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences, Director of the Mount Sinai Center for Bioinformatics, and a faculty member of the Department of Artificial Intelligence and Human Health
at the Icahn School of Medicine at Mount Sinai in New York City. The Ma'ayan Laboratory applies computational methods to study the complexity of regulatory networks in mammalian cells. His research team develops software systems to help experimental biologists
form novel hypotheses from high-throughput data with a focus on drug and target discovery through machine learning and other statistical methods.
Participants
Needed for Research Study:
(Aditya
Shanghavi is a graduate student in Biomedical Engineering at Purdue.)
I
am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases
who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain
or discomfort.
We
will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This
study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should
take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude.
This
study is conducted in accordance with IRB # IRB-2022-1299.
If
you have more questions regarding this study, please contact Aditya Shanghavi at
ashangha@purdue.edu.
New
Course for Fall 2023:
BME 69500 Pediatric Medical Devices
(CRN 14011).
Fall
2023, 3.0 credit hours
Wednesdays
11:30-2:20 in MJIS 1083 (in person attendance only)
Prerequisite:
BME Graduate Standing
Course
Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children
are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology
are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout.
Weekly
Course Topics:
August
23 Pediatrics Introduction
August
30 Neonatology Introduction
September
6 Pediatric Device Design and Development I
September
13 Pediatric Device Design and Development II
September
20 Pediatric Device Regulation
September
27 Pediatric Clinical Studies
October
4 Pediatric Cardiology
October
18 Pediatric Cardiovascular Surgery
October
25 Pediatric Nephrology
November
1 Pediatric Pulmonology
November
8 Pediatric Wound Healing
November
15 Pediatric Gastroenterology
November
29 Ethical Considerations in Pediatrics
December
6 Future Directions and Trends
Primary
Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu
Numerous
experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate.
Attachments
BME Course Descriptions
2023ClimateSurveyFlyer_Emailing.pdf
Course List Fall 2023
Summer Seminar Flyer 2023